Search results
- 1.0584427 - FGÚ 2025 RIV GB eng J - Journal Article
Cheema, Marie Munawar - Kotrbová Macáková, Zuzana - Hrčka Krausová, Barbora - Adla, Santosh Kumar - Slavíková, Barbora - Chodounská, Hana - Kratochvíl, Miroslav - Vondrášek, Jiří - Sedlák, David - Balaštík, Martin - Kudová, Eva
5β-reduced neuroactive steroids as modulators of growth and viability of postnatal neurons and glia.
Journal of Steroid Biochemistry and Molecular Biology. Roč. 239, May (2024), č. článku 106464. ISSN 0960-0760
R&D Projects: GA MŠMT(CZ) LX22NPO5107; GA MZd(CZ) NV18-04-00085; GA ČR(CZ) GA21-24571S
Research Infrastructure: CZ-OPENSCREEN III - 90130; CZ-OPENSCREEN II - 90063; CCP II - 90126
Institutional support: RVO:67985823 ; RVO:61388963 ; RVO:68378050
Keywords : neurosteroids * neuroactive steroids * neurite growth * computational analysis * myelin basic protein * high-content screening
OECD category: Clinical neurology
Impact factor: 4.1, year: 2022
https://doi.org/10.1016/j.jsbmb.2024.106464
Permanent Link: https://hdl.handle.net/11104/0352546 - 2.0565955 - ÚOCHB 2023 RIV CH eng J - Journal Article
Tonduru, A. K. - Adla, Santosh Kumar - Huttunen, K. M. - Kronenberger, T. - Poso, A.
Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes.
Molecules. Roč. 27, č. 23 (2022), č. článku 8531. E-ISSN 1420-3049
R&D Projects: GA MŠMT(CZ) EF20_079/0017783
Institutional support: RVO:61388963
Keywords : organic anion transporting polypeptides (OATPs) * molecular dynamics simulations * homology models * xenobiotic transporters * Solute-Carrier O (SLCO)
OECD category: Organic chemistry
Impact factor: 4.6, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/molecules27238531
Permanent Link: https://hdl.handle.net/11104/0337423
Research data: Zenodo - 3.0565333 - ÚOCHB 2023 RIV NL eng J - Journal Article
Markowicz-Piasecka, M. - Darłak, P. - Markiewicz, A. - Sikora, J. - Adla, Santosh Kumar - Bagina, S. - Huttunen, K. M.
Current approaches to facilitate improved drug delivery to the central nervous system.
European Journal of Pharmaceutics and Biopharmaceutics. Roč. 181, December (2022), s. 249-262. ISSN 0939-6411. E-ISSN 1873-3441
Institutional support: RVO:61388963
Keywords : drug delivery system * blood–brain barrier (BBB) * central nervous system * brain-targeted therapy * nanotechnology
OECD category: Biochemistry and molecular biology
Impact factor: 4.9, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.ejpb.2022.11.003
Permanent Link: https://hdl.handle.net/11104/0336882 - 4.0558866 - ÚOCHB 2023 RIV CH eng J - Journal Article
Huttunen, J. - Adla, Santosh Kumar - Markowicz-Piasecka, M. - Huttunen, K. M.
Increased/Targeted Brain (Pro)Drug Delivery via Utilization of Solute Carriers (SLCs).
Pharmaceutics. Roč. 14, č. 6 (2022), č. článku 1234. E-ISSN 1999-4923
Institutional support: RVO:61388963
Keywords : blood-brain barrier (BBB) * brain drug delivery * prodrugs * solute carriers (SLCs)
OECD category: Biochemistry and molecular biology
Impact factor: 5.4, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/pharmaceutics14061234
Permanent Link: https://hdl.handle.net/11104/0332446 - 5.0557115 - ÚOCHB 2023 RIV US eng J - Journal Article
Markowicz-Piasecka, M. - Markiewicz, A. - Darlak, P. - Sikora, J. - Adla, Santosh Kumar - Bagina, S. - Huttunen, K. M.
Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics.
Neurotherapeutics. Roč. 19, č. 3 (2022), s. 942-976. ISSN 1933-7213. E-ISSN 1878-7479
Institutional support: RVO:61388963
Keywords : brain-blood barrier * prodrug approach * carrier-mediated transport * receptor-mediated transport * drug delivery
OECD category: Biochemistry and molecular biology
Impact factor: 5.7, year: 2022
Method of publishing: Limited access
https://doi.org/10.1007/s13311-022-01228-5
Permanent Link: http://hdl.handle.net/11104/0331172 - 6.0546196 - ÚOCHB 2022 RIV CH eng J - Journal Article
Adla, Santosh Kumar - Tonduru, A. K. - Kronenberger, T. - Kudová, Eva - Poso, A. - Huttunen, K. M.
Neurosteroids: Structure-Uptake Relationships and Computational Modeling of Organic Anion Transporting Polypeptides (OATP)1A2.
Molecules. Roč. 26, č. 18 (2021), č. článku 5662. E-ISSN 1420-3049
R&D Projects: GA MŠMT(CZ) EF20_079/0017783; GA MZd(CZ) EF16_025/0007444
Institutional support: RVO:61388963
Keywords : neurosteroid * cellular uptake * Organic Anion Transporting Polypeptides (OATPs) * docking * molecular modeling
OECD category: Organic chemistry
Impact factor: 4.927, year: 2021
Method of publishing: Open access
https://doi.org/10.3390/molecules26185662
Permanent Link: http://hdl.handle.net/11104/0322745 - 7.0544519 - ÚOCHB 2022 RIV CH eng J - Journal Article
Markowicz-Piasecka, M. - Huttunen, J. - Montaser, A. - Adla, Santosh Kumar - Auriola, S. - Lehtonen, M. - Huttunen, K. M.
Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP).
International Journal of Molecular Sciences. Roč. 22, č. 14 (2021), č. článku 7727. E-ISSN 1422-0067
R&D Projects: GA MŠMT(CZ) EF20_079/0017783
Institutional support: RVO:61388963
Keywords : breast cancer resistant protein (BCRP) * ganciclovir (GCV) * methotrexate (MTX) * MCF-7/MDA-MB-231 human breast cancer cells * multidrug resistance (MDR)
OECD category: Organic chemistry
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://doi.org/10.3390/ijms22147727
Permanent Link: http://hdl.handle.net/11104/0321357 - 8.0505510 - ÚOCHB 2020 RIV GB eng J - Journal Article
Šmídková, Markéta - Hájek, Miroslav - Adla, Santosh Kumar - Slavíková, Barbora - Chodounská, Hana - Matoušová, Marika - Mertlíková-Kaiserová, Helena - Kudová, Eva
Screening of novel 3 alpha 5 beta-neurosteroids for neuroprotective activity against glutamate- or NMDA-induced excitotoxicity.
Journal of Steroid Biochemistry and Molecular Biology. Roč. 189, May (2019), s. 195-203. ISSN 0960-0760
R&D Projects: GA TA ČR(CZ) TE01020028; GA MŠMT LO1302; GA TA ČR(CZ) TN01000013
Institutional support: RVO:61388963
Keywords : neurosteroids * NMDAR * glutamate excitotoxicity * neuroprotection
OECD category: Biochemistry and molecular biology
Impact factor: 3.813, year: 2019
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/abs/pii/S0960076019300378?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0296991 - 9.0498559 - ÚOCHB 2019 RIV CH eng J - Journal Article
Adla, Santosh Kumar - Slavíková, Barbora - Chodounská, Hana - Vyklický, Vojtěch - Ladislav, Marek - Hubálková, Pavla - Krausová, Barbora - Smejkalová, Tereza - Nekardová, Michaela - Šmídková, Markéta - Monincová, Lenka - Souček, Radko - Vyklický ml., Ladislav - Kudová, Eva
Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif.
Frontiers in Pharmacology. Roč. 9, Nov 12 (2018), č. článku 1299. ISSN 1663-9812. E-ISSN 1663-9812
R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GBP208/12/G016; GA ČR(CZ) GA17-02300S; GA ČR(CZ) GJ16-03913Y; GA MZd(CZ) NV15-29370A; GA MŠMT LO1302; GA MŠMT(CZ) ED1.1.00/02.0109
Grant - others:AV ČR(CZ) MSM200111601
Program: Program na podporu mezinárodní spolupráce začínajících výzkumných pracovníků
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : neurosteroid * amide * NMDA receptor * plasma stability * structure-activity relationship
OECD category: Biochemistry and molecular biology
Impact factor: 3.845, year: 2018
https://www.frontiersin.org/articles/10.3389/fphar.2018.01299/full
Permanent Link: http://hdl.handle.net/11104/0291127 - 10.0474432 - ÚOCHB 2018 RIV US eng J - Journal Article
Adla, Santosh Kumar - Slavíková, Barbora - Šmídková, Markéta - Tloušťová, Eva - Svoboda, Martin - Vyklický, Vojtěch - Krausová, Barbora - Hubálková, Pavla - Nekardová, Michaela - Holubová, Kristína - Valeš, Karel - Buděšínský, Miloš - Vyklický ml., Ladislav - Chodounská, Hana - Kudová, Eva
Physicochemical and biological properties of novel amide-based steroidal inhibitors of NMDA receptors.
Steroids. Roč. 117, Jan (2017), s. 52-61. ISSN 0039-128X. E-ISSN 1878-5867.
[Conference on Isoprenoids /23./. Minsk, 04.09.2016-07.09.2016]
R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GAP303/12/1464; GA MŠMT LO1302; GA MZd(CZ) NV15-29370A; GA ČR(CZ) GBP208/12/G016
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : neurosteroid * NMDA receptor * structure-activity relationship * amide * blood-brain-barrier permeability * Caco-2 assay
OECD category: Organic chemistry; Organic chemistry (FGU-C)
Impact factor: 2.523, year: 2017
Permanent Link: http://hdl.handle.net/11104/0271487