Search results
- 1.0548469 - ÚOCHB 2022 CZ eng A - Abstract
Hadzima, Martin - Houštecká, Radka - Pallová, Lenka - Hánová, Iva - Fanfrlík, Jindřich - Brynda, Jiří - Lepšík, Martin - Mertlíková-Kaiserová, Helena - Horn, Martin - Mareš, Michael - Majer, Pavel
Design, Synthesis and Activity of Biomimetic Macrocyclic Inhibitors of Human Cathepsin D.
Liblice 2021. 55th Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2021. s. 112.
[Liblice 2021. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /55./. 03.11.2021-06.11.2021, Špindlerův Mlýn]
Institutional support: RVO:61388963
Keywords : inhibitor * cathepsin * macrocycles * peptides * statine * synthesis
OECD category: Medicinal chemistry
Permanent Link: http://hdl.handle.net/11104/0324491 - 2.0521200 - ÚOCHB 2020 US eng A - Abstract
Hadzima, Martin - Houštecká, Radka - Pallová, Lenka - Fanfrlík, Jindřich - Brynda, Jiří - Lepšík, Martin - Horn, Martin - Mareš, Michael - Majer, Pavel
Design, Synthesis and Activity of Biomimetic Macrocyclic Inhibitors of Human Cathepsin D.
Boulder Peptide Symposium 2019. Boulder: Boulder Peptide Society, 2019.
[Boulder Peptide Symposium 2019. 23.09.2019-26.09.2019, Boulder]
Institutional support: RVO:61388963
Keywords : inhibitor * cathepsin * macrocycles * peptides * statine * synthesis
OECD category: Medicinal chemistry
Permanent Link: http://hdl.handle.net/11104/0305838 - 3.0521191 - ÚOCHB 2020 GR eng A - Abstract
Hadzima, Martin - Houštecká, Radka - Pallová, Lenka - Fanfrlík, Jindřich - Brynda, Jiří - Lepšík, Martin - Horn, Martin - Mareš, Michael - Majer, Pavel
Design, Synthesis and Activity of Biomimetic Macrocyclic Inhibitors of Human Cathepsin D.
EFMC-ASMC’19. 8th EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry. Athens: European Federation for Medicinal Chemistry, 2019. s. 187.
[EFMC-ASMC’19. EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry /8./. 01.09.2019-05.09.2019, Athens]
Institutional support: RVO:61388963
Keywords : inhibitor * cathepsin * macrocycles * peptides * statine * synthesis
OECD category: Medicinal chemistry
Permanent Link: http://hdl.handle.net/11104/0305833 - 4.0491272 - ÚOCHB 2019 CZ eng A - Abstract
Hánová, Iva - Brynda, Jiří - Hobizalová, Radka - Alam, N. - Sojka, Daniel - Kopáček, Petr - Marešová, Lucie - Vondrášek, Jiří - Horn, Martin - Schueler-Furman, O. - Mareš, Michael
Novel structural mechanism of allosteric regulation of aspartic peptidases via evolutionary conserved exosite.
Prague Protein Spring Meeting 2018: Proteins at Work. Praha: Ústav organické chemie a biochemie AV ČR, 2018 - (Votrubová, T.; Pergl Šustková, H.; Vondrášek, J.). s. 66. ISBN 978-80-86241-58-6.
[Prague Protein Spring Meeting 2018: Proteins at Work. 03.05.2018-06.05.2018, Praha]
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : aspartic peptidase * IrCD1 * exosite
OECD category: Biochemistry and molecular biology
Permanent Link: http://hdl.handle.net/11104/0285576 - 5.0487070 - ÚOCHB 2018 CA eng A - Abstract
Hobizalová, Radka - Palová, Lenka - Fanfrlík, Jindřich - Brynda, Jiří - Monincová, Lenka - Lepšík, Martin - Horn, Martin - Majer, Pavel - Mareš, Michael
Novel macrocyclic inhibitors of human cathepsin D.
IPS 2017. 10th General Meeting of the International Proteolysis Society. Banff: International Proteolysis Society, 2017. s. 150.
[IPS 2017. General Meeting of the International Proteolysis Society /10./. 28.10.2017-02.11.2017, Banff]
R&D Projects: GA ČR GA15-18929S; GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : human cathepsin D * inhibitors
Subject RIV: CE - Biochemistry
Permanent Link: http://hdl.handle.net/11104/0281750 - 6.0487063 - ÚOCHB 2018 CA eng A - Abstract
Hánová, Iva - Brynda, Jiří - Hobizalová, Radka - Alam, N. - Sojka, Daniel - Kopáček, Petr - Marešová, Lucie - Vondrášek, Jiří - Horn, Martin - Schueler-Furman, O. - Mareš, Michael
Novel structural mechanism of allosteric regulation of aspartic peptidases via evolutionary conserved exosite.
IPS 2017. 10th General Meeting of the International Proteolysis Society. Banff: International Proteolysis Society, 2017. s. 58.
[IPS 2017. General Meeting of the International Proteolysis Society /10./. 28.10.2017-02.11.2017, Banff]
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : aspartic peptidases * allosteric regulation
Subject RIV: CE - Biochemistry
Permanent Link: http://hdl.handle.net/11104/0281744 - 7.0480712 - ÚOCHB 2018 GB eng A - Abstract
Hánová, Iva - Brynda, Jiří - Hobizalová, Radka - Alam, N. - Sojka, Daniel - Kopáček, Petr - Marešová, Lucie - Vondrášek, Jiří - Horn, Martin - Schueler-Furman, O. - Mareš, Michael
Novel structural mechanism of allosteric regulation of aspartic peptidases via evolutionary conserved exosite.
FEBS Journal. Roč. 284, Suppl 1 (2017), s. 300-301. ISSN 1742-464X. E-ISSN 1742-4658.
[FEBS Congress /42./ From Molecules to Cells and Back. 10.09.2017-14.09.2017, Jerusalem]
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : aspartic peptidases * exosite inhibition
Subject RIV: CE - Biochemistry
Permanent Link: http://hdl.handle.net/11104/0276419 - 8.0471335 - ÚOCHB 2017 IT eng A - Abstract
Hánová, Iva - Brynda, Jiří - Hobizalová, Radka - Alam, N. - Sojka, Daniel - Kopáček, Petr - Horn, Martin - Schueler-Furman, O. - Mareš, Michael
Structural mechanism of regulation of aspartic proteases through a propeptide-binding exosite: a lesson from blood feeding parasites.
Gordon Research Conference on Proteolytic Enzymes & Their Inhibitors. Barga: GRC, 2016.
[Gordon Research Conference on Proteolytic Enzymes & Their Inhibitors. 26.06.2016-01.07.2016, Barga]
R&D Projects: GA ČR GA15-18929S; GA ČR GA13-11043S; GA MŠMT LO1302
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : cathepsin D * exosite * inhibitor
Subject RIV: CE - Biochemistry
Permanent Link: http://hdl.handle.net/11104/0268799 - 9.0471239 - ÚOCHB 2017 CZ eng A - Abstract
Monincová, Lenka - Pallová, Lenka - Hobizalová, Radka - Mareš, Michael - Majer, Pavel
Design, synthesis and activity of novel macrocyclic inhibitors of human cathepsin D.
Liblice 2016. 51st Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2016. s. 114.
[Liblice 2016. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /51./. 11.11.2016-13.11.2016, Lázně Bělohrad]
Institutional support: RVO:61388963
Keywords : cathepsin D * macrocyclic inhibitors
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0268789 - 10.0459968 - ÚOCHB 2017 CZ eng A - Abstract
Hánová, Iva - Brynda, Jiří - Hobizalová, Radka - Alam, N. - Sojka, Daniel - Kopáček, Petr - Marešová, Lucie - Vondrášek, Jiří - Horn, Martin - Schueler-Furman, O. - Mareš, Michael
Structural mechanism of regulation of aspartic proteases through a propeptide-binding exosite: a lesson from blood-feeding parasites.
Prague Protein Spring Meeting 2016: Proteins and their Design. Praha: Ústav organické chemie a biochemie AV ČR, 2016. s. 71. ISBN 978-80-86241-55-5.
[Prague Protein Spring Meeting 2016: Proteins and their Design /4./. 05.05.2016-08.05.2016, Praha]
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : cathepsin D * aspartic proteases
Subject RIV: CE - Biochemistry
Permanent Link: http://hdl.handle.net/11104/0260115