Search results
- 1.0545890 - ÚEB 2022 RIV GB eng J - Journal Article
Maková, B. - Mik, V. - Lišková, B. - Gonzalez, G. - Vítek, D. - Medvedíková, M. - Monfort, B. - Ručilová, V. - Kadlecová, A. - Khirsariya, P. - Gándara Barreiro, Z. - Havlíček, Libor - Zatloukal, M. - Soural, M. - Paruch, K. - D'Autréaux, B. - Hajdúch, M. - Strnad, M. - Voller, Jiří
Cytoprotective activities of kinetin purine isosteres.
Bioorganic & Medicinal Chemistry. Roč. 33, MAR 1 (2021), č. článku 115993. ISSN 0968-0896. E-ISSN 1464-3391
Institutional support: RVO:61389030
Keywords : bioisostery – Friedreich́s ataxia * Cytokinin * Kinetin * Mitoprotection – familial dysautonomia * Neuroprotection
OECD category: Pharmacology and pharmacy
Impact factor: 3.461, year: 2021
Method of publishing: Open access
http://doi.org/10.1016/j.bmc.2021.115993
Permanent Link: http://hdl.handle.net/11104/0322516File Download Size Commentary Version Access 2021_Makova_BIOORGANIC & MEDICINAL CHEMISTRY_115993.pdf 1 1.1 MB Other open-access - 2.0534033 - BFÚ 2021 RIV NL eng J - Journal Article
Drápela, Stanislav - Khirsariya, P. - van Weerden, W. - Fedr, Radek - Suchánková, Tereza - Búzová, Diana - Červený, Jan - Hampl, A. - Puhr, M. - Watson, W. R. - Culig, Z. - Krejčí, L. - Paruch, K. - Souček, Karel
The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe.
Molecular Oncology. Roč. 14, č. 10 (2020), s. 2487-2503. ISSN 1574-7891. E-ISSN 1878-0261
R&D Projects: GA MZd(CZ) NV18-08-00245; GA MZd(CZ) NV17-28518A
Institutional support: RVO:68081707 ; RVO:86652079
Keywords : dna-damage response * checkpoint kinase 1 * replication * initiation
OECD category: Plant sciences, botany; Plant sciences, botany (UEK-B)
Impact factor: 6.603, year: 2020
Method of publishing: Open access
https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.12756
Permanent Link: http://hdl.handle.net/11104/0312249 - 3.0523189 - BFÚ 2020 RIV IT eng J - Journal Article
Boudny, M. - Zemanová, J. - Khirsariya, P. - Borský, M. - Verner, J. - Černá, J. - Oltová, A. - Seda, V. - Mráz, M. - Jaros, J. - Jaskova, Z. - Spunarova, M. - Brychtová, Y. - Souček, Karel - Drápela, Stanislav - Kasparkova, M. - Mayer, J. - Paruch, K. - Trbusek, M.
Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells.
Haematologica-The Hematology Journal. Roč. 104, č. 12 (2019), s. 2443-2455. ISSN 0390-6078
R&D Projects: GA MZd(CZ) NV15-33999A
Institutional support: RVO:68081707
Keywords : in-vitro * kinase * cll
OECD category: Hematology
Impact factor: 7.116, year: 2019
Method of publishing: Open access
http://www.haematologica.org/content/104/12/2443
Permanent Link: http://hdl.handle.net/11104/0307575 - 4.0485556 - BFÚ 2018 RIV US eng J - Journal Article
Samadder, P. - Suchánková, Tereza - Hylse, O. - Khirsariya, P. - Nikulenkov, F. - Drápela, Stanislav - Straková, Nicol - Vaňhara, P. - Vašíčková, K. - Kolářová, H. - Binó, Lucia - Bittová, M. - Ovesná, P. - Kollár, P. - Fedr, Radek - Esner, M. - Jaros, J. - Hampl, A. - Krejčí, L. - Paruch, K. - Souček, Karel
Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation.
Molecular Cancer Therapeutics. Roč. 16, č. 9 (2017), s. 1831-1842. ISSN 1535-7163. E-ISSN 1538-8514
R&D Projects: GA MZd(CZ) NV15-33999A
Institutional support: RVO:68081707
Keywords : therapeutic-efficacy * protein-kinases * targeting chk1 * cancer-therapy
OECD category: Oncology
Impact factor: 5.365, year: 2017
Permanent Link: http://hdl.handle.net/11104/0280521 - 5.0485532 - BFÚ 2018 RIV US eng J - Journal Article
Herudková, Jarmila - Paruch, K. - Khirsariya, P. - Souček, Karel - Krkoška, Martin - Blanářová, Olga - Sova, P. - Kozubík, Alois - Vaculová, Alena
Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells.
Neoplasia. Roč. 19, č. 10 (2017), s. 830-841. ISSN 1476-5586. E-ISSN 1476-5586
R&D Projects: GA ČR GA15-06650S
Institutional support: RVO:68081707
Keywords : dna-damaging agents * in-vitro * replication checkpoint
OECD category: Biochemistry and molecular biology
Impact factor: 4.994, year: 2017
Permanent Link: http://hdl.handle.net/11104/0280514 - 6.0476449 - BFÚ 2018 RIV US eng J - Journal Article
Maier, L. - Khirsariya, P. - Hylse, O. - Adla, S.K. - Cernova, L. - Poljak, M. - Krajčovičová, S. - Weis, E. - Drápela, Stanislav - Souček, Karel - Paruch, K.
Diastereoselective Flexible Synthesis of Carbocyclic C-Nucleosides.
Journal of Organic Chemistry. Roč. 82, č. 7 (2017), s. 3382-3402. ISSN 0022-3263. E-ISSN 1520-6904
Institutional support: RVO:68081707
Keywords : mitsunobu * catalysis * alcohols
OECD category: Organic chemistry
Impact factor: 4.805, year: 2017
Permanent Link: http://hdl.handle.net/11104/0272947 - 7.0476134 - ÚOCHB 2018 RIV DE eng J - Journal Article
Nekardová, Michaela - Vymětalová, Ladislava - Khirsariya, P. - Kováčová, S. - Hylsová, M. - Jorda, Radek - Kryštof, Vladimír - Fanfrlík, Jindřich - Hobza, Pavel - Paruch, K.
Structural Basis of the Interaction of Cyclin-Dependent Kinase 2 with Roscovitine and Its Analogues Having Bioisosteric Central Heterocycles.
ChemPhysChem. Roč. 18, č. 7 (2017), s. 785-795. ISSN 1439-4235. E-ISSN 1439-7641
R&D Projects: GA ČR(CZ) GBP208/12/G016; GA ČR(CZ) GA15-15264S
Institutional support: RVO:61388963 ; RVO:61389030
Keywords : computational chemistry * enzymes * protein-inhibitor interactions * purine bioisosteres * scaffold hopping
OECD category: Physical chemistry
Impact factor: 2.947, year: 2017
Permanent Link: http://hdl.handle.net/11104/0272666File Download Size Commentary Version Access 2017_Nekardova_CHEMPHYSCHEM_785.pdf 6 3.2 MB Other open-access