Search results
- 1.0574383 - ÚOCHB 2024 RIV NL eng J - Journal Article
Dejmek, Milan - Brázdová, Andrea - Otava, Tomáš - Pimková Polidarová, Markéta - Klíma, Martin - Smola, Miroslav - Vavřina, Zdeněk - Buděšínský, Miloš - Dračínský, Martin - Liboska, Radek - Bouřa, Evžen - Birkuš, Gabriel - Nencka, Radim
Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
European Journal of Medicinal Chemistry. Roč. 259, November (2023), č. článku 115685. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) LX22NPO5103; GA MZd(CZ) NU20-05-00472
Research Infrastructure: CCP II - 90126
Institutional support: RVO:61388963
Keywords : cyclic dinucleotides * STING * cancer * intratumoral administration * immunotherapy
OECD category: Medicinal chemistry
Impact factor: 6.7, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.ejmech.2023.115685
Permanent Link: https://hdl.handle.net/11104/0344716File Download Size Commentary Version Access 10.1016j.ejmech.2023.115685.pdf 0 5.2 MB Publisher’s postprint open-access
Research data: PDB - 2.0563157 - ÚOCHB 2023 RIV US eng J - Journal Article
Vavřina, Zdeněk - Perlíková, Pavla - Milisavljevič, Nemanja - Chevrier, Florian - Smola, Miroslav - Smith, Joshua - Dejmek, Milan - Havlíček, Vojtěch - Buděšínský, Miloš - Liboska, Radek - Vaneková, Lenka - Brynda, Jiří - Bouřa, Evžen - Řezáčová, Pavlína - Hocek, Michal - Birkuš, Gabriel
Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists.
Journal of Medicinal Chemistry. Roč. 65, č. 20 (2022), s. 14082-14103. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT LX22NPO5102; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : GMP-AMP synthase * interferon genes * adapter protein
OECD category: Biochemistry and molecular biology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.2c01305
Permanent Link: https://hdl.handle.net/11104/0335201File Download Size Commentary Version Access 10.1021acs.jmedchem.2c01305.pdf 7 6.9 MB Publisher’s postprint open-access - 3.0559980 - ÚOCHB 2023 RIV GB eng J - Journal Article
Dejmek, Milan - Šála, Michal - Brázdová, Andrea - Vaneková, Lenka - Smola, Miroslav - Klíma, Martin - Břehová, Petra - Buděšínský, Miloš - Dračínský, Martin - Procházková, Eliška - Zavřel, Martin - Šimák, Ondřej - Páv, Ondřej - Bouřa, Evžen - Birkuš, Gabriel - Nencka, Radim
Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential.
Structure. Roč. 30, č. 8 (2022), s. 1146-1156. ISSN 0969-2126. E-ISSN 1878-4186
R&D Projects: GA MZd(CZ) NU20-05-00472; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : cyclic dinucleotides * prodrugs * STING agonists * isonucleosides * cytokines * cancer
OECD category: Organic chemistry
Impact factor: 5.7, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.str.2022.05.012
Permanent Link: https://hdl.handle.net/11104/0333087 - 4.0549413 - ÚOCHB 2022 RIV US eng J - Journal Article
Novotná, Barbora - Holá, Lucie - Staś, Monika - Gutten, Ondrej - Smola, Miroslav - Zavřel, Martin - Vavřina, Zdeněk - Buděšínský, Miloš - Liboska, Radek - Chevrier, Florian - Dobiaš, Juraj - Bouřa, Evžen - Rulíšek, Lubomír - Birkuš, Gabriel
Enzymatic Synthesis of 3′-5′, 3′-5′ Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
Biochemistry. Roč. 60, č. 48 (2021), s. 3714-3727. ISSN 0006-2960
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA ČR(CZ) GA20-08772S
Institutional support: RVO:61388963
Keywords : cytosolic DNA sensor * c-di-GMP * structural analysis
OECD category: Biochemistry and molecular biology
Impact factor: 3.321, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.biochem.1c00692
Permanent Link: http://hdl.handle.net/11104/0325428 - 5.0543611 - ÚOCHB 2022 RIV US eng J - Journal Article
Pimková Polidarová, Markéta - Břehová, Petra - Kaiser, Martin Maxmilian - Smola, Miroslav - Dračínský, Martin - Smith, Joshua - Marek, Aleš - Dejmek, Milan - Šála, Michal - Gutten, Ondrej - Rulíšek, Lubomír - Novotná, Barbora - Brázdová, Andrea - Janeba, Zlatko - Nencka, Radim - Bouřa, Evžen - Páv, Ondřej - Birkuš, Gabriel
Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3′,3′-c-Di(2′F,2′dAMP).
Journal of Medicinal Chemistry. Roč. 64, č. 11 (2021), s. 7596-7616. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA ČR(CZ) GA20-08772S
Institutional support: RVO:61388963
Keywords : DNA sensor * interferon genes * cyclic GMP-AMP
OECD category: Medicinal chemistry
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c00301
Permanent Link: http://hdl.handle.net/11104/0320799 - 6.0541558 - ÚOCHB 2022 RIV DE eng J - Journal Article
Smola, Miroslav - Gutten, Ondrej - Dejmek, Milan - Kožíšek, Milan - Evangelidis, Thomas - Tehrani, Zahra Aliakbar - Novotná, Barbora - Nencka, Radim - Birkuš, Gabriel - Rulíšek, Lubomír - Bouřa, Evžen
Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein.
Angewandte Chemie - International Edition. Roč. 60, č. 18 (2021), s. 10172-10178. ISSN 1433-7851. E-ISSN 1521-3773
R&D Projects: GA ČR(CZ) GA20-08772S; GA MŠMT(CZ) EF16_019/0000729
Research Infrastructure: e-INFRA CZ - 90140
Institutional support: RVO:61388963
Keywords : conformational analysis * cyclic dinucleotides * entropy * quantum chemistry * strain energy
OECD category: Physical chemistry
Impact factor: 16.823, year: 2021
Method of publishing: Open access
https://doi.org/10.1002/anie.202016805
Permanent Link: http://hdl.handle.net/11104/0319101 - 7.0541319 - ÚOCHB 2022 RIV US eng J - Journal Article
Vavřina, Zdeněk - Gutten, Ondrej - Smola, Miroslav - Zavřel, Martin - Tehrani, Zahra Aliakbar - Charvát, Vilém - Kožíšek, Milan - Bouřa, Evžen - Birkuš, Gabriel - Rulíšek, Lubomír
Protein-Ligand Interactions in the STING Binding Site Probed by Rationally Designed Single-Point Mutations: Experiment and Theory.
Biochemistry. Roč. 60, č. 8 (2021), s. 607-620. ISSN 0006-2960
R&D Projects: GA ČR(CZ) GA20-08772S; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : ligand-binding * STING protein * structural biology * QM/MM calculations
OECD category: Biochemistry and molecular biology
Impact factor: 3.321, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.biochem.0c00949
Permanent Link: http://hdl.handle.net/11104/0318895 - 8.0519394 - ÚOCHB 2021 RIV AT eng J - Journal Article
Smola, Miroslav - Horová, Vladimíra - Bouřa, Evžen - Klíma, Martin
Structural basis for hijacking of the host ACBD3 protein by bovine and porcine enteroviruses and kobuviruses.
Archives of Virology. Roč. 165, č. 2 (2020), s. 355-366. ISSN 0304-8608. E-ISSN 1432-8798
R&D Projects: GA ČR(CZ) GJ17-07058Y; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : 4-kinase III beta * 3A protein * replication
OECD category: Biochemistry and molecular biology
Impact factor: 2.574, year: 2020
Method of publishing: Limited access
https://link.springer.com/article/10.1007%2Fs00705-019-04490-9
Permanent Link: http://hdl.handle.net/11104/0304508 - 9.0519161 - ÚOCHB 2020 RIV US eng J - Journal Article
Novotná, Barbora - Vaneková, Lenka - Zavřel, Martin - Buděšínský, Miloš - Dejmek, Milan - Smola, Miroslav - Gutten, Ondrej - Tehrani, Zahra Aliakbar - Pimková Polidarová, Markéta - Brázdová, Andrea - Liboska, Radek - Štěpánek, Ivan - Vavřina, Zdeněk - Jandušík, Tomáš - Nencka, Radim - Rulíšek, Lubomír - Bouřa, Evžen - Brynda, Jiří - Páv, Ondřej - Birkuš, Gabriel
Enzymatic Preparation of 2′–5′,3′–5′-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
Journal of Medicinal Chemistry. Roč. 62, č. 23 (2019), s. 10676-10690. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA ČR(CZ) GA20-08772S
Institutional support: RVO:61388963
Keywords : cyclic GMP-AMP * cytosolic DNA sensor * di-GMP
OECD category: Organic chemistry
Impact factor: 6.205, year: 2019
Method of publishing: Limited access
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.9b01062
Permanent Link: http://hdl.handle.net/11104/0304187 - 10.0509813 - ÚOCHB 2020 RIV US eng J - Journal Article
Horová, Vladimíra - Lyoo, H. - Rozycki, B. - Chalupská, Dominika - Smola, Miroslav - Humpolíčková, Jana - Strating, J. R. P. M. - van Kuppeveld, F. J. M. - Bouřa, Evžen - Klíma, Martin
Convergent evolution in the mechanisms of ACBD3 recruitment to picornavirus replication sites.
PLoS Pathogens. Roč. 15, č. 8 (2019), č. článku e1007962. ISSN 1553-7366. E-ISSN 1553-7374
R&D Projects: GA ČR(CZ) GJ17-07058Y; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : 4 kinase III beta * protein 3A * phosphatidylinositol 4-phosphate
OECD category: Biochemistry and molecular biology
Impact factor: 6.218, year: 2019
Method of publishing: Open access
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007962
Permanent Link: http://hdl.handle.net/11104/0300432File Download Size Commentary Version Access 0509813.pdf 3 4.1 MB Publisher’s postprint open-access