Search results
- 1.0572565 - ÚOCHB 2024 RIV US eng J - Journal Article
Skácel, Jan - Djukic, Stefan - Baszczyňski, Ondřej - Kalčic, Filip - Bílek, Tadeáš - Chalupský, Karel - Kozák, Jaroslav - Dvořáková, Alexandra - Tloušťová, Eva - Kráľová, Zuzana - Šmídková, Markéta - Voldřich, Jan - Rumlová, M. - Pachl, Petr - Brynda, Jiří - Vučková, Tereza - Fábry, Milan - Snášel, Jan - Pichová, Iva - Řezáčová, Pavlína - Mertlíková-Kaiserová, Helena - Janeba, Zlatko
Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors.
Journal of Medicinal Chemistry. Roč. 66, č. 10 (2023), s. 6652-6681. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA TA ČR(CZ) TN01000013; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : multisubstrate analog inhibitors * transition-state analog * human erythrocytes
OECD category: Organic chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.2c02097
Permanent Link: https://hdl.handle.net/11104/0343213File Download Size Commentary Version Access 10.1021acs.jmedchem.2c02097.pdf 1 5.7 MB Publisher’s postprint open-access - 2.0553286 - ÚOCHB 2023 RIV US eng J - Journal Article
Khatun, M. - Kumar, K. - Baidya, A. - Mondal, R. K. - Baszczyňski, Ondřej - Kalčic, Filip - Banerjee, S. - Dhali, G. K. - Das, K. - Chowdhury, A. - Janeba, Zlatko - Chakrabarti, S. - Datta, S.
Variability in the Responses of Hepatitis B Virus D-Subgenotypes to Antiviral Therapy: Designing Pan-D-Subgenotypic Reverse Transcriptase Inhibitors.
Journal of Virology. Roč. 96, č. 2 (2022), č. článku e01800-21. ISSN 0022-538X. E-ISSN 1098-5514
Institutional support: RVO:61388963
Keywords : antiviral activity * entecavir * hepatitis B virus D-subgenotypes * high throughput virtual screening * phosphonate prodrug * zenofovir
OECD category: Organic chemistry
Impact factor: 5.4, year: 2022
Method of publishing: Limited access
https://doi.org/10.1128/JVI.01800-21
Permanent Link: http://hdl.handle.net/11104/0328267 - 3.0547506 - ÚOCHB 2022 RIV US eng J - Journal Article
Kalčic, Filip - Zgarbová, Michala - Hodek, Jan - Chalupský, Karel - Dračínský, Martin - Dvořáková, Alexandra - Strmeň, Timotej - Šebestík, Jaroslav - Baszczyňski, Ondřej - Weber, Jan - Mertlíková-Kaiserová, Helena - Janeba, Zlatko
Discovery of Modified Amidate (ProTide) Prodrugs of Tenofovir with Enhanced Antiviral Properties.
Journal of Medicinal Chemistry. Roč. 64, č. 22 (2021), s. 16425-16449. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT LTAUSA18086
Institutional support: RVO:61388963
Keywords : chemistry * drug development * drug effect
OECD category: Organic chemistry
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c01444
Permanent Link: http://hdl.handle.net/11104/0323727 - 4.0545555 - ÚOCHB 2022 RIV FR eng J - Journal Article
Kalčic, Filip - Frydrych, Jan - Doleželová, Eva - Slapničková, Martina - Pachl, Petr - Poštová Slavětínská, Lenka - Dračínský, Martin - Hocková, Dana - Zíková, Alena - Janeba, Zlatko
C1′-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase.
European Journal of Medicinal Chemistry. Roč. 225, Dec 5 (2021), č. článku 113798. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) EF16_019/0000759; GA ČR(CZ) GA19-07707S
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : trypanosomiasis * purine salvage pathway * APRT * nucleotide analogues * phosphonates * enzyme inhibitors
OECD category: Organic chemistry; Microbiology (BC-A)
Impact factor: 7.088, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.ejmech.2021.113798
Permanent Link: http://hdl.handle.net/11104/0322237 - 5.0543665 - ÚOCHB 2022 RIV DE eng J - Journal Article
Kalčic, Filip - Kolman, Viktor - Zídek, Zdeněk - Janeba, Zlatko
Polysubstituted Pyrimidines as Potent Inhibitors of Prostaglandin E2 Production: Increasing Aqueous Solubility.
ChemMedChem. Roč. 16, č. 18 (2021), s. 2802-2806. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : anti-inflammatory * prostaglandin E2 * pyrimidines * solubility * synthesis
OECD category: Organic chemistry; Medicinal chemistry (UEM-P)
Impact factor: 3.540, year: 2021
Method of publishing: Limited access
https://doi.org/10.1002/cmdc.202100263
Permanent Link: http://hdl.handle.net/11104/0320847 - 6.0543050 - ÚOCHB 2022 RIV GB eng J - Journal Article
Kalčic, Filip - Dračínský, Martin - Janeba, Zlatko
Diverse synthetic approaches towards C1′-branched acyclic nucleoside phosphonates.
Organic & Biomolecular Chemistry. Roč. 19, č. 32 (2021), s. 6958-6963. ISSN 1477-0520. E-ISSN 1477-0539
R&D Projects: GA MŠMT LTAUSA18086
Institutional support: RVO:61388963
Keywords : tenofovir alafenamide * medicinal chemistry * nucleotide analogs
OECD category: Organic chemistry
Impact factor: 3.890, year: 2021
Method of publishing: Limited access
https://doi.org/10.1039/D1OB00751C
Permanent Link: http://hdl.handle.net/11104/0320358 - 7.0525593 - ÚOCHB 2021 RIV DE eng J - Journal Article
Kalčic, Filip - Kolman, Viktor - Ajani, Haresh - Zídek, Zdeněk - Janeba, Zlatko
Polysubstituted Pyrimidines as mPGES‐1 Inhibitors: Discovery of Potent Inhibitors of PGE2 Production with Strong Anti‐inflammatory Effects in Carrageenan‐Induced Rat Paw Edema.
ChemMedChem. Roč. 15, č. 15 (2020), s. 1398-1407. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : anti-inflammatory * mPGES-1 * prostaglandin E2 * pyrimidines * Suzuki Miyaura reaction
OECD category: Organic chemistry; Medicinal chemistry (UEM-P)
Impact factor: 3.466, year: 2020
Method of publishing: Limited access
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cmdc.202000258
Permanent Link: http://hdl.handle.net/11104/0309705 - 8.0493581 - ÚOCHB 2019 RIV FR eng J - Journal Article
Kolman, Viktor - Kalčic, Filip - Jansa, Petr - Zídek, Zdeněk - Janeba, Zlatko
Influence of the C-5 substitution in polysubstituted pyrimidines on inhibition of prostaglandin E2 production.
European Journal of Medicinal Chemistry. Roč. 156, Aug 5 (2018), s. 295-301. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : pyrimidines * Suzuki-Miyaura reaction * prostaglandin E2 * inhibitor
OECD category: Organic chemistry; Medicinal chemistry (UEM-P)
Impact factor: 4.833, year: 2018
Permanent Link: http://hdl.handle.net/11104/0286924 - 9.0476117 - ÚOCHB 2018 RIV NL eng J - Journal Article
Kolman, Viktor - Jansa, Petr - Kalčic, Filip - Janeba, Zlatko - Zídek, Zdeněk
Polysubstituted 4,6-bis(hetero)arylpyrimidines as dual inhibitors of nitric oxide and prostaglandin E-2 production.
Nitric Oxide-Biology and Chemistry. Roč. 67, Jul 1 (2017), s. 53-57. ISSN 1089-8603. E-ISSN 1089-8611
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : pyrimidine derivatives * nitric oxide * prostaglandin E-2 * dual inhibitors * anti-inflammatory properties
OECD category: Biochemistry and molecular biology; Organic chemistry (UEM-P)
Impact factor: 4.367, year: 2017
Permanent Link: http://hdl.handle.net/11104/0272652