Search results
- 1.0518509 - ÚOCHB 2020 JP eng A - Abstract
Skácel, Jan - Keough, D. T. - Guddat, L. W. - Gutten, Ondrej - Hocková, Dana - Janeba, Zlatko
Design and Synthesis of Inhibitors of Enzymes of Purine Metabolism – Application of Direct Metalation of Heterocycles.
27th International Society of Heterocyclic Chemistry Congress. Kyoto: ISHC, 2019. s. 595.
[International Society of Heterocyclic Chemistry Congress /27./. 01.09.2019-06.09.2019, Kyoto]
R&D Projects: GA ČR(CZ) GA16-06049S; GA TA ČR(CZ) TN01000013
Institutional support: RVO:61388963
Keywords : enzyme inhibitior * purine * HG(X)PRT
OECD category: Organic chemistry
Permanent Link: http://hdl.handle.net/11104/0303922 - 2.0518499 - ÚOCHB 2020 TH eng A - Abstract
Břehová, Petra - Šmídková, Markéta - Skácel, Jan - Dračínský, Martin - Mertlíková-Kaiserová, Helena - Velasquez, M. P. S. - Watts, W. J. - Janeba, Zlatko
Synthesis of acyclic nucleoside phosphonates derived from 2-aminothiazoles and their evaluation as inhibitors of bacterial and human adenylate cyclases.
20th Tetrahedron Symposium. Bangkok: Elsevier, 2019. P1.005, „P1004“.
[Tetrahedron Symposium /20./. 18.06.2019-21.06.2019, Bangkok]
Institutional support: RVO:61388963
Keywords : nucleoside analogues * adenylate cyclases * aminothiazoles
OECD category: Organic chemistry
Permanent Link: http://hdl.handle.net/11104/0303890 - 3.0518498 - ÚOCHB 2020 TH eng A - Abstract
Česnek, Michal - Šafránek, Michal - Skácel, Jan - Dračínský, Martin - Mertlíková-Kaiserová, Helena - Velasquez, M. P. S. - Watts, W. J. - Janeba, Zlatko
Synthesis of 5-[2-(phosphonomethoxy)ethyl] (PME) derivatives of 4-substituted 2-aminothiazoles as potential inhibitors of bacterial and human adenylate cyclases.
20th Tetrahedron Symposium. Bangkok: Elsevier, 2019. P1.005, „P1005“.
[Tetrahedron Symposium /20./. 18.06.2019-21.06.2019, Bangkok]
Institutional support: RVO:61388963
Keywords : adenylate cyclases * aminothiazoles
OECD category: Organic chemistry
Permanent Link: http://hdl.handle.net/11104/0303886 - 4.0506263 - ÚOCHB 2020 CZ eng A - Abstract
Skácel, Jan - Baszczyňski, Ondřej - Mertlíková-Kaiserová, Helena - Tloušťová, Eva - Pachl, Petr - Maloy Řezáčová, Pavlína - Snášel, Jan - Pichová, Iva - Janeba, Zlatko
Development of purine nucleoside phosphorylase inhibitors as potential anticancer therapeutics.
Czech Chemical Society Symposium Series. Roč. 17, č. 1 (2019), s. 34. ISSN 2336-7202.
[Interdisciplinary Meeting of Young Researchers and Students in the Field of Chemistry, Biochemistry, Molecular Biology, and Biomaterials /19./. 20.05.2019-23.05.2019, Milovy]
R&D Projects: GA TA ČR(CZ) TN01000013
Institutional support: RVO:61388963
Keywords : PNP * anticancer therapeutics
OECD category: Organic chemistry
Permanent Link: http://hdl.handle.net/11104/0297752 - 5.0485126 - ÚOCHB 2018 DE eng A - Abstract
Skácel, Jan - Hocková, Dana - Janeba, Zlatko
Synthesis of tetra-Substituted Thiophenes via Direct Metalation.
26th ISHC Congress. Regensburg: International Society of Heterocyclic Chemistry, 2017. s. 358.
[ISHC Congress /26./. 03.09.2017-08.09.2017, Regensburg]
R&D Projects: GA ČR(CZ) GA16-06049S
Institutional support: RVO:61388963
Keywords : thiophenes * metalation * HG(X)PRT
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0280336 - 6.0481306 - ÚOCHB 2018 CZ eng A - Abstract
Skácel, Jan - Keough, D. T. - Guddat, L. W. - Janeba, Zlatko - Hocková, Dana
Design and synthesis of potential HG(X)PRT inhibitors based on polysubstituted thiophenes: Utilization of direct metalation of heterocycles.
SCNAC 2017. 17th Symposium on Chemistry of Nucleic Acid Components. Praha: Confis Conference, 2017. s. 205.
[SCNAC 2017. Symposium on Chemistry of Nucleic Acid Components /17./. 04.06.2017-09.06.2017, Český Krumlov]
R&D Projects: GA ČR(CZ) GA16-06049S
Institutional support: RVO:61388963
Keywords : nucleotide analogues * enzyme inhibitors * heterocycles
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0276889 - 7.0481189 - ÚOCHB 2018 CZ eng A - Abstract
Břehová, Petra - Šmídková, Markéta - Skácel, Jan - Dračínský, Martin - Mertlíková-Kaiserová, Helena - Velasquez, M. P. S. - Watts, V. J. - Janeba, Zlatko
Synthesis of acyclic nucleoside phosphonates with unnatural heterocyclic bases bearing aryl substituents and their inhibitory activity towards bacterial and human adenylate cyclases.
SCNAC 2017. 17th Symposium on Chemistry of Nucleic Acid Components. Praha: Confis Conference, 2017. s. 125.
[SCNAC 2017. Symposium on Chemistry of Nucleic Acid Components /17./. 04.06.2017-09.06.2017, Český Krumlov]
R&D Projects: GA MV VG20102015046
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates (ANPs) * adenylate cyclase toxin (ACT) * Bordetella pertussis
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0276789 - 8.0464963 - ÚOCHB 2017 ES eng A - Abstract
Břehová, Petra - Šmídková, Markéta - Mertlíková-Kaiserová, Helena - Skácel, Jan - Dračínský, Martin - Janeba, Zlatko
Synthesis of acyclic nucleoside phosphonates bearing aryl substituent at the acyclic linker as potential inhibitors of adenylate cyclase toxin from Bordetella pertussis.
17th Tetrahedron Symposium. Challenges in Biological, Bioorganic, Organic and Medicinal Chemistry. Sitges: Elsevier, 2016.
[Tetrahedron Symposium. Challenges in Biological, Bioorganic, Organic and Medicinal Chemistry /17./. 28.06.2016-01.07.2016, Sitges]
R&D Projects: GA MV VG20102015046
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates (ANPs) * adenylate cyclase toxin (ACT) * Bordetella pertussis
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0263697