Search results
- 1.0579081 - ÚMG 2024 RIV US eng J - Journal Article
Jorda, R. - Havlíček, L. - Peřina, M. - Vojáčková, V. - Pospíšil, T. - Djukic, S. - Škerlová, Jana - Grúz, J. - Renešová, N. - Klener, P. - Řezáčová, P. - Strnad, M. - Kryštof, V.
3,5,7-Substituted Pyrazolo[4,3-id/i]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders.
Journal of Medicinal Chemistry. Roč. 65, č. 13 (2022), s. 8881-8896. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:68378050
Keywords : roscovitine * expression * cell line
OECD category: Biochemistry and molecular biology
Impact factor: 7.3, year: 2022
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c02184
Permanent Link: https://hdl.handle.net/11104/0347953 - 2.0556295 - ÚMG 2022 RIV US eng J - Journal Article
Dayal, N. - Řezníčková, E. - Hernandez, D. - Peřina, M. - Torregrosa-Allen, S. - Elzey, B. D. - Škerlová, Jana - Ajani, H. - Djukic, S. - Vojáčková, V. - Lepšík, M. - Řezáčová, Pavlína - Krystof, V. - Jorda, R. - Sintim, H. O.
3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo.
Journal of Medicinal Chemistry. Roč. 64, č. 15 (2021), s. 10981-10996. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:68378050
Keywords : discovery * flt3
OECD category: Biochemistry and molecular biology
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00330
Permanent Link: http://hdl.handle.net/11104/0330582 - 3.0548549 - ÚMG 2022 RIV GB eng J - Journal Article
Šoltysová, M. - Sieglová, Irena - Fábry, Milan - Brynda, Jiří - Škerlová, Jana - Řezáčová, Pavlína
Structural insight into DNA recognition by bacterial transcriptional regulators of the SorC/DeoR family.
Acta Crystallographica Section D-Structural Biology. Roč. 77, č. 11 (2021), s. 1411-1424. ISSN 2059-7983. E-ISSN 2059-7983
Institutional support: RVO:68378050
Keywords : SorC/DeoR family * protein-DNA complexes * transcription repressors * Bacillus subtilis * deoxyribonucleoside regulator bsDeoR * gene regulator bsCggR * carbohydrate catabolism
OECD category: Biochemistry and molecular biology
Impact factor: 5.699, year: 2021
Method of publishing: Limited access
https://scripts.iucr.org/cgi-bin/paper?S2059798321009633
Permanent Link: http://hdl.handle.net/11104/0324596 - 4.0544836 - ÚMG 2022 RIV GB eng J - Journal Article
Vuorio, J. - Škerlová, Jana - Fábry, Milan - Veverka, V. - Vattulainen, I. - Řezáčová, Pavlína - Martinez-Seara, H.
N-Glycosylation can selectively block or foster different receptor-ligand binding modes.
Scientific Reports. Roč. 11, č. 1 (2021), č. článku 5239. ISSN 2045-2322. E-ISSN 2045-2322
Institutional support: RVO:68378050
Keywords : N-glycosylation * simulations and NMR * importance of glycosylation in protein function
OECD category: Cell biology
Impact factor: 4.997, year: 2021
Method of publishing: Open access
https://www.nature.com/articles/s41598-021-84569-z
Permanent Link: http://hdl.handle.net/11104/0321647 - 5.0541528 - ÚMG 2021 RIV US eng J - Journal Article
Jorda, R. - Havlíček, L. - Šturc, A. - Tušková, D. - Daumová, L. - Alam, M. - Škerlová, Jana - Nekardová, M. - Peřina, M. - Pospíšil, T. - Šiiroká, J. - Urbánek, L. - Pachl, P. - Řezáčová, Pavlína - Strnad, M. - Klener, P. - Kryštof, V.
3,5,7-Substituted Pyrazolo[4,3-d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.
Journal of Medicinal Chemistry. Roč. 62, č. 9 (2019), s. 4606-4623. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:68378050
Keywords : biological evaluation * cell-cycle * roscovitine * potent * apoptosis * subgroups * purines * abt-199
OECD category: Biochemistry and molecular biology
Impact factor: 6.205, year: 2019
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00189
Permanent Link: http://hdl.handle.net/11104/0319083 - 6.0494676 - ÚMG 2019 RIV GB eng J - Journal Article
Plavsa, J. J. - Řezáčová, Pavlína - Kugler, Michael - Pachl, P. - Brynda, Jiří - Voburka, Z. - Ćelić, A. - Petri, E. T. - Škerlová, Jana
In situ proteolysis of an N-terminal His tag with thrombin improves the diffraction quality of human aldo-keto reductase 1C3 crystals.
Acta Crystallographica Section F-Structural Biology Communications. Roč. 74, Květen (2018), s. 300-306. E-ISSN 2053-230X
Institutional support: RVO:68378050
Keywords : aldo-keto reductase 1C3 * in situ proteolysis * His tags * diffraction-quality improvement * pET-28(+) * 17 beta-hydroxysteroid dehydrogenase 5
OECD category: Biochemistry and molecular biology
Impact factor: 1.199, year: 2018
Permanent Link: http://hdl.handle.net/11104/0287778 - 7.0491223 - ÚMG 2019 RIV GB eng J - Journal Article
Škerlová, Jana - Bláha, J. - Pachl, Petr - Hofbauerová, Kateřina - Kukačka, Zdeněk - Man, Petr - Pompach, Petr - Novák, Petr - Otwinowski, Z. - Brynda, Jiří - Vaněk, O. - Řezáčová, Pavlína
Crystal structure of native beta-N-acetylhexosaminidase isolated from Aspergillus oryzae sheds light onto its substrate specificity, high stability, and regulation by propeptide.
FEBS Journal. Roč. 285, č. 3 (2018), s. 580-598. ISSN 1742-464X. E-ISSN 1742-4658
R&D Projects: GA MŠMT(CZ) ED1.1.00/02.0109; GA MŠMT(CZ) LO1304; GA MŠMT(CZ) LO1509; GA MŠMT(CZ) LQ1604; GA MŠMT LG14009; GA MŠMT(CZ) LH15010; GA MŠMT(CZ) LM2015043; GA MŠMT(CZ) LD15089; GA ČR(CZ) GA15-05677S; GA ČR(CZ) GA16-24309S; GA ČR(CZ) GA15-15181S
Institutional support: RVO:68378050 ; RVO:61388971
Keywords : active pocket * carbohydrate biotechnology * glycosylation * mass spectrometry * propeptide * X-ray crystallography
OECD category: Biochemistry and molecular biology; Biochemistry and molecular biology (MBU-M)
Impact factor: 4.739, year: 2018
Permanent Link: http://hdl.handle.net/11104/0285263 - 8.0455882 - ÚMG 2016 RIV US eng J - Journal Article
Škerlová, Jana - Král, Vlastimil - Kachala, M. - Fábry, Milan - Bumba, Ladislav - Svergun, D.I. - Tosner, Z. - Veverka, V. - Řezáčová, Pavlína
Molecular mechanism for the action of the anti-CD44 monoclonal antibody MEM-85.
Journal of Structural Biology. Roč. 191, č. 2 (2015), s. 214-223. ISSN 1047-8477. E-ISSN 1095-8657
R&D Projects: GA ČR(CZ) GA15-11851S
EU Projects: European Commission 264257
Institutional support: RVO:68378050 ; RVO:61388971
Keywords : CD44 * Epitope mapping * Monoclonal antibody * MEM-85 * SAXS * NMR
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.570, year: 2015
Permanent Link: http://hdl.handle.net/11104/0256481File Download Size Commentary Version Access Journal_of_Structural_Biology_J_Skerlova_2015.pdf 5 1.7 MB Publisher’s postprint require - 9.0438427 - ÚOCHB 2015 RIV GB eng J - Journal Article
Škerlová, Jana - Král, Vlastimil - Fábry, Milan - Sedláček, Juraj - Veverka, Václav - Řezáčová, Pavlína
Optimization of the crystallizability of a single-chain antibody fragment.
Acta Crystallographica Section F-Structural Biology and Crystallization Communications. Roč. 70, č. 12 (2014), s. 1701-1706. ISSN 1744-3091. E-ISSN 2053-230X
R&D Projects: GA MŠMT(CZ) LK11205
Institutional support: RVO:61388963 ; RVO:68378050
Keywords : single-chain antibody fragment * Thermofluor assay * differential scanning fluorimetry * crystallizability optimization * oligomerization * crystallization
Subject RIV: CE - Biochemistry
Impact factor: 0.524, year: 2014
Permanent Link: http://hdl.handle.net/11104/0242439