Search results
- 1.0545555 - ÚOCHB 2022 RIV FR eng J - Journal Article
Kalčic, Filip - Frydrych, Jan - Doleželová, Eva - Slapničková, Martina - Pachl, Petr - Poštová Slavětínská, Lenka - Dračínský, Martin - Hocková, Dana - Zíková, Alena - Janeba, Zlatko
C1′-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase.
European Journal of Medicinal Chemistry. Roč. 225, Dec 5 (2021), č. článku 113798. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) EF16_019/0000759; GA ČR(CZ) GA19-07707S
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : trypanosomiasis * purine salvage pathway * APRT * nucleotide analogues * phosphonates * enzyme inhibitors
OECD category: Organic chemistry; Microbiology (BC-A)
Impact factor: 7.088, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.ejmech.2021.113798
Permanent Link: http://hdl.handle.net/11104/0322237 - 2.0542010 - ÚOCHB 2022 RIV FR eng J - Journal Article
Frydrych, Jan - Keough, D. T. - Chavchich, M. - Travis, J. - Dračínský, Martin - Edstein, M. D. - Guddat, L. W. - Hocková, Dana - Janeba, Zlatko
Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity.
European Journal of Medicinal Chemistry. Roč. 219, Jul 5 (2021), č. článku 113416. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA19-07707S
Institutional support: RVO:61388963
Keywords : nucleoside phosphonates * phosphoroamidate prodrug * HG(X)PRT * hypoxanthine-guanine-(xanthine) phosphoribosyltransferase * Plasmodium falciparum * Plasmodium vivax
OECD category: Organic chemistry
Impact factor: 7.088, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.ejmech.2021.113416
Permanent Link: http://hdl.handle.net/11104/0319509 - 3.0532889 - ÚOCHB 2021 RIV CH eng J - Journal Article
Frydrych, Jan - Poštová Slavětínská, Lenka - Dračínský, Martin - Janeba, Zlatko
Efficient synthesis of α-branched purine-based acyclic nucleosides: Scopes and limitations of the method.
Molecules. Roč. 25, č. 18 (2020), č. článku 4307. E-ISSN 1420-3049
R&D Projects: GA MŠMT LTAUSA18086
Institutional support: RVO:61388963
Keywords : acyclonucleosides * hemiaminal ether * purine * multi-component reaction
OECD category: Organic chemistry
Impact factor: 4.412, year: 2020
Method of publishing: Open access
https://doi.org/10.3390/molecules25184307
Permanent Link: http://hdl.handle.net/11104/0311284 - 4.0489553 - ÚOCHB 2019 RIV DE eng J - Journal Article
Frydrych, Jan - Skácel, Jan - Šmídková, Markéta - Mertlíková-Kaiserová, Helena - Dračínský, Martin - Gnanasekaran, Ramachandran - Lepšík, Martin - Soto-Velasquez, M. - Watts, V. J. - Janeba, Zlatko
Synthesis of alpha-Branched Acyclic Nucleoside Phosphonates as Potential Inhibitors of Bacterial Adenylate Cyclases.
ChemMedChem. Roč. 13, č. 2 (2018), s. 199-206. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA MV VG20102015046; GA ČR(CZ) GBP208/12/G016; GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * adenylate cyclase toxin * bisamidates * Bordetella pertussis * prodrugs
OECD category: Organic chemistry
Impact factor: 3.016, year: 2018
Permanent Link: http://hdl.handle.net/11104/0283953