Search results
- 1.0579447 - ÚOCHB 2025 RIV GB eng J - Journal Article
Misehe, Mbilo - Šála, Michal - Matoušová, Marika - Hercík, Kamil - Kocek, Hugo - Chalupská, Dominika - Chaloupecká, Ema - Hájek, Miroslav - Bouřa, Evžen - Mertlíková-Kaiserová, Helena - Nencka, Radim
Design, synthesis and evaluation of novel thieno[2,3d]pyrimidine derivatives as potent and specific RIPK2 inhibitors.
Bioorganic and Medicinal Chemistry Letters. Roč. 97, January (2024), č. článku 129567. ISSN 0960-894X. E-ISSN 1464-3405
R&D Projects: GA MZd(CZ) NU20-05-00472; GA MŠMT(CZ) LX22NPO5103
Grant - others:AV ČR(CZ) StrategieAV21/25
Program: StrategieAV
Institutional support: RVO:61388963
Keywords : kinase inhibitor * thieno [2,3d] pyrimidine derivative * receptor-interacting protein kinase 2 * RIPK2 * NOD
OECD category: Medicinal chemistry
Impact factor: 2.7, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.bmcl.2023.129567
Permanent Link: https://hdl.handle.net/11104/0348249File Download Size Commentary Version Access 10.1016j.bmcl.2023.129567.pdf 0 1.6 MB Publisher’s postprint open-access - 2.0577416 - ÚOCHB 2024 RIV CH eng J - Journal Article
Vozandychova, V. - Řehulka, P. - Hercík, Kamil - Špidlová, P. - Pavlík, P. - Hanus, J. - Hadravová, Romana - Stulík, J.
Modified activities of macrophages’ deubiquitinating enzymes after Francisella infection.
Frontiers in Immunology. Roč. 14, September (2023), č. článku 1252827. ISSN 1664-3224. E-ISSN 1664-3224
Institutional support: RVO:61388963
Keywords : Francisella * deubiquitination * DUBs * exosomes * extracellular vesicles * USP10 * UCH-l5 * USP25
OECD category: Microbiology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.3389/fimmu.2023.1252827
Permanent Link: https://hdl.handle.net/11104/0346548 - 3.0574898 - ÚOCHB 2024 RIV NL eng J - Journal Article
Misehe, Mbilo - Matoušová, Marika - Dvořáková, Alexandra - Hercík, Kamil - Škach, Kryštof - Chalupská, Dominika - Dejmek, Milan - Šála, Michal - Hájek, Miroslav - Bouřa, Evžen - Mertlíková-Kaiserová, Helena - Nencka, Radim
Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases.
European Journal of Medicinal Chemistry. Roč. 260, November (2023), č. článku 115717. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) LX22NPO5103; GA MZd(CZ) NU20-05-00472
Institutional support: RVO:61388963
Keywords : kinase inhibitor * quinazoline derivatives * RIPK2 * NOD * inflammation * RIPK3
OECD category: Medicinal chemistry
Impact factor: 6.7, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.ejmech.2023.115717
Permanent Link: https://hdl.handle.net/11104/0344824File Download Size Commentary Version Access 10.1016j.ejmech.2023.115717.pdf 0 4.4 MB Publisher’s postprint open-access - 4.0571023 - ÚOCHB 2024 RIV CH eng J - Journal Article
Santelices, J. - Ou, M. - Maegawa, G. H. B. - Hercík, Kamil - Edelmann, M. J.
USP8 inhibition regulates autophagy flux and controls Salmonella infection.
Frontiers in Cellular and Infection Microbiology. Roč. 13, March (2023), č. článku 1070271. ISSN 2235-2988. E-ISSN 2235-2988
Institutional support: RVO:61388963
Keywords : deubiquitinating enzymes * deubiquitinases * Salmonella * USP8 * autophagy * chemical proteomics
OECD category: Medicinal chemistry
Impact factor: 5.7, year: 2022
Method of publishing: Open access
https://doi.org/10.3389/fcimb.2023.1070271
Permanent Link: https://hdl.handle.net/11104/0342340
Research data: Mendeley Data - 5.0569689 - ÚOCHB 2024 RIV US eng J - Journal Article
Nuta, G. C. - Gilad, Y. - Goldberg, N. - Meril, S. - Bahlsen, M. - Carvalho, S. - Kozer, N. - Barr, H. - Sirkis, Y. F. - Hercík, Kamil - Břehová, Petra - Nencka, Radim - Bialik, S. - Eisenstein, M. - Kimchi, A.
Identifying a selective inhibitor of autophagy that targets ATG12-ATG3 protein-protein interaction.
Autophagy. Roč. 19, č. 8 (2023), s. 2372-2385. ISSN 1554-8627. E-ISSN 1554-8635
Institutional support: RVO:61388963
Keywords : autophagy inhibition * cancer * drug screen * LC3B * pancreatic cancer * protein-fragment complementation assay * small molecules
OECD category: Organic chemistry
Impact factor: 13.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1080/15548627.2023.2178159
Permanent Link: https://hdl.handle.net/11104/0341063 - 6.0541536 - ÚOCHB 2022 RIV CH eng J - Journal Article
Vozandychova, V. - Stojková, P. - Hercík, Kamil - Řehulka, P. - Stulík, J.
The Ubiquitination System within Bacterial Host–Pathogen Interactions.
Microorganisms. Roč. 9, č. 3 (2021), č. článku 638. E-ISSN 2076-2607
Institutional support: RVO:61388963
Keywords : ubiquitination * deubiquitinating enzymes (DUBs) * effector protein * host–pathogen interaction
OECD category: Biochemistry and molecular biology
Impact factor: 4.926, year: 2021
Method of publishing: Open access
https://doi.org/10.3390/microorganisms9030638
Permanent Link: http://hdl.handle.net/11104/0319088 - 7.0477103 - ÚOCHB 2018 RIV AT eng J - Journal Article
Hercík, Kamil - Brynda, Jiří - Nencka, Radim - Bouřa, Evžen
Structural basis of Zika virus methyltransferase inhibition by sinefungin.
Archives of Virology. Roč. 162, č. 7 (2017), s. 2091-2096. ISSN 0304-8608. E-ISSN 1432-8798
R&D Projects: GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : crystal structure * flavivirus RNA * NS5
OECD category: Virology
Impact factor: 2.160, year: 2017
Permanent Link: http://hdl.handle.net/11104/0273489 - 8.0474801 - ÚOCHB 2018 RIV NL eng J - Journal Article
Hercík, Kamil - Kozák, Jaroslav - Šála, Michal - Dejmek, Milan - Hřebabecký, Hubert - Zborníková, Eva - Smola, Miroslav - Růžek, Daniel - Nencka, Radim - Bouřa, Evžen
Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase.
Antiviral Research. Roč. 137, Jan (2017), s. 131-133. ISSN 0166-3542. E-ISSN 1872-9096
R&D Projects: GA ČR GA15-09310S
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : hepatitis C virus * borne encephalitis virus * crystal structure
OECD category: Organic chemistry
Impact factor: 4.307, year: 2017
Permanent Link: http://hdl.handle.net/11104/0271754