Search results
- 1.0571539 - BTÚ 2024 RIV US eng J - Journal Article
Temml, V. - Kollar, J. - Schoenleitner, T. - Hoell, A. - Schuster, D. - Kutil, Zsofia
Combination of In Silico and In Vitro Screening to Identify Novel Glutamate II Inhibitors.
Journal of Chemical Information and Modeling. Roč. 63, č. 4 (2023), s. 1249-1259. ISSN 1549-9596. E-ISSN 1549-960X
R&D Projects: GA ČR(CZ) GJ19-22269Y
Institutional support: RVO:86652036
Keywords : CARBOXYPEPTIDASE-II * PHARMACOPHORE MODELS * POTENT INHIBITORS
OECD category: Analytical chemistry
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acs.jcim.2c01269
Permanent Link: https://hdl.handle.net/11104/0343285 - 2.0570616 - ÚEB 2024 RIV DE eng J - Journal Article
Šíša, Miroslav - Konečný, L. - Temml, V. - Carazo, A. - Mladěnka, P. - Landa, Přemysl
SC-560 and mofezolac isosteres as new potent COX-1 selective inhibitors with antiplatelet effect.
Archiv der Pharmazie. Roč. 356, č. 5 (2023), č. článku e2200549. ISSN 0365-6233. E-ISSN 1521-4184
R&D Projects: GA MŠMT(CZ) LTC18065
Institutional support: RVO:61389030
Keywords : cyclooxygenase * cytotoxicity * docking * platelets * selectivity
OECD category: Organic chemistry
Impact factor: 5.1, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/ardp.202200549
Permanent Link: https://hdl.handle.net/11104/0341920File Download Size Commentary Version Access 2023_Sisa_ARCHIV DER PHARMAZIE_e2200549.pdf 1 1.7 MB Other open-access - 3.0550559 - BTÚ 2022 RIV SE eng J - Journal Article
Temml, V. - Kutil, Zsofia
Structure-based molecular modeling in SAR analysis and lead optimization.
Computational and Structural Biotechnology Journal. Roč. 19, 2021-08-25 (2021), s. 1431-1444. ISSN 2001-0370. E-ISSN 2001-0370
R&D Projects: GA ČR(CZ) GJ19-22269Y
Institutional support: RVO:86652036
Keywords : Docking * Pharmacophore modeling * Lead optimization
OECD category: Biochemistry and molecular biology
Impact factor: 6.155, year: 2021
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S2001037021000696?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0329294 - 4.0547414 - ÚEB 2022 RIV US eng J - Journal Article
Dvořáková, Marcela - Langhansová, Lenka - Temml, V. - Pavičić, Antonio - Vaněk, Tomáš - Landa, Přemysl
Synthesis, Inhibitory Activity, and in Silico Modeling of Selective COX-1 Inhibitors with a Quinazoline Core.
ACS Medicinal Chemistry Letters. Roč. 12, č. 4 (2021), s. 610-616. ISSN 1948-5875
R&D Projects: GA MŠMT(CZ) LTC17048
Institutional support: RVO:61389030
Keywords : Cyclooxygenase * docking * inhibitor * quinazoline * selectivity
OECD category: Organic chemistry
Impact factor: 4.632, year: 2021
Method of publishing: Open access
http://doi.org/10.1021/acsmedchemlett.1c00004
Permanent Link: http://hdl.handle.net/11104/0323654File Download Size Commentary Version Access 2021_Dvorakova_ACS MEDICINAL CHEMISTRY LETTERS_610.pdf 1 4.9 MB Other open-access - 5.0531731 - ÚEB 2021 RIV FR eng J - Journal Article
Šíša, Miroslav - Dvořáková, Marcela - Temml, V. - Jarošová, Veronika - Vaněk, Tomáš - Landa, Přemysl
Synthesis, inhibitory activity and in silico docking of dual COX/5-LOX inhibitors with quinone and resorcinol core.
European Journal of Medicinal Chemistry. Roč. 204, 15 October (2020), č. článku 112620. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) LTC18065
Grant - others:OPPK(CZ) CZ.2.16/3.1.00/ 21519
Institutional support: RVO:61389030
Keywords : 5-Lipoxygenase * Anti-inflammatory activity * Cyclooxygenase * Quinones * Resorcinols
OECD category: Organic chemistry
Impact factor: 6.514, year: 2020
Method of publishing: Open access
http://doi.org/10.1016/j.ejmech.2020.112620
Permanent Link: http://hdl.handle.net/11104/0310351File Download Size Commentary Version Access 2020_Sisa_European Journal of Medicinal Chemistry_112620.pdf 1 1.5 MB Other open-access - 6.0507792 - ÚEB 2020 RIV US eng J - Journal Article
Hošek, J. - Leláková, V. - Bobál, P. - Pížová, H. - Gazdová, M. - Malaník, M. - Jakubczyk, Karolína - Veselý, Ondřej - Landa, Přemysl - Temml, V. - Schuster, D. - Prachyawarakorn, V. - Pailee, P. - Ren, G. - Zpurný, F. - Oravec, Michal - Šmejkal, K.
Prenylated Stilbenoids Affect Inflammation by Inhibiting the NF-κB/AP-1 Signaling Pathway and Cyclooxygenases and Lipoxygenase.
Journal of Natural Products. Roč. 82, č. 7 (2019), s. 1839-1848. ISSN 0163-3864. E-ISSN 1520-6025
R&D Projects: GA ČR(CZ) GA16-07193S; GA MŠMT(CZ) EF16_019/0000797
Institutional support: RVO:61389030 ; RVO:86652079
Keywords : SELECTIVE COX-1 INHIBITION * NF-KAPPA-B * FLAVONOIDS
OECD category: Plant sciences, botany; Plant sciences, botany (UEK-B)
Impact factor: 3.782, year: 2019
Method of publishing: Open access
http://dx.doi.org/10.1021/acs.jnatprod.9b00081
Permanent Link: http://hdl.handle.net/11104/0298762File Download Size Commentary Version Access 2019_Hosek_JOURNAL OF NATURAL PRODUCTS_1839.pdf 9 3.2 MB Other open-access - 7.0502554 - ÚEB 2019 RIV NL eng J - Journal Article
Leláková, V. - Šmejkal, K. - Jakubczyk, Karolína - Veselý, Ondřej - Landa, Přemysl - Václavík, J. - Bobáľ, P. - Pížová, H. - Temml, V. - Steinacher, T. - Schuster, D. - Granica, S. - Hanáková, Z. - Hošek, J.
Parallel in vitro and in silico investigations into anti-inflammatory effects of non-prenylated stilbenoids.
Food Chemistry. Roč. 285, JUL 1 (2019), s. 431-440. ISSN 0308-8146. E-ISSN 1873-7072
R&D Projects: GA ČR(CZ) GA16-07193S
Institutional support: RVO:61389030
Keywords : Anti-inflammatory * Cyclooxygenase * Lipoxygenase * Macrophages * Molecular docking simulations * NF-κB * Stilbenes
OECD category: Biochemical research methods
Impact factor: 6.306, year: 2019
Permanent Link: http://hdl.handle.net/11104/0294459File Download Size Commentary Version Access 2019_Lelakova_FOOD CHEMISTRY_431.pdf 1 2.6 MB Other open-access - 8.0476495 - ÚEB 2018 RIV US eng J - Journal Article
Hanáková, Z. - Hošek, J. - Kutil, Zsófia - Temml, V. - Landa, Přemysl - Vaněk, Tomáš - Schuster, D. - Dall’Acqua, S. - Cvačka, Josef - Polanský, O. - Šmejkal, K.
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.
Journal of Natural Products. Roč. 80, č. 4 (2017), s. 999-1006. ISSN 0163-3864. E-ISSN 1520-6025
Grant - others:GA MŠk(CZ) ED0006/01/01
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : PAULOWNIA-TOMENTOSA FRUITS * PRENYLATED FLAVONOIDS * FLAVANONES
OECD category: Biochemistry and molecular biology
Impact factor: 3.885, year: 2017
Permanent Link: http://hdl.handle.net/11104/0272981File Download Size Commentary Version Access 2017_Hanakova_JOURNAL OF NATURAL PRODUCTS_999.pdf 3 2.1 MB Other open-access - 9.0474823 - ÚEB 2018 RIV GB eng J - Journal Article
Temml, V. - Garscha, U. - Romp, E. - Schubert, G. - Gerstmeier, J. - Kutil, Zsófia - Matuszczak, B. - Waltenberger, B. - Stuppner, H. - Werz, O. - Schuster, D.
Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening.
Scientific Reports. Roč. 7, FEB 20 (2017), č. článku 42751. ISSN 2045-2322. E-ISSN 2045-2322
Institutional support: RVO:61389030
Keywords : activating protein * drug discovery * leukotriene biosynthesis * inflammatory diseases * conformer generation * arachidonic-acid * flap * challenges * asthma * risk
OECD category: Physiology (including cytology)
Impact factor: 4.122, year: 2017
Permanent Link: http://hdl.handle.net/11104/0271773File Download Size Commentary Version Access 2017_Temml_SCIENTIFIC REPORTS_42751.pdf 2 759.2 KB Other open-access - 10.0464466 - ÚEB 2017 RIV DE eng J - Journal Article
Zatelli, G.A. - Temml, V. - Kutil, Zsófia - Landa, Přemysl - Vaněk, Tomáš - Schuster, D. - Falkenberg, M.
Miconidin Acetate and Primin as Potent 5-Lipoxygenase Inhibitors from Brazilian Eugenia hiemalis (Myrtaceae).
Planta Medica Letters. Roč. 3, č. 01 (2016), e17-e19. E-ISSN 2199-157X
Institutional support: RVO:61389030
Keywords : Eugenia hiemalis * Myrtaceae * miconidin acetate
Subject RIV: EF - Botanics
Permanent Link: http://hdl.handle.net/11104/0263318File Download Size Commentary Version Access 2016_Zatelli_Planta Medica Letters_e17.pdf 2 185 KB Other open-access