Search results
- 1.0579447 - ÚOCHB 2025 RIV GB eng J - Journal Article
Misehe, Mbilo - Šála, Michal - Matoušová, Marika - Hercík, Kamil - Kocek, Hugo - Chalupská, Dominika - Chaloupecká, Ema - Hájek, Miroslav - Bouřa, Evžen - Mertlíková-Kaiserová, Helena - Nencka, Radim
Design, synthesis and evaluation of novel thieno[2,3d]pyrimidine derivatives as potent and specific RIPK2 inhibitors.
Bioorganic and Medicinal Chemistry Letters. Roč. 97, January (2024), č. článku 129567. ISSN 0960-894X. E-ISSN 1464-3405
R&D Projects: GA MZd(CZ) NU20-05-00472; GA MŠMT(CZ) LX22NPO5103
Grant - others:AV ČR(CZ) StrategieAV21/25
Program: StrategieAV
Institutional support: RVO:61388963
Keywords : kinase inhibitor * thieno [2,3d] pyrimidine derivative * receptor-interacting protein kinase 2 * RIPK2 * NOD
OECD category: Medicinal chemistry
Impact factor: 2.7, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.bmcl.2023.129567
Permanent Link: https://hdl.handle.net/11104/0348249File Download Size Commentary Version Access 10.1016j.bmcl.2023.129567.pdf 1 1.6 MB Publisher’s postprint open-access - 2.0574898 - ÚOCHB 2024 RIV NL eng J - Journal Article
Misehe, Mbilo - Matoušová, Marika - Dvořáková, Alexandra - Hercík, Kamil - Škach, Kryštof - Chalupská, Dominika - Dejmek, Milan - Šála, Michal - Hájek, Miroslav - Bouřa, Evžen - Mertlíková-Kaiserová, Helena - Nencka, Radim
Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases.
European Journal of Medicinal Chemistry. Roč. 260, November (2023), č. článku 115717. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) LX22NPO5103; GA MZd(CZ) NU20-05-00472
Institutional support: RVO:61388963
Keywords : kinase inhibitor * quinazoline derivatives * RIPK2 * NOD * inflammation * RIPK3
OECD category: Medicinal chemistry
Impact factor: 6.7, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.ejmech.2023.115717
Permanent Link: https://hdl.handle.net/11104/0344824File Download Size Commentary Version Access 10.1016j.ejmech.2023.115717.pdf 0 4.4 MB Publisher’s postprint open-access - 3.0562658 - ÚOCHB 2023 RIV GB eng J - Journal Article
Misehe, Mbilo - Klíma, Martin - Matoušová, Marika - Chalupská, Dominika - Dejmek, Milan - Šála, Michal - Mertlíková-Kaiserová, Helena - Bouřa, Evžen - Nencka, Radim
Structure-based design and modular synthesis of novel PI4K class II inhibitors bearing a 4-aminoquinazoline scaffold.
Bioorganic and Medicinal Chemistry Letters. Roč. 76, November (2022), č. článku 129010. ISSN 0960-894X. E-ISSN 1464-3405
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA MZd(CZ) NU20-05-00472
Institutional support: RVO:61388963
Keywords : phosphatidylinositol 4-kinase class II * PI4K2A inhibitor * quinazoline derivative * SAR investigation * ATP-binding site
OECD category: Biochemistry and molecular biology
Impact factor: 2.7, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.bmcl.2022.129010
Permanent Link: https://hdl.handle.net/11104/0334914
Research data: PDB