Search results
- 1.0586002 - ÚOCHB 2025 RIV US eng J - Journal Article
Spiwoková, Petra - Horn, Martin - Fanfrlík, Jindřich - Jílková, Adéla - Fajtová, Pavla - Leontovyč, Adrian - Houštecká, Radka - Bieliková, Lucia - Brynda, Jiří - Chanová, M. - Mertlíková-Kaiserová, Helena - Diaz-Caro, E. J. E. - Almaliti, J. - El Sakkary, N. - Gerwick, W. H. - Caffrey, C. R. - Mareš, Michael
Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis.
ACS Infectious Diseases. (2024). ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) LTAUSA19109; GA MŠMT(CZ) LUAUS23050; GA MZd(CZ) NV18-05-00345
Institutional support: RVO:61388963
Keywords : cathepsin B * cysteine protease * drug target * parasite * Schistosoma mansoni * acrylamide inhibitor
Impact factor: 5.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acsinfecdis.3c00589
Permanent Link: https://hdl.handle.net/11104/0353623 - 2.0569875 - ÚOCHB 2024 RIV AU eng J - Journal Article
Peterková, K. - Vorel, J. - Ilgová, J. - Ostašov, P. - Fajtová, Pavla - Konečný, L. - Chanová, M. - Kašný, M. - Horn, Martin - Dvořák, Jan
Proteases and their inhibitors involved in Schistosoma mansoni egg-host interaction revealed by comparative transcriptomics with Fasciola hepatica eggs.
International Journal for Parasitology. Roč. 53, 5/6 (2023), s. 253-263. ISSN 0020-7519. E-ISSN 1879-0135
R&D Projects: GA MŠMT(CZ) LM2018131; GA ČR(CZ) GA19-17269S; GA MZd(CZ) NV18-05-00345
Research Infrastructure: e-INFRA CZ - 90140
Institutional support: RVO:61388963
Keywords : Schistosoma mansoni * egg * Fasciola hepatica * comparative transcriptomics * protease * protease inhibitor
OECD category: Biochemistry and molecular biology
Impact factor: 4, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.ijpara.2022.12.007
Permanent Link: https://hdl.handle.net/11104/0341213
Research data: NCBI BioProject - 3.0568192 - ÚOCHB 2024 RIV GB eng J - Journal Article
Boateng, E. M. - Dvořák, Jan - Ayi, I. - Chanová, M.
A literature review of schistosomiasis in Ghana: a reference for bridging the research and control gap.
Transactions of the Royal Society of Tropical Medicine and Hygiene. Roč. 117, č. 6 (2023), s. 407-417. ISSN 0035-9203. E-ISSN 1878-3503
R&D Projects: GA MZd(CZ) NV18-05-00345
Institutional support: RVO:61388963
Keywords : disease control strategies * Ghana * mass drug administration * neglected tropical disease * schistosoma * zoonosis
OECD category: Biochemistry and molecular biology
Impact factor: 2.2, year: 2022
Method of publishing: Open access
https://doi.org/10.1093/trstmh/trac134
Permanent Link: https://hdl.handle.net/11104/0339522 - 4.0543094 - ÚOCHB 2022 RIV GB eng J - Journal Article
Ulrychová, Lenka - Ostašov, P. - Chanová, M. - Mareš, Michael - Horn, Martin - Dvořák, J.
Spatial expression pattern of serine proteases in the blood fluke Schistosoma mansoni determined by fluorescence RNA in situ hybridization.
Parasites & Vectors. Roč. 14, č. 1 (2021), č. článku 274. ISSN 1756-3305. E-ISSN 1756-3305
R&D Projects: GA MZd(CZ) NV18-05-00345; GA ČR(CZ) GA19-17269S; GA MŠMT(CZ) 8J19AT036
Institutional support: RVO:61388963
Keywords : blood fluke * fluorescence RNA in situ hybridization * mRNA detection * platyhelminthes * Schistosoma mansoni * serine proteases * transcript
OECD category: Biochemistry and molecular biology
Impact factor: 4.052, year: 2021
Method of publishing: Open access
https://doi.org/10.1186/s13071-021-04773-8
Permanent Link: http://hdl.handle.net/11104/0320382 - 5.0540888 - ÚOCHB 2022 RIV US eng J - Journal Article
Jílková, Adéla - Rubešová, Petra - Fanfrlík, Jindřich - Fajtová, Pavla - Řezáčová, Pavlína - Brynda, Jiří - Lepšík, Martin - Mertlíková-Kaiserová, Helena - Emal, C. D. - Renslo, A. R. - Roush, W. R. - Horn, Martin - Caffrey, C. R. - Mareš, Michael
Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors.
ACS Infectious Diseases. Roč. 7, č. 5 (2021), s. 1077-1088. ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) LTAUSA19109; GA MŠMT(CZ) LH15040; GA MŠMT LO1302; GA MZd(CZ) NV18-05-00345; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LO1304
Institutional support: RVO:61388963
Keywords : cathepsin B * cysteine peptidase * drug target * parasite * Schistosoma mansoni * vinyl sulfone inhibitor
OECD category: Biochemistry and molecular biology
Impact factor: 5.578, year: 2021
Method of publishing: Open access
https://doi.org/10.1021/acsinfecdis.0c00501
Permanent Link: http://hdl.handle.net/11104/0318491 - 6.0538821 - ÚOCHB 2022 RIV US eng J - Journal Article
Jílková, Adéla - Horn, Martin - Fanfrlík, Jindřich - Küppers, J. - Pachl, Petr - Řezáčová, Pavlína - Lepšík, Martin - Fajtová, Pavla - Rubešová, Petra - Chanová, M. - Caffrey, C. R. - Gütschow, M. - Mareš, Michael
Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity.
ACS Infectious Diseases. Roč. 7, č. 1 (2021), s. 189-201. ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) LTAUSA19109; GA MZd(CZ) NV18-05-00345; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : azapeptide inhibitors * cysteine proteases * protein structures * structure-activity relationships * schistosomiasis
OECD category: Biochemistry and molecular biology
Impact factor: 5.578, year: 2021
Method of publishing: Open access
https://doi.org/10.1021/acsinfecdis.0c00644
Permanent Link: http://hdl.handle.net/11104/0316970