Search results
- 1.0583653 - BC 2024 RIV US eng J - Journal Article
Schwark, M. - Yerena, Jose Alberto Martinez - Roehrborn, K. - Hrouzek, P. - Divoká, P. - Štenclová, Lenka - Delawská, K. - Enke, H. - Vorreiter, C. - Wiley, F. - Sippl, W. - Sobotka, R. - Saha, S. - Wilde, S. B. - Mareš, Jan - Niedermeyer, T. H. J.
More than just an eagle killer: The freshwater cyanobacterium iAetokthonos hydrillicola/i produces highly toxic dolastatin derivatives.
Proceedings of the National Academy of Sciences of the United States of America. Roč. 120, č. 40 (2023), č. článku e2219230120. ISSN 0027-8424. E-ISSN 1091-6490
R&D Projects: GA ČR(CZ) GC19-21649J
Institutional support: RVO:60077344
Keywords : antineoplastic agents * anticancer * inhibition * tubulin * cyanotoxin * cytotoxicity * aetokthonostatin * dolastatin
OECD category: Marine biology, freshwater biology, limnology
Impact factor: 11.1, year: 2022
Method of publishing: Open access
https://doi.org/10.1073/pnas.2219230120
Permanent Link: https://hdl.handle.net/11104/0351681 - 2.0582379 - BTÚ 2024 RIV CH eng J - Journal Article
Baselious, F. - Hilscher, S. - Robaa, D. - Bařinka, Cyril - Schutkowski, M. - Sippl, W.
Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor.
International Journal of Molecular Sciences. Roč. 25, č. 2 (2024), č. článku 1358. ISSN 1661-6596
Institutional support: RVO:86652036
Keywords : AlphaFold * virtual screening * modelling * HDAC11
OECD category: Biochemistry and molecular biology
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://www.mdpi.com/1422-0067/25/2/1358
Permanent Link: https://hdl.handle.net/11104/0350507 - 3.0582359 - MBÚ 2024 RIV US eng J - Journal Article
Schwark, M. - Martinez Yerena, Jose A. - Roehrborn, K. - Hrouzek, Pavel - Divoká, Petra - Štenclová, L. - Delawská, Kateřina - Enke, H. - Vorreiter, C. - Wiley, F. - Sippl, W. - Sobotka, Roman - Saha, Subhasish - Wilde, Susan B. - Mareš, Jan - Niedermeyer, T. H. J.
More than just an eagle killer: The freshwater cyanobacterium Aetokthonos hydrillicola produces highly toxic dolastatin derivatives.
Proceedings of the National Academy of Sciences of the United States of America. Roč. 120, č. 40 (2023), č. článku e2219230120. ISSN 0027-8424. E-ISSN 1091-6490
R&D Projects: GA ČR(CZ) GC19-21649J
Institutional support: RVO:61388971
Keywords : antineoplastic agents * marine * anticancer * analog * inhibition * tubulin * biosynthesis * efficacy * targets * binding * cyanotoxin * cytotoxicity * aetokthonostatin * dolastatin * biosynthesis
OECD category: Microbiology
Impact factor: 11.1, year: 2022
Method of publishing: Open access
https://www.pnas.org/doi/10.1073/pnas.2219230120
Permanent Link: https://hdl.handle.net/11104/0350572 - 4.0579099 - ÚMG 2024 RIV US eng J - Journal Article
Kutil, Z. - Mikešová, J. - Zessin, M. - Meleshin, M. - Nováková, Z. - Alquicer, Glenda - Kozikowski, A. - Sippl, W. - Bařinka, C. - Schutkowski, M.
Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC Inhibitors.
ACS Omega. Roč. 4, č. 22 (2019), s. 19895-19904. ISSN 2470-1343. E-ISSN 2470-1343
R&D Projects: GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:68378050
Keywords : histone deacetylase inhibitors * sir2 family * posttranslational modifications * fluorescent-probe * peptide arrays * in-vitro * substrate-specificity * metabolic-regulation * fluorogenic probe * activity profiles
OECD category: Biochemistry and molecular biology
Impact factor: 2.870, year: 2019
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acsomega.9b02808
Permanent Link: https://hdl.handle.net/11104/0347965 - 5.0558797 - BTÚ 2023 RIV US eng J - Journal Article
Zessin, M. - Meleshin, M. - Praetorius, L. - Sippl, W. - Bařinka, Cyril - Schutkowski, M.
Uncovering Robust Delactoylase and Depyruvoylase Activities of HDAC Isoforms.
ACS Chemical Biology. Roč. 17, č. 6 (2022), s. 1364-1375. ISSN 1554-8929. E-ISSN 1554-8937
R&D Projects: GA ČR(CZ) GA21-31806S
Institutional support: RVO:86652036
Keywords : histone crotonylation * lysine * inhibitor * substrate
OECD category: Biochemistry and molecular biology
Impact factor: 4, year: 2022
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acschembio.1c00863
Permanent Link: https://hdl.handle.net/11104/0332584 - 6.0555060 - BTÚ 2023 RIV CH eng J - Journal Article
Ibrahim, H. - Abdelsalam, M. - Zeyn, Y. - Zessin, M. - Mustafa, A. - Fischer, M. - Zeyen, P. - Sun, P. - Buelbuel, E. - Vecchio, A. - Erdmann, F. - Schmidt, M. - Robaa, D. - Bařinka, Cyril - Romier, C. - Schutkowski, M. - Kraemer, O. - Sippl, W.
Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity.
International Journal of Molecular Sciences. Roč. 23, č. 1 (2022), č. článku 369. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA21-31806S
Institutional support: RVO:86652036
Keywords : EFFICIENT GENERATION * EPIGENETIC THERAPY * AM1-BCC MODEL
OECD category: Biochemistry and molecular biology
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://www.mdpi.com/1422-0067/23/1/369
Permanent Link: http://hdl.handle.net/11104/0332121 - 7.0548916 - BTÚ 2022 RIV NL eng J - Journal Article
Zessin, M. - Meleshin, M. - Simic, Z. - Kalbas, D. - Arbach, M. - Gebhardt, P. - Melesina, J. - Liebscher, S. - Bordusa, F. - Sippl, W. - Bařinka, Cyril - Schutkowski, M.
Continuous Sirtuin/HDAC (histone deacetylase) activity assay using thioamides as PET (Photoinduced Electron Transfer)-based fluorescence quencher.
Bioorganic Chemistry. Roč. 117, DEC 2021 (2021). ISSN 0045-2068. E-ISSN 1090-2120
Institutional support: RVO:86652036
Keywords : Sirtuin assay * HDAC11 assay * Thioamide
OECD category: Organic chemistry
Impact factor: 5.307, year: 2021
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S0045206821008026?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0324965 - 8.0519605 - BTÚ 2020 RIV US eng J - Journal Article
Kutil, Zsofia - Mikesova, Jana - Zessin, M. - Meleshin, M. - Nováková, Zora - Alquicer, Glenda - Kozikowski, A. - Sippl, W. - Bařinka, Cyril - Schutkowski, M.
Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC Inhibitors.
ACS Omega. Roč. 4, č. 22 (2019), s. 19895-19904. ISSN 2470-1343. E-ISSN 2470-1343
R&D Projects: GA ČR GA15-19640S; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:86652036
Keywords : histone deacetylase inhibitors * sir2 family * POSTTRANSLATIONAL MODIFICATIONS
OECD category: Biochemistry and molecular biology
Impact factor: 2.870, year: 2019
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acsomega.9b02808
Permanent Link: http://hdl.handle.net/11104/0305194 - 9.0519596 - BTÚ 2020 RIV US eng J - Journal Article
Zessin, M. - Kutil, Zsofia - Meleshin, M. - Nováková, Zora - Ghazy, E. - Kalbas, D. - Marek, M. - Romier, Ch. - Sippl, W. - Bařinka, Cyril - Schutkowski, M.
One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity.
Biochemistry. Roč. 58, č. 48 (2019), s. 4777-4789. ISSN 0006-2960
R&D Projects: GA ČR GA15-19640S; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:86652036
Keywords : fluorescence quenching probes * epsilon-thioacetyl-lysine * deacetylase assay * sir2 family
OECD category: Biochemistry and molecular biology
Impact factor: 2.865, year: 2019
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acs.biochem.9b00786
Permanent Link: http://hdl.handle.net/11104/0304590