Search results
- 1.0587259 - ÚOCHB 2025 RIV NL eng J - Journal Article
Bach, Kathrin - Dohnálek, Jan - Škerlová, Jana - Kumzík, Ján - Poláchová, Edita - Stanchev, Stancho - Majer, Pavel - Fanfrlík, Jindřich - Pecina, Adam - Řezáč, Jan - Lepšík, Martin - Borshchevskiy, V. - Polovinkin, V. - Stříšovský, Kvido
Extensive targeting of chemical space at the prime side of ketoamide inhibitors of rhomboid proteases by branched substituents empowers their selectivity and potency.
European Journal of Medicinal Chemistry. (2024), č. článku 116606. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA21-24456S; GA MŠMT(CZ) LUC23180; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT LX22NPO5102
Research Infrastructure: e-INFRA CZ II - 90254
Institutional support: RVO:61388963
Impact factor: 6.7, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.ejmech.2024.116606
Permanent Link: https://hdl.handle.net/11104/0354501File Download Size Commentary Version Access 10.1016j.ejmech.2024.116606.pdf 0 6.6 MB Publisher’s postprint open-access - 2.0586786 - ÚOCHB 2025 RIV US eng J - Journal Article
Šoltysová, Markéta - Škerlová, Jana - Pachl, Petr - Škubník, K. - Fábry, Milan - Sieglová, Irena - Farolfi, Martina - Grishkovskaya, I. - Babiak, M. - Nováček, J. - Krásný, Libor - Řezáčová, Pavlína
Structural characterization of two prototypical repressors of SorC family reveals tetrameric assemblies on DNA and mechanism of function.
Nucleic Acids Research. (2024), č. článku gkae434. ISSN 0305-1048. E-ISSN 1362-4962
R&D Projects: GA MŠMT(CZ) LX22NPO5103; GA MŠMT(CZ) EH22_008/0004575
Institutional support: RVO:61388963 ; RVO:61388971
Impact factor: 14.9, year: 2022
Method of publishing: Open access
https://doi.org/10.1093/nar/gkae434
Permanent Link: https://hdl.handle.net/11104/0354179File Download Size Commentary Version Access 10.1093nargkae434.pdf 1 2.3 MB Publisher’s postprint open-access - 3.0576863 - ÚOCHB 2025 RIV GB eng J - Journal Article
Kosenina, S. - Škerlová, Jana - Zhang, S. - Dong, M. - Stenmark, P.
The cryo-EM structure of the BoNT/Wo-NTNH complex reveals two immunoglobulin-like domains.
FEBS Journal. Roč. 291, č. 4 (2024), s. 676-689. ISSN 1742-464X. E-ISSN 1742-4658
R&D Projects: GA MŠMT(CZ) EF16_027/0008477
Institutional support: RVO:61388963
Keywords : BoNT-NTNH complex * botulinum neurotoxins * cryo-EM structure * Weissella oryzae
OECD category: Medicinal chemistry
Impact factor: 5.4, year: 2022
Method of publishing: Open access
https://doi.org/10.1111/febs.16964
Permanent Link: https://hdl.handle.net/11104/0346268 - 4.0575033 - ÚOCHB 2024 RIV US eng J - Journal Article
Koutná, Eliška - Lux, Vanda - Kouba, Tomáš - Škerlová, Jana - Nováček, J. - Srb, Pavel - Hexnerová, Rozálie - Šváchová, Hana - Kukačka, Zdeněk - Novák, Petr - Fábry, Milan - Poepsel, S. - Veverka, Václav
Multivalency of nucleosome recognition by LEDGF.
Nucleic Acids Research. Roč. 51, č. 18 (2023), s. 10011-10025. ISSN 0305-1048. E-ISSN 1362-4962
R&D Projects: GA ČR(CZ) GA22-03028S; GA ČR(CZ) GA22-27695S; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LO1304
Research Infrastructure: CIISB II - 90127; CIISB III - 90242
Institutional support: RVO:61388963 ; RVO:61388971
Keywords : PWWP domain * recombinant histones * structural basis
OECD category: Biochemistry and molecular biology; Biochemistry and molecular biology (MBU-M)
Impact factor: 14.9, year: 2022
Method of publishing: Open access
https://doi.org/10.1093/nar/gkad674
Permanent Link: https://hdl.handle.net/11104/0344870 - 5.0571975 - ÚEB 2024 RIV NL eng J - Journal Article
Kovalová, M. - Havlíček, Libor - Djukic, Stefan - Škerlová, Jana - Peřina, M. - Pospíšil, T. - Řezníčková, E. - Řezáčová, Pavlína - Jorda, R. - Kryštof, V.
Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7.
Biomedicine & Pharmacotherapy. Roč. 161, MAY (2023), č. článku 114492. ISSN 0753-3322. E-ISSN 1950-6007
R&D Projects: GA MŠMT LX22NPO5102
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : Cyclin-dependent kinase 7 * Inhibitor * pyrazolo[4,3-d]pyrimidine * Selectivity
OECD category: Medicinal chemistry
Impact factor: 7.5, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.biopha.2023.114492
Permanent Link: https://hdl.handle.net/11104/0342824File Download Size Commentary Version Access 2023_Kovalova_BIOMEDICINE & PHARMACOTHERAPY_114492.pdf 2 3.3 MB Other open-access - 6.0569100 - ÚOCHB 2024 RIV GB eng J - Journal Article
Marinovic, M. A. - Bekic, S. S. - Kugler, Michael - Brynda, Jiří - Škerlová, Jana - Skoric, D. D. - Řezáčová, Pavlína - Petri, E. T. - Celic, A. S.
X-ray structure of human aldo-keto reductase 1C3 in complex with a bile acid fused tetrazole inhibitor: experimental validation, molecular docking and structural analysis.
RSC MEDICINAL CHEMISTRY. Roč. 14, č. 2 (2023), s. 341-355. E-ISSN 2632-8682
R&D Projects: GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : prostaglandin-F synthase * crystal structures * CCP4 suite
OECD category: Biochemistry and molecular biology
Impact factor: 4.1, year: 2022
Method of publishing: Open access
https://doi.org/10.1039/D2MD00387B
Permanent Link: https://hdl.handle.net/11104/0340422File Download Size Commentary Version Access 10.1039d2md00387b.pdf 0 2.6 MB Publisher’s postprint open-access - 7.0562052 - ÚEB 2023 RIV US eng J - Journal Article
Jorda, R. - Havlíček, Libor - Peřina, M. - Vojáčková, V. - Pospíšil, T. - Djukic, Stefan - Škerlová, Jana - Grúz, J. - Renešová, N. - Klener, P. - Řezáčová, Pavlína - Strnad, Miroslav - Kryštof, V.
3,5,7-Substituted Pyrazolo[4,3- d]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders.
Journal of Medicinal Chemistry. Roč. 65, č. 13 (2022), s. 8881-8896. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA ČR(CZ) GA20-25308S
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : Antineoplastic Agents * Cell Line * Cyclin-Dependent Kinases
OECD category: Organic chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c02184
Permanent Link: https://hdl.handle.net/11104/0334472File Download Size Commentary Version Access 2022_Jorda_JOURNAL OF MEDICINAL CHEMISTRY_8881.pdf 3 9 MB Other require - 8.0560182 - ÚOCHB 2023 RIV US eng J - Journal Article
Prejano, M. - Škerlová, Jana - Stenmark, P. - Himo, F.
Reaction Mechanism of Human PAICS Elucidated by Quantum Chemical Calculations.
Journal of the American Chemical Society. Roč. 144, č. 31 (2022), s. 14258-14268. ISSN 0002-7863. E-ISSN 1520-5126
Institutional support: RVO:61388963
Keywords : N-5-carboxyaminoimidazole ribonucleotide mutase * X-ray diffraction * enzyme SAICAR synthase
OECD category: Biochemistry and molecular biology
Impact factor: 15, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/jacs.2c05072
Permanent Link: https://hdl.handle.net/11104/0333192 - 9.0548688 - ÚOCHB 2022 RIV GB eng J - Journal Article
Šoltysová, Markéta - Sieglová, Irena - Fábry, M. - Brynda, Jiří - Škerlová, Jana - Řezáčová, Pavlína
Structural insight into DNA recognition by bacterial transcriptional regulators of the SorC/DeoR family.
Acta Crystallographica Section D-Structural Biology. Roč. 77, č. 11 (2021), s. 1411-1424. ISSN 2059-7983. E-ISSN 2059-7983
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : SorC/DeoR family * protein–DNA complexes * transcription repressors * Bacillus subtilis * deoxyribonucleoside regulator bsDeoR * gene regulator bsCggR * carbohydrate catabolism
OECD category: Biochemistry and molecular biology
Impact factor: 5.699, year: 2021
Method of publishing: Limited access
https://doi.org/10.1107/S2059798321009633
Permanent Link: http://hdl.handle.net/11104/0324739 - 10.0545107 - ÚOCHB 2022 RIV US eng J - Journal Article
Dayal, N. - Řezníčková, E. - Hernandez, D. E. - Peřina, M. - Torregrosa-Allen, S. - Elzey, B. D. - Škerlová, Jana - Ajani, Haresh - Djukic, Stefan - Vojáčková, V. - Lepšík, Martin - Řezáčová, Pavlína - Kryštof, V. - Jorda, R. - Sintim, H. O.
3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo.
Journal of Medicinal Chemistry. Roč. 64, č. 15 (2021), s. 10981-10996. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Research Infrastructure: e-INFRA CZ - 90140
Institutional support: RVO:61388963
Keywords : discovery * FLT3 * cell proliferation
OECD category: Medicinal chemistry
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c00330
Permanent Link: http://hdl.handle.net/11104/0321867