Search results

  1. 1.
    0578510 - ÚOCHB 2024 RIV US eng J - Journal Article
    Novotná, Kateřina - Tenora, Lukáš - Prchalová, E. - Paule, J. - Alt, J. - Veeravalli, V. - Lam, J. - Wu, Y. - Šnajdr, Ivan - Gori, S. - Mettu, V. S. - Tsukamoto, T. - Majer, Pavel - Slusher, B. S. - Rais, R.
    Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-L-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery.
    Journal of Medicinal Chemistry. Roč. 66, č. 22 (2023), s. 15493-15510. ISSN 0022-2623. E-ISSN 1520-4804
    R&D Projects: GA MŠMT LTAUSA18166; GA MŠMT LX22NPO5102
    Institutional support: RVO:61388963
    Keywords : phase-I * 6-diazo-5-oxo-l-norleucine DON * clinical pharmacology
    OECD category: Organic chemistry
    Impact factor: 7.3, year: 2022
    Method of publishing: Open access
    https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01681
    Permanent Link: https://hdl.handle.net/11104/0347498
    FileDownloadSizeCommentaryVersionAccess
    10.1021acs.jmedchem.3c01681.pdf02.8 MBPublisher’s postprintopen-access
     
     
  2. 2.
    0576214 - ÚOCHB 2024 RIV US eng J - Journal Article
    Lemberg, K. M. - Ali, E. S. - Krečmerová, Marcela - Aguilar, J. M. H. - Alt, J. - Peters, D. E. - Zhao, L. - Wu, Y. - Nuha, N. - Asara, J. M. - Staedtke, V. - Pratilas, C. A. - Majer, Pavel - Rais, R. - Ben-Sahra, I. - Slusher, B. S.
    Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor.
    Molecular Cancer Therapeutics. Roč. 22, č. 12 (2023), s. 1390-1403. ISSN 1535-7163. E-ISSN 1538-8514
    R&D Projects: GA MŠMT(CZ) LM2023053
    Institutional support: RVO:61388963
    Keywords : loading 6-mercaptopurine therapies * standard dose 6-mercaptopurine * combination 6-mercaptopurine
    OECD category: Medicinal chemistry
    Impact factor: 5.7, year: 2022
    Method of publishing: Open access
    https://doi.org/10.1158/1535-7163.MCT-23-0258
    Permanent Link: https://hdl.handle.net/11104/0345801
     
     
  3. 3.
    0574388 - ÚOCHB 2024 RIV US eng J - Journal Article
    Peters, D. E. - Norris, L. D. - Tenora, Lukáš - Šnajdr, Ivan - Ponti, A. K. - Zhu, X. - Sakamoto, S. - Veeravalli, V. - Pradhan, M. - Alt, J. - Thomas, A. G. - Majer, Pavel - Rais, R. - McDonald, C. - Slusher, B. S.
    A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis.
    Science Translational Medicine. Roč. 15, č. 708 (2023), č. článku eabn7491. ISSN 1946-6234. E-ISSN 1946-6242
    R&D Projects: GA MŠMT(CZ) LM2018133
    Institutional support: RVO:61388963
    Keywords : gene expression profiles * dextran sulfate sodium * membrane antigen PSMA
    OECD category: Medicinal chemistry
    Impact factor: 17.1, year: 2022
    Method of publishing: Limited access
    https://doi.org/10.1126/scitranslmed.abn7491
    Permanent Link: https://hdl.handle.net/11104/0344718
     
     
  4. 4.
    0574332 - ÚOCHB 2024 RIV NL eng J - Journal Article
    Novotná, Kateřina - Thomas, A. G. - Štěpánek, O. - Murphy, B. - Hin, N. - Skácel, J. - Mueller, L. - Tenora, Lukáš - Pal, A. - Alt, J. - Wu, Y. - Paule, J. - Rais, R. - Slusher, B. S. - Tsukamoto, T.
    Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold.
    European Journal of Medicinal Chemistry. Roč. 259, November (2023), č. článku 115674. ISSN 0223-5234. E-ISSN 1768-3254
    Institutional support: RVO:61388963
    Keywords : phosphodiesterase * neutral sphingomyelinase 2 * ceramide * sphingomyelin * pyrazolo[1,5-a]pyrimidin-3-amine
    OECD category: Medicinal chemistry
    Impact factor: 6.7, year: 2022
    Method of publishing: Limited access
    https://doi.org/10.1016/j.ejmech.2023.115674
    Permanent Link: https://hdl.handle.net/11104/0344672
     
     
  5. 5.
    0568134 - ÚOCHB 2024 RIV GB eng J - Journal Article
    Tsai, J. - Gori, S. - Alt, J. - Tiwari, S. - Iyer, J. - Talwar, R. - Hinsu, D. - Ahirwar, K. - Mohanty, S. - Khunt, C. - Sutariya, B. - Jani, K. - Venkatasubbaiah, V. - Patel, A. - Meghapara, J. - Joshi, K. - Sahu, R. - Rana, V. - Nigade, P. - Talluri, R. S. - Murty, K. V. S. N. - Joshi, K. - Ramanathan, V. - Li, A. - Islam, N. - Šnajdr, Ivan - Majer, Pavel - Rais, R. - Slusher, B. S. - Garza, L. A.
    Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata.
    PNAS Nexus. Roč. 2, č. 1 (2023), č. článku pgac297. E-ISSN 2752-6542
    Institutional support: RVO:61388963
    Keywords : alopecia areata * hair growth * topical * itaconate * prodrug * inflammation * immunosuppression * cytokine * interleukin * interferon * double-stranded RNA * polyinosinic–polycytidylic acid * hair cycle * anagen * telogen * keratinocyte * stability * pharmacokinetics * cytotoxicity
    OECD category: Medicinal chemistry
    Method of publishing: Open access
    https://doi.org/10.1093/pnasnexus/pgac297
    Permanent Link: https://hdl.handle.net/11104/0339488
     

    Research data: Mendeley Data
     
  6. 6.
    0565069 - ÚOCHB 2023 RIV US eng J - Journal Article
    Rais, R. - Lemberg, K. M. - Tenora, Lukáš - Arwood, M. L. - Pal, A. - Alt, J. - Wu, Y. - Lam, J. - Aguilar, J. M. H. - Zhao, L. - Peters, D. E. - Tallon, C. - Pandey, R. - Thomas, A. G. - Dash, R. P. - Seiwert, T. - Majer, Pavel - Leone, R. D. - Powell, J. D. - Slusher, B. S.
    Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
    Science Advances. Roč. 8, č. 46 (2022), č. článku eabq5925. ISSN 2375-2548. E-ISSN 2375-2548
    R&D Projects: GA MŠMT LTAUSA18166
    Institutional support: RVO:61388963
    Keywords : 6-diazo-5-oxo-l-norleucine DON * phase II * glutamine metabolism
    OECD category: Organic chemistry
    Impact factor: 13.6, year: 2022
    Method of publishing: Open access
    https://doi.org/10.1126/sciadv.abq5925
    Permanent Link: https://hdl.handle.net/11104/0336617
     
     
  7. 7.
    0547369 - ÚOCHB 2022 RIV AE eng J - Journal Article
    Alt, J. - Gori, S. S. - Lemberg, K. M. - Pal, A. - Veeravalli, V. - Wu, Y. - Aguilar, J. M. H. - Dash, R. P. - Tenora, Lukáš - Majer, Pavel - Sun, Q. - Slusher, B. S. - Rais, R.
    Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement.
    Current Drug Metabolism. Roč. 22, č. 9 (2021), s. 735-745. ISSN 1389-2002. E-ISSN 1875-5453
    R&D Projects: GA MŠMT LTAUSA18166
    Institutional support: RVO:61388963
    Keywords : Glutamine antagonist * purine synthesis * formylglycinamide ribonucleotide * formylglycinamidine ribonucleotide * biomarker * cancer * LC-MS
    OECD category: Organic chemistry
    Impact factor: 3.408, year: 2021
    Method of publishing: Limited access
    https://doi.org/10.2174/1389200222666210831125041
    Permanent Link: http://hdl.handle.net/11104/0323608
     
     
  8. 8.
    0522291 - ÚOCHB 2021 RIV US eng J - Journal Article
    Lemberg, K. M. - Zhao, L. - Wu, Y. - Veeravalli, V. - Alt, J. - Aguilar, J. M. H. - Dash, R. P. - Lam, J. - Tenora, Lukáš - Rodriguez, C. - Nedelcovych, M. T. - Brayton, C. - Majer, Pavel - Blakeley, J. O. - Rais, R. - Slusher, B. S.
    The Novel Glutamine Antagonist Prodrug JHU395 Has Antitumor Activity in Malignant Peripheral Nerve Sheath Tumor.
    Molecular Cancer Therapeutics. Roč. 19, č. 2 (2020), s. 397-408. ISSN 1535-7163. E-ISSN 1538-8514
    R&D Projects: GA MŠMT LTAUSA18166
    Institutional support: RVO:61388963
    Keywords : 6-diazo-5-oxo-L-norleucine DON * cancer * metabolism
    OECD category: Organic chemistry
    Impact factor: 6.261, year: 2020
    Method of publishing: Limited access
    https://mct.aacrjournals.org/content/19/2/397
    Permanent Link: http://hdl.handle.net/11104/0306808
     
     
  9. 9.
    0510193 - ÚOCHB 2020 RIV US eng J - Journal Article
    Dash, R. P. - Tichý, Tomáš - Veeravalli, V. - Lam, J. - Alt, J. - Wu, Y. - Tenora, Lukáš - Majer, Pavel - Slusher, B. S. - Rais, R.
    Enhanced Oral Bioavailability of 2-(Phosphonomethyl)-pentanedioic Acid (2-PMPA) from its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs.
    Molecular Pharmaceutics. Roč. 16, č. 10 (2019), s. 4292-4301. ISSN 1543-8384. E-ISSN 1543-8392
    Institutional support: RVO:61388963
    Keywords : 2-PMPA * glutamate carboxypeptidase II * oral bioavailability * pharmacokinetics * prodrugs
    OECD category: Organic chemistry
    Impact factor: 4.321, year: 2019
    Method of publishing: Limited access
    https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b00637
    Permanent Link: http://hdl.handle.net/11104/0300720
     
     
  10. 10.
    0504477 - ÚOCHB 2020 RIV US eng J - Journal Article
    Tenora, Lukáš - Alt, J. - Dash, R. P. - Gadiano, A. J. - Novotná, Kateřina - Veeravalli, V. - Lam, J. - Kirkpatrick, Q. R. - Lemberg, K. M. - Majer, Pavel - Rais, R. - Slusher, B. S.
    Tumor-Targeted Delivery of 6-Diazo-5-oxo-L-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs.
    Journal of Medicinal Chemistry. Roč. 62, č. 7 (2019), s. 3524-3538. ISSN 0022-2623. E-ISSN 1520-4804
    R&D Projects: GA MŠMT LTAUSA18166
    Institutional support: RVO:61388963
    Keywords : phase II * doxorubicin prodrugs * cathepsin B
    OECD category: Organic chemistry
    Impact factor: 6.205, year: 2019
    Method of publishing: Limited access
    https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b02009
    Permanent Link: http://hdl.handle.net/11104/0296099
     
     

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