Search results
- 1.0534661 - ÚACH 2021 RIV DE eng J - Journal Article
Nekvinda, Jan - Kugler, Michael - Holub, Josef - El Anwar, Suzan - Brynda, Jiří - Pospíšilová, K. - Růžičková, Z. - Řezáčová, Pavlína - Grüner, Bohumír
Direct Introduction of an Alkylsulfonamido Group on C-sites of Isomeric Dicarba-closo-dodecaboranes: The Influence of Stereochemistry on Inhibitory Activity against the Cancer-Associated Carbonic Anhydrase IX Isoenzyme.
Chemistry - A European Journal. Roč. 26, č. 69 (2020), s. 16541-16553. ISSN 0947-6539. E-ISSN 1521-3765
R&D Projects: GA ČR(CZ) GA18-27648S; GA ČR(CZ) GA15-05677S
Grant - others:AV ČR(CZ) L200321851
Program: Program podpory perspektivníchlidských zdrojů - postdoktorandů
Institutional support: RVO:61388980 ; RVO:68378050
Keywords : medicinal chemistry * indomethacin * carbonic anhydrase * dicarba-closo-dodecaboranes * inhibitors * sulfonamide
OECD category: Inorganic and nuclear chemistry; Biochemistry and molecular biology (UMG-J)
Impact factor: 5.236, year: 2020
Method of publishing: Open access with time embargo
Permanent Link: http://hdl.handle.net/11104/0314883File Download Size Commentary Version Access Direct.pdf 2 1.8 MB Author’s postprint open-access Direct SI.pdf 0 5.2 MB Author’s postprint open-access - 2.0531266 - ÚMG 2021 RIV FR eng J - Journal Article
Dvořanová, J. - Kugler, Michael - Holub, J. - Šícha, V. - Das, V. - Nekvinda, J. - El Anwar, S. - Havránek, M. - Pospíšilová, K. - Fábry, Milan - Král, Vlastimil - Medvědiková, M. - Matějková, S. - Lišková, B. - Gurská, S. - Dzubak, P. - Brynda, Jiří - Hajduch, M. - Gruner, B. - Řezáčová, P.
Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX.
European Journal of Medicinal Chemistry. Roč. 200, August (2020), č. článku 112460. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA15-05677S
Institutional support: RVO:68378050
Keywords : Anti-tumor agents * Carbonic anhydrase IX * Carboranes * Dicarbollide * Enzyme inhibitors * Drug penetration * Multicellular spheroids
OECD category: Medicinal chemistry
Impact factor: 6.514, year: 2020
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/abs/pii/S0223523420304311?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0309958 - 3.0524603 - ÚOCHB 2021 RIV FR eng J - Journal Article
Dvořanová, J. - Kugler, Michael - Holub, Josef - Šícha, Václav - Das, V. - Nekvinda, Jan - El Anwar, Suzan - Havránek, M. - Pospíšilová, Klára - Fábry, M. - Král, V. - Medvedíková, M. - Matějková, Stanislava - Lišková, B. - Gurská, S. - Džubák, P. - Brynda, J. - Hajdúch, M. - Grüner, Bohumír - Řezáčová, Pavlína
Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX.
European Journal of Medicinal Chemistry. Roč. 200, Aug 15 (2020), č. článku 112460. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA18-27648S; GA ČR(CZ) GA15-05677S; GA TA ČR(CZ) TE01020028; GA MŠMT(CZ) LM2015064
Grant - others:AV ČR(CZ) L200321851
Program: Program podpory perspektivníchlidských zdrojů - postdoktorandů
Institutional support: RVO:61388963 ; RVO:61388980
Keywords : anti-tumor agents * carbonic anhydrase IX * carboranes * dicarbollide * enzyme inhibitors * drug penetration * multicellular spheroids
OECD category: Biochemistry and molecular biology; Inorganic and nuclear chemistry (UACH-T)
Impact factor: 6.514, year: 2020
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0223523420304311?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0308946 - 4.0511473 - ÚACH 2020 RIV US eng J - Journal Article
Grüner, Bohumír - Brynda, Jiří - Das, V. - Šícha, Václav - Štěpánková, J. - Nekvinda, Jan - Holub, Josef - Pospíšilová, B. - Fábry, Milan - Pachl, P. - Král, Vlastimil - Kugler, M. - Mašek, V. - Medvědiková, M. - Matějková, S. - Nová, A. - Lišková, B. - Gurská, S. - Džubák, P. - Hajdúch, M. - Řezáčová, Pavlína
Metallacarborane sulfamides: Unconventional, specific, and highly selective inhibitors of carbonic anhydrase IX.
Journal of Medicinal Chemistry. Roč. 62, č. 21 (2019), s. 9560-9575. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR(CZ) GA15-05677S; GA ČR(CZ) GA18-27648S
Institutional support: RVO:61388980 ; RVO:68378050
Keywords : Anti-tumor agents * Carbonic anhydrase IX * Cobaltacarborane inhibitors * Drug penetration * Multicellular spheroids
OECD category: Inorganic and nuclear chemistry; Medicinal chemistry (UMG-J)
Impact factor: 6.205, year: 2019
Method of publishing: Limited access
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.9b00945
Permanent Link: http://hdl.handle.net/11104/0302697 - 5.0505253 - ÚMG 2020 RIV GB eng J - Journal Article
Srb, P. - Svoboda, M. - Benda, L. - Lepšík, M. - Tarabek, J. - Šícha, V. - Gruener, B. - Grantz-Saskova, K. - Brynda, Jiří - Řezáčová, Pavlína - Konvalinka, J. - Veverka, V.
Capturing a dynamically interacting inhibitor by paramagnetic NMR spectroscopy.
Physical Chemistry Chemical Physics. Roč. 21, č. 10 (2019), s. 5661-5673. ISSN 1463-9076. E-ISSN 1463-9084
R&D Projects: GA ČR(CZ) GA15-05677S
Institutional support: RVO:68378050
Keywords : hiv-1 protease * pseudocontact shifts * proteins * assignment * exchange * restraints * complexes * molecule
OECD category: Biophysics
Impact factor: 3.430, year: 2019
Method of publishing: Limited access
https://pubs.rsc.org/en/content/articlelanding/2019/CP/C9CP00416E#!divAbstract
Permanent Link: http://hdl.handle.net/11104/0297062 - 6.0503801 - ÚOCHB 2020 RIV GB eng J - Journal Article
Srb, Pavel - Svoboda, Michal - Benda, L. - Lepšík, Martin - Tarábek, Ján - Šícha, Václav - Grüner, Bohumír - Grantz Šašková, Klára - Brynda, Jiří - Řezáčová, Pavlína - Konvalinka, Jan - Veverka, Václav
Capturing a dynamically interacting inhibitor by paramagnetic NMR spectroscopy.
Physical Chemistry Chemical Physics. Roč. 21, č. 10 (2019), s. 5661-5673. ISSN 1463-9076. E-ISSN 1463-9084
R&D Projects: GA MŠMT(CZ) LO1304; GA MŠMT(CZ) LK11205; GA ČR(CZ) GA15-05677S; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963 ; RVO:61388980
Keywords : HIV-1 protease * pseudocontact shifts * proteins
OECD category: Biochemistry and molecular biology; Inorganic and nuclear chemistry (UACH-T)
Impact factor: 3.430, year: 2019
Method of publishing: Limited access
https://pubs.rsc.org/en/content/articlelanding/2019/CP/C9CP00416E#!divAbstract
Permanent Link: http://hdl.handle.net/11104/0296717 - 7.0491223 - ÚMG 2019 RIV GB eng J - Journal Article
Škerlová, Jana - Bláha, J. - Pachl, Petr - Hofbauerová, Kateřina - Kukačka, Zdeněk - Man, Petr - Pompach, Petr - Novák, Petr - Otwinowski, Z. - Brynda, Jiří - Vaněk, O. - Řezáčová, Pavlína
Crystal structure of native beta-N-acetylhexosaminidase isolated from Aspergillus oryzae sheds light onto its substrate specificity, high stability, and regulation by propeptide.
FEBS Journal. Roč. 285, č. 3 (2018), s. 580-598. ISSN 1742-464X. E-ISSN 1742-4658
R&D Projects: GA MŠMT(CZ) ED1.1.00/02.0109; GA MŠMT(CZ) LO1304; GA MŠMT(CZ) LO1509; GA MŠMT(CZ) LQ1604; GA MŠMT LG14009; GA MŠMT(CZ) LH15010; GA MŠMT(CZ) LM2015043; GA MŠMT(CZ) LD15089; GA ČR(CZ) GA15-05677S; GA ČR(CZ) GA16-24309S; GA ČR(CZ) GA15-15181S
Institutional support: RVO:68378050 ; RVO:61388971
Keywords : active pocket * carbohydrate biotechnology * glycosylation * mass spectrometry * propeptide * X-ray crystallography
OECD category: Biochemistry and molecular biology; Biochemistry and molecular biology (MBU-M)
Impact factor: 4.739, year: 2018
Permanent Link: http://hdl.handle.net/11104/0285263 - 8.0475948 - ÚOCHB 2018 RIV GB eng J - Journal Article
Eyrilmez, Saltuk M. - Bernhardt, E. - Dávalos, J. Z. - Lepšík, Martin - Hobza, Pavel - Assaf, K. I. - Nau, W. M. - Holub, Josef - Oliva-Enrich, J. M. - Fanfrlík, Jindřich - Hnyk, Drahomír
Binary twinned-icosahedral [B21H18](-) interacts with cyclodextrins as a precedent for its complexation with other organic motifs.
Physical Chemistry Chemical Physics. Roč. 19, č. 19 (2017), s. 11748-11752. ISSN 1463-9076. E-ISSN 1463-9084
R&D Projects: GA ČR(CZ) GBP208/12/G016; GA ČR(CZ) GA15-05677S
Institutional support: RVO:61388963 ; RVO:61388980
Keywords : host-guest chemistry * gas-phase basicities * mass spectrometry
OECD category: Physical chemistry; Inorganic and nuclear chemistry (UACH-T)
Impact factor: 3.906, year: 2017
http://pubs.rsc.org/en/content/articlehtml/2017/cp/c7cp01074e
Permanent Link: http://hdl.handle.net/11104/0272535 - 9.0471052 - ÚOCHB 2017 RIV GB eng J - Journal Article
Fanfrlík, Jindřich - Hnyk, Drahomír
Chalcogens act as inner and outer heteroatoms in borane cages with possible consequences for sigma-hole interactions.
CrystEngComm. Roč. 18, č. 47 (2016), s. 8982-8987. ISSN 1466-8033
R&D Projects: GA ČR(CZ) GBP208/12/G016; GA ČR(CZ) GA15-05677S
Institutional support: RVO:61388963 ; RVO:61388980
Keywords : electron diffraction * halogen bond * ab-initio
Subject RIV: CF - Physical ; Theoretical Chemistry; CA - Inorganic Chemistry (UACH-T)
Impact factor: 3.474, year: 2016
http://pubs.rsc.org/en/content/articlehtml/2016/ce/c6ce01861k
Permanent Link: http://hdl.handle.net/11104/0268519File Download Size Commentary Version Access Chalcogens.pdf 0 2.1 MB CC BY-NC 3.0 licence Author’s postprint require - 10.0469318 - ÚOCHB 2017 RIV DE eng J - Journal Article
Fanfrlík, Jindřich - Holub, Josef - Růžičková, Z. - Řezáč, Jan - Lane, P. D. - Wann, D. A. - Hnyk, Drahomír - Růžička, A. - Hobza, Pavel
Competition between Halogen, Hydrogen and Dihydrogen Bonding in Brominated Carboranes.
ChemPhysChem. Roč. 17, č. 21 (2016), s. 3373-3376. ISSN 1439-4235. E-ISSN 1439-7641
R&D Projects: GA ČR(CZ) GBP208/12/G016; GA ČR(CZ) GA15-05677S
Institutional support: RVO:61388963 ; RVO:61388980
Keywords : bromine * carboranes * halogen bonds * sigma holes * X-ray crystal structure
Subject RIV: CF - Physical ; Theoretical Chemistry; CA - Inorganic Chemistry (UACH-T)
Impact factor: 3.075, year: 2016
Permanent Link: http://hdl.handle.net/11104/0267126