Search results
- 1.0580493 - BC 2024 RIV CH eng J - Journal Article
Martins, Larissa Almeida - Buša, Michal - Chlastáková, A. - Kotál, Jan - Beránková, Z. - Stergiou, N. - Jmel, Mohamed Amine - Schmitt, E. - Chmelař, J. - Mareš, Michael - Kotsyfakis, Michalis
Protease-bound structure of Ricistatin provides insights into the mechanism of action of tick salivary cystatins in the vertebrate host.
Cellular and Molecular Life Sciences. Roč. 80, č. 11 (2023), č. článku 339. ISSN 1420-682X. E-ISSN 1420-9071
R&D Projects: GA ČR(CZ) GA19-07247S; GA MŠMT(CZ) EF16_019/0000759; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LTAUSA19109
Institutional support: RVO:60077344 ; RVO:61388963
Keywords : ray crystal-structure * sialostatin-l * functional expression * cysteine cathepsins * mammalian legumain * ixodes-scapularis * inhibitors * stefin * generation * peptidase * Ixodes ricinus * Tick saliva * Cystatins * Protease inhibition * Protein structure * Host-parasite interactions
OECD category: Biochemistry and molecular biology; Biochemistry and molecular biology (UOCHB-X)
Impact factor: 8, year: 2022
Method of publishing: Limited access
https://link.springer.com/article/10.1007/s00018-023-04993-4
Permanent Link: https://hdl.handle.net/11104/0349268 - 2.0572377 - BC 2024 RIV GB eng J - Journal Article
Kascaková, B. - Kotál, Jan - Havlíčková, P. - Vopatková, V. - Prudnikova, T. - Grinkevich, P. - Kutý, M. - Chmelař, J. - Smatanová, I.K.
Conformational transition of the Ixodes ricinus salivary serpin Iripin-4.
Acta Crystallographica Section D-Structural Biology. Roč. 79, MAY (2023), s. 409-419. ISSN 2059-7983. E-ISSN 2059-7983
Institutional support: RVO:60077344
Keywords : serpins * Iripin-4 * X-ray structure * native conformation * cleaved conformation * Ixodes ricinus
OECD category: Microbiology
Impact factor: 2.2, year: 2022
Method of publishing: Open access
https://scripts.iucr.org/cgi-bin/paper?S2059798323002322
Permanent Link: https://hdl.handle.net/11104/0345554 - 3.0560486 - BC 2023 RIV CH eng J - Journal Article
Medina, J.M. - Jmel, Mohamed Amine - Cuveele, Brent - Gomez-Martin, C. - Aparicio-Puerta, E. - Mekki, Imen - Kotál, Jan - Martins, Larissa Almeida - Hackenberg, M. - Bensaoud, Chaima - Kotsyfakis, Michalis
Transcriptomic analysis of the tick midgut and salivary gland responses upon repeated blood-feeding on a vertebrate host.
Frontiers in Cellular and Infection Microbiology. Roč. 12, AUG (2022), č. článku 919786. ISSN 2235-2988. E-ISSN 2235-2988
R&D Projects: GA ČR(CZ) GA19-07247S; GA MŠMT(CZ) EF16_019/0000759; GA MŠMT(CZ) EF20_079/0017809
Institutional support: RVO:60077344
Keywords : ticks * salivary glands * midgut * repeated exposure * transcriptome
OECD category: Biochemistry and molecular biology
Impact factor: 5.7, year: 2022
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fcimb.2022.919786/full
Permanent Link: https://hdl.handle.net/11104/0340083 - 4.0554304 - BC 2022 RIV GB eng J - Journal Article
Martins, Larissa Almeida - Bensaoud, Chaima - Kotál, Jan - Chmelař, J. - Kotsyfakis, Michalis
Tick salivary gland transcriptomics and proteomics.
Parasite immunology. Roč. 43, č. 5 (2021), č. článku e12807. ISSN 0141-9838. E-ISSN 1365-3024
R&D Projects: GA ČR(CZ) GA19-07247S; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344
Keywords : serine proteinase-inhibitors * histamine-binding proteins * rna * sialome * insight * vector * acari * sialotranscriptome * identification * micrornas * proteome * salivary gland * sialome * tick * transcriptome
OECD category: Biochemistry and molecular biology
Impact factor: 2.206, year: 2021
Method of publishing: Limited access
https://onlinelibrary.wiley.com/doi/10.1111/pim.12807
Permanent Link: http://hdl.handle.net/11104/0328938 - 5.0554204 - BC 2022 RIV CH eng J - Journal Article
Kotál, Jan - Polderdijk, S. - Langhansová, H. - Ederova, M. - Martins, Larissa Almeida - Beránková, Z. - Chlastáková, A. - Hajdušek, Ondřej - Kotsyfakis, Michalis - Huntington, J. - Chmelař, J.
Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement.
International Journal of Molecular Sciences. Roč. 22, č. 17 (2021), č. článku 9480. E-ISSN 1422-0067
R&D Projects: GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344
Keywords : tsetse thrombin inhibitor * tick saliva * anticoagulant activity * blood-coagulation * immune-response * protein * disease * expression * peptide * cloning * blood coagulation * crystal structure * Ixodes ricinus * parasite * saliva * serpin * tick
OECD category: Microbiology
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1422-0067/22/17/9480
Permanent Link: http://hdl.handle.net/11104/0328823 - 6.0554123 - BC 2022 RIV GB eng J - Journal Article
Kaščáková, B. - Kotál, Jan - Martins, Larissa Almeida - Beránková, Z. - Langhansová, H. - Calvo, E. - Crossley, J. - Havlíčková, P. - Dyčka, F. - Prudníková, T. - Kutý, M. - Kotsyfakis, Michalis - Chmelař, J. - Smatanová, I.
Structural and biochemical characterization of the novel serpin Iripin-5 from Ixodes ricinus.
Acta Crystallographica Section D-Structural Biology. Roč. 77, SEP 1 2021 (2021), s. 1183-1196. ISSN 2059-7983. E-ISSN 2059-7983
Institutional support: RVO:60077344
Keywords : tick salivary protein * molecular simulations * crystal-structure * inhibitors * mechanism * crystallography * interface * ovalbumin * immunity * features * serpins * serine protease inhibitors * Iripin-5 * X-ray structure * Ixodes ricinus * tick saliva
OECD category: Biochemistry and molecular biology
Impact factor: 5.699, year: 2021
Method of publishing: Limited access
https://scripts.iucr.org/cgi-bin/paper?S2059798321007920
Permanent Link: http://hdl.handle.net/11104/0328758 - 7.0554108 - BC 2022 RIV CH eng J - Journal Article
Chlastáková, A. - Kotál, Jan - Beránková, Z. - Kaščáková, B. - Martins, Larissa Almeida - Langhansová, H. - Prudníková, T. - Ederova, M. - Kutá Smatanová, I. - Kotsyfakis, Michalis - Chmelař, J.
Iripin-3, a New Salivary Protein Isolated From Ixodes ricinus Ticks, Displays Immunomodulatory and Anti-Hemostatic Properties In Vitro.
Frontiers in Immunology. Roč. 12, MAR 1 2021 (2021), č. článku 626200. ISSN 1664-3224. E-ISSN 1664-3224
R&D Projects: GA ČR(CZ) GA19-07247S
Institutional support: RVO:60077344
Keywords : antithrombin-iii * factor-viia * inhibitors * serpins * infestations * family * glycosylation * annotation * expression * interface * tick * serpin * X-ray crystallography * blood coagulation * inflammation * adaptive immunity * Ixodes ricinus * saliva
OECD category: Biochemistry and molecular biology
Impact factor: 8.787, year: 2021
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fimmu.2021.626200/full
Permanent Link: http://hdl.handle.net/11104/0328746 - 8.0550906 - BC 2022 RIV CH eng J - Journal Article
Kotál, Jan - Buša, Michal - Urbanová, Veronika - Řezáčová, Pavlína - Chmelař, J. - Langhansová, H. - Sojka, Daniel - Mareš, Michael - Kotsyfakis, Michalis
Mialostatin, a Novel Midgut Cystatin from Ixodes ricinus Ticks: Crystal Structure and Regulation of Host Blood Digestion.
International Journal of Molecular Sciences. Roč. 22, č. 10 (2021), č. článku 5371. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA19-07247S; GA ČR(CZ) GA21-08826S; GA MŠMT(CZ) EF16_019/0000759; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:60077344 ; RVO:61388963
Keywords : rhipicephalus boophilus microplus * hard tick * functional-characterization * ornithodoros-moubata * protease inhibitors * proteolytic-enzymes * salivary cystatin * egg-white * expression * gut * cathepsin * crystal structure * cysteine protease * digestion * Ixodes ricinus * midgut * parasite
OECD category: Microbiology; Biochemistry and molecular biology (UOCHB-X)
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1422-0067/22/10/5371
Permanent Link: http://hdl.handle.net/11104/0326208 - 9.0538674 - BC 2021 RIV NL eng J - Journal Article
Martins, Larissa Almeida - Kotál, Jan - Bensaoud, Chaima - Chmelař, J. - Kotsyfakis, Michalis
Small protease inhibitors in tick saliva and salivary glands and their role in tick-host-pathogen interactions.
Biochimica Et Biophysica Acta-Proteins and Proteomics. Roč. 1868, č. 2 (2020), č. článku 140336. ISSN 1570-9639. E-ISSN 1878-1454
R&D Projects: GA ČR(CZ) GA19-07247S; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344
Keywords : factor pathway inhibitor * kunitz-type inhibitor * ixodes-scapularis * soft tick * functional-characterization * transcriptome analysis * factor-xa * haemaphysalis-longicornis * differential expression * ornithodoros-moubata * Cystatins * Kunitz-domain proteins * Protease inhibitor * Saliva * Salivary gland * Sialomes * Tick-host-pathogen
OECD category: Biochemistry and molecular biology
Impact factor: 3.036, year: 2020
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S1570963919302213?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0316428 - 10.0519639 - BC 2020 RIV CH eng J - Journal Article
Kotál, Jan - Stergiou, N. - Buša, Michal - Chlastáková, A. - Beránková, Z. - Řezáčová, Pavlína - Langhansová, H. - Schwarz, Alexandra - Calvo, E. - Kopecký, J. - Mareš, Michael - Schmitt, E. - Chmelař, J. - Kotsyfakis, Michalis
The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin.
Cellular and Molecular Life Sciences. Roč. 76, č. 10 (2019), s. 2003-2013. ISSN 1420-682X. E-ISSN 1420-9071
R&D Projects: GA ČR(CZ) GA19-07247S; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344 ; RVO:61388963
Keywords : cd4(+) t-cells * sialostatin-l * nitric-oxide * schistosoma-japonicum * ixodes-scapularis * protein * inhibitor * responses * expression * mosquito * Cathepsin * Crystal structure * Immune responses * Ixodes ricinus * Saliva
OECD category: Biochemistry and molecular biology; Biochemistry and molecular biology (UOCHB-X)
Impact factor: 6.496, year: 2019
Method of publishing: Limited access
https://link.springer.com/article/10.1007%2Fs00018-019-03034-3
Permanent Link: http://hdl.handle.net/11104/0304643