Search results
- 1.0587109 - ÚEM 2025 RIV NL eng J - Journal Article
Chvojková, M. - Kolář, D. - Kováčová, K. - Čejková, L. - Misiachna, Anna - Hakenová, K. - Gorecki, L. - Horák, Martin - Korabecný, J. - Soukup, O. - Valeš, K.
Pro-cognitive effects of dual tacrine derivatives acting as cholinesterase inhibitors and NMDA receptor antagonists.
Biomedicine & Pharmacotherapy. Roč. 176, July (2024), č. článku 116821. ISSN 0753-3322. E-ISSN 1950-6007
R&D Projects: GA MŠMT(CZ) LX22NPO5107; GA MŠMT(CZ) EH22_008/0004562
Institutional support: RVO:68378041
Keywords : acetylcholinesterase * alzheimer disease * cognition * polypharmacology * receptors * N-Methyl-D-Aspartate * tacrine
OECD category: Neurosciences (including psychophysiology
Impact factor: 7.5, year: 2022
https://www.sciencedirect.com/science/article/pii/S0753332224007054?via%3Dihub
Permanent Link: https://hdl.handle.net/11104/0354401File Download Size Commentary Version Access Chvojková 2024.pdf 0 1.8 MB Publisher’s postprint open-access - 2.0585864 - ÚEM 2025 RIV CH eng J - Journal Article
Romanyuk, Nataliya - Šintáková, Kristýna - Arzhanov, Ivan - Horák, Martin - Gandhi, Ch. - Jhanwar-Uniyal, M. - Jendelová, Pavla
mTOR pathway inhibition alters proliferation as well as differentiation of neural stem cells.
Frontiers in Cellular Neuroscience. Roč. 18, May (2024). E-ISSN 1662-5102
R&D Projects: GA MŠMT(CZ) LX22NPO5107
Institutional support: RVO:68378041
Keywords : neural stem cells * mTOR * proliferation * differentiation * cytoskeletal proteins
OECD category: Neurosciences (including psychophysiology
Impact factor: 5.3, year: 2022
https://www.frontiersin.org/articles/10.3389/fncel.2024.1298182/full
Permanent Link: https://hdl.handle.net/11104/0353515File Download Size Commentary Version Access Romanyuk 2024.pdf 2 4.4 MB Publisher’s postprint open-access - 3.0584241 - ÚEM 2025 RIV NL eng J - Journal Article
Mezeiová, E. - Prchal, L. - Hrabinová, M. - Mucková, L. - Pulkrabková, L. - Soukup, O. - Misiachna, Anna - Janoušek, J. - Fibigar, J. - Kučera, T. - Horák, Martin - Makhaeva, G.F. - Korabecný, J.
Morphing cholinesterase inhibitor amiridine into multipotent drugs for the
treatment of Alzheimer’s disease.
Biomedicine & Pharmacotherapy. Roč. 173, april. (2024), č. článku 116399. ISSN 0753-3322. E-ISSN 1950-6007
R&D Projects: GA ČR(CZ) GA22-24384S; GA MŠMT(CZ) EH22_008/0004562
Institutional support: RVO:68378041
Keywords : amiridine * acetylcholinesterase * antioxidant capacity * butyrylcholinesterase * multi-target directed ligands * NMDA receptors
OECD category: Neurosciences (including psychophysiology
Impact factor: 7.5, year: 2022
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S075333222400283X?via%3Dihub
Permanent Link: https://hdl.handle.net/11104/0352201File Download Size Commentary Version Access Mezeirová 2024.pdf 3 1.7 MB Publisher’s postprint open-access - 4.0582133 - ÚEM 2025 RIV NL eng J - Journal Article
Misiachna, Anna - Svobodová, B. - Netolický, Jakub - Chvojková, M. - Kletečková, L. - Prchal, L. - Novák, M. - Hrabinová, M. - Kučera, T. - Mucková, L. - Moravcová, Z. - Karasová-Ždárová, J. - Pejchal, J. - Blažek, F. - Maliňák, D. - Hakenová, K. - Hrčka Krausová, Barbora - Kolcheva, Marharyta - Ladislav, Marek - Korábečný, J. - Pahnke, J. - Valeš, K. - Horák, Martin - Soukup, O.
Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition.
European Journal of Medicinal Chemistry. Roč. 266, feb. (2024), č. článku 116130. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA TA ČR(CZ) TO01000078; GA MŠMT(CZ) EH22_008/0004562
Institutional support: RVO:68378041
OECD category: Neurosciences (including psychophysiology
Impact factor: 6.7, year: 2022
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S0223523424000102?via%3Dihub https://doi.org/10.5281/zenodo.10949371 https://doi.org/10.2139/ssrn.4658299
Permanent Link: https://hdl.handle.net/11104/0350209File Download Size Commentary Version Access Misiachna příloha 2024.pdf 1 9.8 MB Other open-access Misiachna 2024.pdf 4 5 MB Publisher’s postprint open-access - 5.0574116 - ÚEM 2024 RIV US eng J - Journal Article
Kortus, Štěpán - Řeháková, Kristýna - Klíma, Martin - Kolcheva, Marharyta - Ladislav, Marek - Langore, Emily - Baráčková, Petra - Netolický, Jakub - Misiachna, Anna - Hemelíková, Katarína - Humpolíčková, Jana - Chalupská, Dominika - Šilhán, Jan - Kaniaková, Martina - Hrčka Krausová, Barbora - Bouřa, Evžen - Zápotocký, Martin - Horák, Martin
Subunit-Dependent Surface Mobility and Localization of NMDA Receptors in Hippocampal Neurons Measured Using Nanobody Probes.
Journal of Neuroscience. Roč. 43, č. 26 (2023), s. 4755-4774. ISSN 0270-6474. E-ISSN 1529-2401
R&D Projects: GA ČR(CZ) GA20-12420S; GA MŠMT(CZ) LX22NPO5107
Research Infrastructure: Czech-BioImaging III - 90250; Czech-BioImaging II - 90129
Institutional support: RVO:68378041 ; RVO:61388963 ; RVO:67985823
Keywords : GluN subunit * excitatory synapse * glutamate receptor * lateral diffusion * live microscopy * mammalian neuron
OECD category: Neurosciences (including psychophysiology; Biochemistry and molecular biology (UOCHB-X); Biochemistry and molecular biology (FGU-C)
Impact factor: 5.3, year: 2022
Method of publishing: Open access
https://www.jneurosci.org/content/43/26/4755
Permanent Link: https://hdl.handle.net/11104/0344475File Download Size Commentary Version Access Kortus 2023.pdf 4 4.6 MB Publisher’s postprint open-access - 6.0572189 - ÚEM 2024 RIV CH eng J - Journal Article
Svobodová, B. - Pulkrabová, L. - Pánek, D. - Misiachna, Anna - Kolcheva, Marharyta - Andrýs, R. - Handl, J. - Čapek, J. - Nývltová, P. - Roušar, T. - Prchal, L. - Hepnarová, V. - Hrabinová, M. - Mucková, L. - Tosnerová, D. - Karabanovich, G. - Finger, V. - Soukup, O. - Horák, Martin - Korabecný, J.
Structure-Guided Design of N-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer’s Disease.
International Journal of Molecular Sciences. Roč. 24, č. 11 (2023), č. článku 9124. ISSN 1661-6596
R&D Projects: GA ČR(CZ) GA22-24384S; GA MŠMT(CZ) LX22NPO5107
Institutional support: RVO:68378041
Keywords : Alzheimer’s disease * acetylcholinesterase * enzyme inhibition * N-methyl-d-aspartate receptor * multi-target directed ligands * monoamine oxidase A/B
OECD category: Pharmacology and pharmacy
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/ijms24119124
Permanent Link: https://hdl.handle.net/11104/0342960File Download Size Commentary Version Access Svobodová 2023.pdf 2 3.8 MB Publisher’s postprint open-access - 7.0570624 - ÚEM 2024 RIV GB eng J - Journal Article
Kolcheva, Marharyta - Ladislav, Marek - Netolický, Jakub - Kortus, Štěpán - Řeháková, Kristýna - Hrčka Krausová, Barbora - Hemeliková, Katarina - Misiachna, Anna - Kádková, Anna - Klíma, M. - Chalupská, D. - Horák, Martin
The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors.
Neuropharmacology. Roč. 222, jan. (2023), č. článku 109297. ISSN 0028-3908. E-ISSN 1873-7064
R&D Projects: GA MŠMT(CZ) LX22NPO5107; GA ČR(CZ) GA20-12420S
Institutional support: RVO:68378041
Keywords : glutamate receptor * hippocampal neuron * neurodegeneration * ion channel * ketamine * memantine
OECD category: Neurosciences (including psychophysiology
Impact factor: 4.7, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.neuropharm.2022.109297
Permanent Link: https://hdl.handle.net/11104/0341931Review Download Size Commentary Version Access Kolcheva 2023.pdf 8 7.8 MB Publisher’s postprint open-access - 8.0551559 - ÚEM 2022 RIV CH eng J - Journal Article
Horák, Martin - Baráčková, Petra - Langore, Emily - Netolický, Jakub - Rivas-Ramirez, Paula - Řeháková, Kristýna
The Extracellular Domains of GluN Subunits Play an Essential Role in Processing NMDA Receptors in the ER.
Frontiers in Neuroscience. Roč. 15, mar. (2021), č. článku 603715. E-ISSN 1662-453X
R&D Projects: GA ČR(CZ) GA20-12420S
Institutional support: RVO:68378041
Keywords : disulfide bridges * glutamate receptor * glycosylation * excitatory synapse * posttranslational modification
OECD category: Neurosciences (including psychophysiology
Impact factor: 5.152, year: 2021
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fnins.2021.603715/full
Permanent Link: http://hdl.handle.net/11104/0326822 - 9.0551558 - ÚEM 2022 RIV FR eng J - Journal Article
Gorecki, L. - Misiachna, Anna - Damborský, J. - Doležal, R. - Korábečný, J. - Čejková, L. - Hakenová, K. - Chvojková, M. - Zdarová Karasová, J. - Prchal, L. - Novák, M. - Kolcheva, Marharyta - Kortus, Štěpán - Valeš, K. - Horák, Martin - Soukup, O.
Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-D-Aspartate receptors.
European Journal of Medicinal Chemistry. Roč. 219, 5 july (2021), č. článku 113434. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA20-12047S; GA TA ČR(CZ) TO01000078
Institutional support: RVO:68378041
Keywords : QSAR * acetylcholinesterase * electrophysiology * glutamate receptor * ion channel * pharmacologyin vivo * tacrine
OECD category: Medicinal chemistry
Impact factor: 7.088, year: 2021
Method of publishing: Open access
https://doi.org/10.1016/j.ejmech.2021.113434
Permanent Link: http://hdl.handle.net/11104/0326821 - 10.0543492 - ÚEM 2022 RIV US eng J - Journal Article
Kaniaková, Martina - Korábečný, J. - Holubová, K. - Kletečková, L. - Chvojková, M. - Hakenová, K. - Prchal, L. - Novák, M. - Doležal, R. - Hepnarová, V. - Svobodová, B. - Kučera, T. - Lichnerová, Katarina - Hrčka Krausová, Barbora - Horák, Martin - Valeš, K. - Soukup, O.
7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo.
Biochemical Pharmacology. Roč. 186, apr. (2021), č. článku 114460. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA ČR(CZ) GA20-12047S
Institutional support: RVO:68378041
Keywords : behavioral experiment * electrophysiology * glutamate receptor * mutation * ion channel * acetylcholinesterase
OECD category: Pharmacology and pharmacy
Impact factor: 6.100, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.bcp.2021.114460
Permanent Link: http://hdl.handle.net/11104/0320802