Search results
- 1.0576080 - ÚOCHB 2024 RIV NL eng J - Journal Article
Zgarbová, Michala - Otava, Tomáš - Šilhán, Jan - Nencka, Radim - Weber, Jan - Bouřa, Evžen
Inhibitors of mpox VP39 2′-O methyltransferase efficiently inhibit the monkeypox virus.
Antiviral Research. Roč. 218, October (2023), č. článku 105714. ISSN 0166-3542. E-ISSN 1872-9096
R&D Projects: GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963
Keywords : structural basis
OECD category: Virology
Impact factor: 7.6, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.antiviral.2023.105714
Permanent Link: https://hdl.handle.net/11104/0345703File Download Size Commentary Version Access 10.1016j.antiviral.2023.105714.pdf 0 1.7 MB Publisher’s postprint open-access - 2.0574383 - ÚOCHB 2024 RIV NL eng J - Journal Article
Dejmek, Milan - Brázdová, Andrea - Otava, Tomáš - Pimková Polidarová, Markéta - Klíma, Martin - Smola, Miroslav - Vavřina, Zdeněk - Buděšínský, Miloš - Dračínský, Martin - Liboska, Radek - Bouřa, Evžen - Birkuš, Gabriel - Nencka, Radim
Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
European Journal of Medicinal Chemistry. Roč. 259, November (2023), č. článku 115685. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) LX22NPO5103; GA MZd(CZ) NU20-05-00472
Research Infrastructure: CCP II - 90126
Institutional support: RVO:61388963
Keywords : cyclic dinucleotides * STING * cancer * intratumoral administration * immunotherapy
OECD category: Medicinal chemistry
Impact factor: 6.7, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.ejmech.2023.115685
Permanent Link: https://hdl.handle.net/11104/0344716File Download Size Commentary Version Access 10.1016j.ejmech.2023.115685.pdf 0 5.2 MB Publisher’s postprint open-access
Research data: PDB - 3.0574244 - ÚOCHB 2024 RIV US eng J - Journal Article
Štefek, Milan - Chalupská, Dominika - Chalupský, Karel - Zgarbová, Michala - Dvořáková, Alexandra - Krafčíková, Petra - Li, A. S. M. - Šála, Michal - Dejmek, Milan - Otava, Tomáš - Chaloupecká, Ema - Kozák, Jaroslav - Kozic, Ján - Vedadi, M. - Weber, Jan - Mertlíková-Kaiserová, Helena - Nencka, Radim
Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors.
ACS Omega. Roč. 8, č. 30 (2023), s. 27410-27418. ISSN 2470-1343. E-ISSN 2470-1343
R&D Projects: GA MZd(CZ) NU20-05-00472; GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963
Keywords : SARS-CoV-2 * genetics * inhibitors
OECD category: Virology
Impact factor: 4.1, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acsomega.3c02815
Permanent Link: https://hdl.handle.net/11104/0344580File Download Size Commentary Version Access acsomega.3c02815 (2).pdf 0 5.1 MB Publisher’s postprint open-access - 4.0571446 - ÚOCHB 2024 RIV US eng J - Journal Article
Šilhán, Jan - Klíma, Martin - Otava, Tomáš - Škvára, Petr - Chalupská, Dominika - Chalupský, Karel - Kozic, Ján - Nencka, Radim - Bouřa, Evžen
Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Nature Communications. Roč. 14, April (2023), č. článku 2259. E-ISSN 2041-1723
R&D Projects: GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963
Keywords : messenger RNA * recognition * binding
OECD category: Virology
Impact factor: 16.6, year: 2022
Method of publishing: Open access
https://doi.org/10.1038/s41467-023-38019-1
Permanent Link: https://hdl.handle.net/11104/0342665File Download Size Commentary Version Access 10.1038s41467-023-38019-1.pdf 0 1.9 MB Publisher’s postprint open-access - 5.0555984 - ÚOCHB 2023 RIV GB eng J - Journal Article
Nencka, Radim - Šilhán, Jan - Klíma, Martin - Otava, Tomáš - Kocek, Hugo - Krafčíková, Petra - Bouřa, Evžen
Coronaviral RNA-methyltransferases: function, structure and inhibition.
Nucleic Acids Research. Roč. 50, č. 2 (2022), s. 635-650. ISSN 0305-1048. E-ISSN 1362-4962
R&D Projects: GA ČR(CZ) GA21-25280S; GA MZd(CZ) NU20-05-00472; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : structure guided design * SARS coronavirus * SARS-CoV-2 replication
OECD category: Biochemistry and molecular biology
Impact factor: 14.9, year: 2022
Method of publishing: Open access
https://doi.org/10.1093/nar/gkab1279
Permanent Link: http://hdl.handle.net/11104/0330958 - 6.0544555 - ÚOCHB 2022 RIV US eng J - Journal Article
Otava, Tomáš - Šála, Michal - Li, F. - Fanfrlík, Jindřich - Devkota, K. - Perveen, S. - Chau, I. - Pakarian, P. - Hobza, Pavel - Vedadi, M. - Bouřa, Evžen - Nencka, Radim
The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors.
ACS Infectious Diseases. Roč. 7, č. 8 (2021), s. 2214-2220. ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA MZd(CZ) NU20-05-00472
Institutional support: RVO:61388963
Keywords : COVID-19 * SARS-CoV-2 * methyltransferase * nsp14 nsp10 * structure-based design * inhibitors
OECD category: Microbiology
Impact factor: 5.578, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acsinfecdis.1c00131
Permanent Link: http://hdl.handle.net/11104/0321402