Search results
- 1.0542010 - ÚOCHB 2022 RIV FR eng J - Journal Article
Frydrych, Jan - Keough, D. T. - Chavchich, M. - Travis, J. - Dračínský, Martin - Edstein, M. D. - Guddat, L. W. - Hocková, Dana - Janeba, Zlatko
Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity.
European Journal of Medicinal Chemistry. Roč. 219, Jul 5 (2021), č. článku 113416. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA19-07707S
Institutional support: RVO:61388963
Keywords : nucleoside phosphonates * phosphoroamidate prodrug * HG(X)PRT * hypoxanthine-guanine-(xanthine) phosphoribosyltransferase * Plasmodium falciparum * Plasmodium vivax
OECD category: Organic chemistry
Impact factor: 7.088, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.ejmech.2021.113416
Permanent Link: http://hdl.handle.net/11104/0319509 - 2.0510479 - ÚOCHB 2020 RIV FR eng J - Journal Article
Klejch, Tomáš - Keough, D. T. - Chavchich, M. - Travis, J. - Skácel, Jan - Pohl, Radek - Janeba, Zlatko - Edstein, M. D. - Avery, V. M. - Guddat, L. W. - Hocková, Dana
Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation.
European Journal of Medicinal Chemistry. Roč. 183, Dec 1 (2019), č. článku 111667. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA16-06049S
Institutional support: RVO:61388963
Keywords : hypoxanthine-guanine-xanthine phosphoribosyltransferase * sulfur-containing drugs * sulfide oxidation * Plasmodium falciparum * acyclic nucleoside phosphonates
OECD category: Organic chemistry
Impact factor: 5.573, year: 2019
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/abs/pii/S0223523419308116?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0300951 - 3.0489497 - ÚOCHB 2019 RIV US eng J - Journal Article
Keough, D. T. - Rejman, Dominik - Pohl, Radek - Zborníková, Eva - Hocková, Dana - Croll, T. - Edstein, M. D. - Birrell, G. W. - Chavchich, M. - Naesens, L. M. J. - Pierens, G. K. - Brereton, I. M. - Guddat, L. W.
Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.
ACS Chemical Biology. Roč. 13, č. 1 (2018), s. 82-90. ISSN 1554-8929. E-ISSN 1554-8937
R&D Projects: GA ČR(CZ) GA16-06049S; GA ČR GA15-11711S
Institutional support: RVO:61388963
Keywords : plasmodium vivax * inhibitor * pyrrolidine nucleotide bisphosphonate * HXGPRT
OECD category: Organic chemistry
Impact factor: 4.374, year: 2018
Permanent Link: http://hdl.handle.net/11104/0283906 - 4.0479744 - ÚOCHB 2018 RIV US eng J - Journal Article
Špaček, Petr - Keough, D. T. - Chavchich, M. - Dračínský, Martin - Janeba, Zlatko - Naesens, L. - Edstein, M. D. - Guddat, L. W. - Hocková, Dana
Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase.
Journal of Medicinal Chemistry. Roč. 60, č. 17 (2017), s. 7539-7554. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR(CZ) GA16-06049S
Institutional support: RVO:61388963
Keywords : hypoxanthine-guanine phosphoribosyltransferase * 2nd phosphonate group * 6-oxopurine phosphoribosyltransferases
OECD category: Organic chemistry
Impact factor: 6.253, year: 2017
Permanent Link: http://hdl.handle.net/11104/0275689 - 5.0477558 - ÚOCHB 2018 RIV GB eng J - Journal Article
Špaček, Petr - Keough, D. T. - Chavchich, M. - Dračínský, Martin - Janeba, Zlatko - Naesens, L. - Edstein, M. D. - Guddat, L. W. - Hocková, Dana
Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs.
Bioorganic & Medicinal Chemistry. Roč. 25, č. 15 (2017), s. 4008-4030. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA ČR(CZ) GA16-06049S
Institutional support: RVO:61388963
Keywords : enzyme inhibitors * nucleotide analogues * malaria
OECD category: Organic chemistry
Impact factor: 2.881, year: 2017
Permanent Link: http://hdl.handle.net/11104/0273877 - 6.0450219 - ÚOCHB 2016 RIV DE eng J - Journal Article
Kaiser, Martin Maxmilian - Hocková, Dana - Wang, T. H. - Dračínský, Martin - Poštová Slavětínská, Lenka - Procházková, Eliška - Edstein, M. D. - Chavchich, M. - Keough, D. T. - Guddat, L. W. - Janeba, Zlatko
Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases.
ChemMedChem. Roč. 10, č. 10 (2015), s. 1707-1723. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA MV VG20102015046; GA ČR GAP207/11/0108
Institutional support: RVO:61388963
Keywords : 6-oxopurine * acyclic nucleoside phosphonates * phosphoribosyltransferases * malaria * phosphoramidates
Subject RIV: CC - Organic Chemistry
Impact factor: 2.980, year: 2015
Permanent Link: http://hdl.handle.net/11104/0251588 - 7.0448335 - ÚOCHB 2016 RIV GB eng J - Journal Article
Hocková, Dana - Janeba, Zlatko - Naesens, L. - Edstein, M. D. - Chavchich, M. - Keough, D. T. - Guddat, L. W.
Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases.
Bioorganic & Medicinal Chemistry. Roč. 23, č. 17 (2015), s. 5502-5510. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA ČR GAP207/11/0108
Institutional support: RVO:61388963
Keywords : nucleotide analogues * enzyme inhibitors * malaria * HG(X)PRT * ANP
Subject RIV: CC - Organic Chemistry
Impact factor: 2.923, year: 2015
Permanent Link: http://hdl.handle.net/11104/0250073 - 8.0443295 - ÚOCHB 2016 RIV US eng J - Journal Article
Keough, D. T. - Hocková, Dana - Janeba, Zlatko - Wang, T. H. - Naesens, L. - Edstein, M. D. - Chavchich, M. - Guddat, L. W.
Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents.
Journal of Medicinal Chemistry. Roč. 58, č. 2 (2015), s. 827-846. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GAP207/11/0108
Institutional support: RVO:61388963
Keywords : enzyme inhibitors * ANPs * Plasmodium * malaria
Subject RIV: CC - Organic Chemistry
Impact factor: 5.589, year: 2015
Permanent Link: http://hdl.handle.net/11104/0246076 - 9.0392258 - ÚOCHB 2014 RIV US eng J - Journal Article
Keough, D. T. - Špaček, Petr - Hocková, Dana - Tichý, Tomáš - Vrbková, S. - Slavětínská, Lenka - Janeba, Zlatko - Naesens, L. - Edstein, M. D. - Chavchich, M. - Wang, T. H. - de Jersey, J. - Guddat, L. W.
Acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group Are Potent Inhibitors of 6-Oxopurine Phosphoribosyltransferases and Have Antimalarial Activity.
Journal of Medicinal Chemistry. Roč. 56, č. 6 (2013), s. 2513-2526. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GAP207/11/0108
Institutional support: RVO:61388963
Keywords : enzyme inhibitors * ANPs * malaria * bisphosphonates
Subject RIV: CC - Organic Chemistry
Impact factor: 5.480, year: 2013
Permanent Link: http://hdl.handle.net/11104/0221165