Search results
- 1.0586002 - ÚOCHB 2025 RIV US eng J - Journal Article
Spiwoková, Petra - Horn, Martin - Fanfrlík, Jindřich - Jílková, Adéla - Fajtová, Pavla - Leontovyč, Adrian - Houštecká, Radka - Bieliková, Lucia - Brynda, Jiří - Chanová, M. - Mertlíková-Kaiserová, Helena - Diaz-Caro, E. J. E. - Almaliti, J. - El Sakkary, N. - Gerwick, W. H. - Caffrey, C. R. - Mareš, Michael
Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis.
ACS Infectious Diseases. Roč. 10, č. 6 (2024), s. 1935-1948. ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) LTAUSA19109; GA MŠMT(CZ) LUAUS23050; GA MZd(CZ) NV18-05-00345
Institutional support: RVO:61388963
Keywords : cathepsin B * cysteine protease * drug target * parasite * Schistosoma mansoni * acrylamide inhibitor
Impact factor: 5.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acsinfecdis.3c00589
Permanent Link: https://hdl.handle.net/11104/0353623 - 2.0522693 - ÚOCHB 2021 RIV US eng J - Journal Article
Houštecká, Radka - Hadzima, Martin - Fanfrlík, Jindřich - Brynda, Jiří - Pallová, Lenka - Hánová, Iva - Mertlíková-Kaiserová, Helena - Lepšík, Martin - Horn, Martin - Smrčina, M. - Majer, Pavel - Mareš, Michael
Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure–Activity Relationship and Binding Mode Analysis.
Journal of Medicinal Chemistry. Roč. 63, č. 4 (2020), s. 1576-1596. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA ČR GA15-18929S; GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : inhibitor * macrocycle * protease
OECD category: Biochemistry and molecular biology
Impact factor: 7.446, year: 2020
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01351
Permanent Link: http://hdl.handle.net/11104/0307144 - 3.0500423 - ÚOCHB 2019 RIV CZ cze J - Journal Article
Houštecká, Radka
Aspartátové proteasy a jejich funkce u parazitů.
[Aspartic proteases and their function in parasites.]
Bioprospect. Roč. 28, č. 4 (2018), s. 89-94. ISSN 1210-1737
R&D Projects: GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : parasites * proteolytic enzymes * aspartic proteases * protease inhibitors
OECD category: Biochemistry and molecular biology
Permanent Link: http://hdl.handle.net/11104/0292503 - 4.0489934 - ÚOCHB 2019 RIV US eng J - Journal Article
Hánová, Iva - Brynda, Jiří - Houštecká, Radka - Alam, N. - Sojka, Daniel - Kopáček, Petr - Marešová, Lucie - Vondrášek, Jiří - Horn, Martin - Schueler-Furman, O. - Mareš, Michael
Novel Structural Mechanism of Allosteric Regulation of Aspartic Peptidases via an Evolutionarily Conserved Exosite.
Cell Chemical Biology. Roč. 25, č. 3 (2018), s. 318-329. ISSN 2451-9448. E-ISSN 2451-9448
R&D Projects: GA ČR GA15-18929S; GA ČR GA13-11043S; GA MŠMT LO1302; GA ČR GA14-33693S
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : cathepsin D * activation intermediate * crystal structure
OECD category: Biochemistry and molecular biology
Impact factor: 6.762, year: 2018
https://www.sciencedirect.com/science/article/pii/S2451945618300011?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0284232