Search results
- 1.0498560 - ÚOCHB 2019 RIV FR eng J - Journal Article
Eng, W. S. - Rejman, Dominik - Pohl, Radek - West, N. P. - Woods, K. - Naesens, L. M. J. - Keough, D. T. - Guddat, L. W.
Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase.
European Journal of Medicinal Chemistry. Roč. 159, Nov 5 (2018), s. 10-22. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MZd(CZ) NV17-29680A; GA ČR GA15-11711S
Institutional support: RVO:61388963
Keywords : Mycobacterium tuberculosis * therapeutic drug leads * X-ray crystal structures * hypoxanthine-guanine phosphoribosyltransferase * pyrrolidine nucleoside phosphonates * pyrrolidine nucleoside bisphosphonates * phosphoramidate prodrugs
OECD category: Organic chemistry
Impact factor: 4.833, year: 2018
Permanent Link: http://hdl.handle.net/11104/0290893 - 2.0445809 - ÚOCHB 2016 RIV US eng J - Journal Article
Eng, W. S. - Hocková, Dana - Špaček, Petr - Janeba, Zlatko - West, N. P. - Woods, K. - Naesens, L. M. J. - Keough, D. T. - Guddat, L. W.
First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.
Journal of Medicinal Chemistry. Roč. 58, č. 11 (2015), s. 4822-4838. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GAP207/11/0108; GA MV VG20102015046
Institutional support: RVO:61388963
Keywords : enzyme inhibitors * nucleotide analogues * tuberculosis * crystal structures
Subject RIV: CC - Organic Chemistry
Impact factor: 5.589, year: 2015
Permanent Link: http://hdl.handle.net/11104/0247858 - 3.0421911 - ÚOCHB 2014 RIV US eng J - Journal Article
Keough, D. T. - Hocková, Dana - Rejman, Dominik - Špaček, Petr - Vrbková, Silvie - Krečmerová, Marcela - Eng, W. S. - Jans, H. - West, N. P. - Naesens, L. M. J. - de Jersey, J. - Guddat, L. W.
Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents.
Journal of Medicinal Chemistry. Roč. 56, č. 17 (2013), s. 6967-6984. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GAP207/11/0108
Institutional support: RVO:61388963
Keywords : nucleoside phosphonates * antibacterial agents * hypoxanthine-guanine phosphoribosyltransferase * state analog inhibitor * antimalarial chemotherapy
Subject RIV: CC - Organic Chemistry
Impact factor: 5.480, year: 2013
Permanent Link: http://hdl.handle.net/11104/0228188