Search results
- 1.0571528 - BFÚ 2024 RIV GB eng J - Journal Article
Malina, Jaroslav - Kostrhunová, Hana - Song, H. - Scott, P. - Brabec, Viktor
Asymmetric triplex metallohelices stabilise DNA G-quadruplexes in promoter oncogene sequences and efficiently reduce their expression in cancer cells.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 38, č. 1 (2023), č. článku 2198678. ISSN 1475-6366. E-ISSN 1475-6374
R&D Projects: GA ČR(CZ) GA21-27514S
Institutional support: RVO:68081707
Keywords : Metallohelices * G-quadruplexes * telomeres * expression of oncogenes * DNA synthesis
OECD category: Biochemistry and molecular biology
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://www.tandfonline.com/doi/full/10.1080/14756366.2023.2198678
Permanent Link: https://hdl.handle.net/11104/0345688 - 2.0553871 - ÚOCHB 2023 RIV GB eng J - Journal Article
Benýšek, Jakub - Buša, Michal - Rubešová, Petra - Fanfrlík, Jindřich - Lepšík, Martin - Brynda, Jiří - Matoušková, Zuzana - Bartz, U. - Horn, Martin - Gütschow, M. - Mareš, Michael
Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 37, č. 1 (2022), s. 515-526. ISSN 1475-6366. E-ISSN 1475-6374
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : Cathepsin K * protease inhibitor * cyanohydrazide warhead * azadipeptide nitrile * crystal structure
OECD category: Biochemistry and molecular biology
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.1080/14756366.2021.2024527
Permanent Link: http://hdl.handle.net/11104/0328551 - 3.0543824 - ÚMG 2022 RIV GB eng J - Journal Article
Oleksak, P. - Psotka, M. - Vančurová, Markéta - Sapega, Olena - Bieblová, Jana - Reiniš, Milan - Ryšánek, David - Mikyšková, Romana - Chalupová, K. - Malinak, D. - Svobodová, J. - Andrýs, R. - Řehulková, H. - Skopek, V. - Ngoc Lam, P. - Bártek, Jiří - Hodný, Zdeněk - Musílek, K.
Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 36, č. 1 (2021), s. 410-424. ISSN 1475-6366. E-ISSN 1475-6374
R&D Projects: GA ČR(CZ) GA18-14259S
Institutional support: RVO:68378050
Keywords : STAT3 signalling pathway * cancer * SH2 domain * inhibitor * structure-activity relationship
OECD category: Biochemistry and molecular biology
Impact factor: 5.756, year: 2021
Method of publishing: Open access
https://www.tandfonline.com/doi/full/10.1080/14756366.2020.1871336
Permanent Link: http://hdl.handle.net/11104/0320942 - 4.0542020 - ÚOCHB 2022 RIV GB eng J - Journal Article
Dostál, Jiří - Brynda, Jiří - Vaňková, Lucie - Zia, S. R. - Pichová, Iva - Heidingsfeld, Olga - Lepšík, Martin
Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 36, č. 1 (2021), s. 914-921. ISSN 1475-6366. E-ISSN 1475-6374
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963 ; RVO:86652036
Keywords : inhibitor * crystal structure * peptidomimetics * hydrogen bonds * noncovalent interactions
OECD category: Organic chemistry
Impact factor: 5.756, year: 2021
Method of publishing: Open access
https://doi.org/10.1080/14756366.2021.1906664
Permanent Link: http://hdl.handle.net/11104/0319514 - 5.0539170 - ÚMG 2021 RIV GB eng J - Journal Article
Kugler, Michael - Holub, J. - Brynda, Jiří - Pospíšilová, K. - El Anwar, S. - Bavol, D. - Havránek, M. - Král, Vlastimil - Fábry, Milan - Gruner, B. - Řezáčová, Pavlína
The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 35, č. 1 (2020), s. 1800-1810. ISSN 1475-6366. E-ISSN 1475-6374
Institutional support: RVO:68378050
Keywords : tumor hypoxia * medicinal chemistry * drug discovery * binding-sites * inhibition * boron * pharmacophores * opportunities * conjugation * metastasis * Carbonic anhydrase IX * carborane * enzyme inhibitors * structure-activity relationship
OECD category: Biochemistry and molecular biology
Impact factor: 5.051, year: 2020
Method of publishing: Open access
https://www.tandfonline.com/doi/full/10.1080/14756366.2020.1816996
Permanent Link: http://hdl.handle.net/11104/0316870 - 6.0537297 - BC 2021 RIV GB eng J - Journal Article
Corrigan, T.S. - Diaz, L.M.L. - Border, S.E. - Ratigan, S.C. - Kasper, K.Q. - Sojka, Daniel - Fajtova, P. - Caffrey, C.R. - Salvesen, G. S. - McElroy, C.A. - Hadad, C.M. - Ekici, O.D.
Design, synthesis, andin vitroevaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 35, č. 1 (2020), s. 1387-1402. ISSN 1475-6366. E-ISSN 1475-6374
R&D Projects: GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344
Keywords : asparaginyl endopeptidase * schistosoma-mansoni * michael acceptors * caspase family * key mediators * legumain * expression * potent * generation * epoxides * Proteasome inhibitor * caspase and legumain inhibitors * aza-peptide carbonyls * anticancer * antiparasitic
OECD category: Microbiology
Impact factor: 5.051, year: 2020
Method of publishing: Open access
https://www.tandfonline.com/doi/pdf/10.1080/14756366.2020.1781107?needAcces
Permanent Link: http://hdl.handle.net/11104/0315029 - 7.0532715 - ÚOCHB 2021 RIV GB eng J - Journal Article
Kugler, Michael - Holub, Josef - Brynda, Jiří - Pospíšilová, Klára - El Anwar, Suzan - Bavol, Dmytro - Havránek, M. - Král, V. - Fábry, M. - Grüner, Bohumír - Řezáčová, Pavlína
The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 35, č. 1 (2020), s. 1800-1810. ISSN 1475-6366. E-ISSN 1475-6374
R&D Projects: GA ČR(CZ) GA18-27648S; GA TA ČR(CZ) TE01020028; GA MŠMT(CZ) EF16_019/0000729
Grant - others:AV ČR(CZ) L200321851
Program: Program podpory perspektivníchlidských zdrojů - postdoktorandů
Institutional support: RVO:61388963 ; RVO:61388980
Keywords : carbonic anhydrase IX * carbone * enzyme inhibitors * sulfonamide * structure-activity relationship
OECD category: Biochemistry and molecular biology; Inorganic and nuclear chemistry (UACH-T)
Impact factor: 5.051, year: 2020
Method of publishing: Open access
https://doi.org/10.1080/14756366.2020.1816996
Permanent Link: http://hdl.handle.net/11104/0311123File Download Size Commentary Version Access The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer associated carbonic anhydrase IX.pdf 2 3.7 MB Publisher’s postprint open-access - 8.0524320 - BFÚ 2021 RIV GB eng J - Journal Article
Guillon, J. - Cohen, A. - Boudot, C. - Valle, A. - Milano, V. - Das, R.N. - Gudin, A. - Moreau, S. - Ronga, L. - Savrimoutou, S. - Demourgues, A. - Reviriego, E. - Rubio, S. - Ferriez, S. - Agnamey, P. - Pauc, C. - Moukha, S. - Dozolme, P. - Da Nascimento, S. - Laumaille, P. - Bouchut, A. - Azas, N. - Mergny, Jean-Louis - Mullie, C. - Sonnet, P. - Courtioux, B.
Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 35, č. 1 (2020), s. 432-459. ISSN 1475-6366. E-ISSN 1475-6374
R&D Projects: GA MŠMT EF15_003/0000477
Institutional support: RVO:68081707
Keywords : antimalarial activity * in-vivo * antileishmanial agents * biological evaluation
OECD category: Biochemistry and molecular biology
Impact factor: 5.051, year: 2020
Method of publishing: Open access
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Permanent Link: http://hdl.handle.net/11104/0308683 - 9.0462783 - ÚEB 2017 RIV GB eng J - Journal Article
Wrobel, T.M. - Kielbus, M. - Kaczor, A.A. - Kryštof, Vladimír - Karczmarzyk, Z. - Wysocki, W. - Fruzinski, A. - Król, S. - Grabarska, A. - Stepulak, A. - Matosiuk, D.
Discovery of nitroaryl urea derivatives with antiproliferative properties.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 31, č. 4 (2016), s. 608-618. ISSN 1475-6366. E-ISSN 1475-6374
R&D Projects: GA ČR(CZ) GA15-15264S
Institutional support: RVO:61389030
Keywords : Antiproliferative * cancer * CDK inhibitor
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 4.293, year: 2016
Permanent Link: http://hdl.handle.net/11104/0262170File Download Size Commentary Version Access 2016_Wrobel_JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY_608.pdf 0 993.2 KB Other open-access - 10.0458543 - ÚOCHB 2017 RIV GB eng J - Journal Article
Chukwujekwu, J. C. - Rengasamy, K.R.R. - de Kock, C. A. - Smith, P. J. - Poštová Slavětínská, Lenka - van Staden, J.
Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves of Buddleja saligna Willd.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 31, č. 1 (2016), s. 63-66. ISSN 1475-6366. E-ISSN 1475-6374
Institutional support: RVO:61388963
Keywords : alpha-glucosidase * antidiabetic * antiplasmodial * Buddleja saligna * terpenoids
Subject RIV: CC - Organic Chemistry
Impact factor: 4.293, year: 2016
Permanent Link: http://hdl.handle.net/11104/0258804