Search results
- 1.0524902 - FGÚ 2021 RIV US eng J - Journal Article
Randáková, Alena - Nelic, Dominik - Doležal, Vladimír - El-Fakahany, E. E. - Boulos, J. - Jakubík, Jan
Agonist-Specific Conformations of the M-2 Muscarinic Acetylcholine Receptor Assessed by Molecular Dynamics.
Journal of Chemical Information and Modeling. Roč. 60, č. 4 (2020), s. 2325-2338. ISSN 1549-9596. E-ISSN 1549-960X
R&D Projects: GA ČR(CZ) GA17-16182S; GA ČR(CZ) GJ19-06106Y
Research Infrastructure: CESNET II - 90042
Institutional support: RVO:67985823
Keywords : muscarinic receptors * agonist-specific conformations * signalling bias * accelerated molecular dynamics
OECD category: Pharmacology and pharmacy
Impact factor: 4.956, year: 2020
Method of publishing: Limited access
https://doi.org/10.1021/acs.jcim.0c00041
Permanent Link: http://hdl.handle.net/11104/0309133 - 2.0524282 - FGÚ 2021 RIV GB eng J - Journal Article
Randáková, Alena - Nelic, Dominik - Ungerová, Dana - Nwokoye, P. - Su, Q. - Doležal, Vladimír - El-Fakahany, E. E. - Boulos, J. - Jakubík, Jan
Novel M-2-selective, G(i)-biased agonists of muscarinic acetylcholine receptors.
British Journal of Pharmacology. Roč. 177, č. 9 (2020), s. 2073-2089. ISSN 0007-1188. E-ISSN 1476-5381
R&D Projects: GA ČR(CZ) GA17-16182S
Research Infrastructure: CESNET II - 90042
Institutional support: RVO:67985823
Keywords : muscarinic acetylcholine receptors * functionally selective agonists * signalling bias
OECD category: Physiology (including cytology)
Impact factor: 8.740, year: 2020
Method of publishing: Limited access
https://doi.org/10.1111/bph.14970
Permanent Link: http://hdl.handle.net/11104/0308655 - 3.0504453 - FGÚ 2020 RIV GB eng J - Journal Article
Jakubík, Jan - Randáková, Alena - Rudajev, Vladimír - Zimčík, Pavel - El-Fakahany, E. E. - Doležal, Vladimír
Applications and limitations of fitting of the operational model to determine relative efficacies of agonists.
Scientific Reports. Roč. 9, Mar 15 (2019), č. článku 4637. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR(CZ) GA17-16182S
Institutional support: RVO:67985823
Keywords : operational model of agonism * affinity * efficacy
OECD category: Physiology (including cytology)
Impact factor: 3.998, year: 2019
Method of publishing: Open access
https://doi.org/10.1038/s41598-019-40993-w
Permanent Link: http://hdl.handle.net/11104/0296081 - 4.0490235 - FGÚ 2019 RIV GB eng J - Journal Article
Randáková, Alena - Rudajev, Vladimír - Doležal, Vladimír - Boulos, J. - Jakubík, Jan
Novel long‐acting antagonists of muscarinic ACh receptors.
British Journal of Pharmacology. Roč. 175, č. 10 (2018), s. 1731-1743. ISSN 0007-1188. E-ISSN 1476-5381
R&D Projects: GA ČR(CZ) GA17-16182S
Institutional support: RVO:67985823
Keywords : muscarinic acetylcholine receptors * long-acting antagonists * tetrahydropyridinium slats
OECD category: Physiology (including cytology)
Impact factor: 6.583, year: 2018
Permanent Link: http://hdl.handle.net/11104/0284504 - 5.0489273 - FGÚ 2019 RIV NL eng J - Journal Article
Randáková, Alena - Dolejší, Eva - Rudajev, Vladimír - Zimčík, Pavel - Doležal, Vladimír - El-Fakahany, E. E. - Jakubík, Jan
Role of membrane cholesterol in differential sensitivity of muscarinic receptor subtypes to persistently bound xanomeline.
Neuropharmacology. Roč. 133, May 1 (2018), s. 129-144. ISSN 0028-3908. E-ISSN 1873-7064
R&D Projects: GA ČR(CZ) GA14-05696S; GA ČR(CZ) GA17-16182S
Institutional support: RVO:67985823
Keywords : muscarinic acetylcholine receptors * membrane cholesterol * xanomeline * receptor activation * molecular dynamics
OECD category: Physiology (including cytology)
Impact factor: 4.367, year: 2018
Permanent Link: http://hdl.handle.net/11104/0283716