Search results
- 1.0579804 - ÚMG 2024 RIV US eng J - Journal Article
Mejdrova, I. - Dušek, J. - Škach, K. - Štefela, A. - Škoda, J. - Chalupský, Karel - Dohnalová, Klára - Pávková, I. - Kronenberger, T. - Rashidian, A. - Smutná, L. - Duchoslav, V. - Smutný, T. - Pávek, P. - Nencka, R.
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure.
Journal of Medicinal Chemistry. Roč. 66, č. 4 (2023), s. 2422-2456. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) LM2015040; GA ČR GA22-05167S; GA MŠMT ED2.1.00/19.0395
Institutional support: RVO:68378050
Keywords : pregnane-x-receptor * car * activation * pxr * ligand * derivatives * identification * artemisinin * metabolites * expression
OECD category: Cell biology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01140
Permanent Link: https://hdl.handle.net/11104/0348603 - 2.0559943 - ÚMG 2023 RIV NL eng J - Journal Article
Kracun, D. - Klop, M. - Knirsch, A. - Petry, A. - Kanchev, I. - Chalupský, Karel - Wolf, C.M. - Goerlach, A.
NADPH oxidases and HIF1 promote cardiac dysfunction and pulmonary hypertension in response to glucocorticoid excess.
Redox Biology. Roč. 34, July (2020), č. článku 101536. ISSN 2213-2317. E-ISSN 2213-2317
Institutional support: RVO:68378050
Keywords : NADPH oxidase * p22phox * Glucocorticoid * hif1 * Hypertension * Pulmonary vascular remodeling * ros
OECD category: Biochemistry and molecular biology
Impact factor: 11.799, year: 2020
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S2213231719315198?via%3Dihub
Permanent Link: https://hdl.handle.net/11104/0333063 - 3.0556653 - ÚMG 2023 RIV US eng J - Journal Article
Škoda, J. - Dohnalová, Klára - Chalupský, Karel - Stahl, A. - Templin, M. - Maixnerova, J. - Mičuda, S. - Grontved, L. - Braeuning, A. - Pávek, P.
Off-target lipid metabolism disruption by the mouse constitutive androstane receptor ligand TCPOBOP in humanized mice.
Biochemical Pharmacology. Roč. 197, March (2022), č. článku 114905. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA ČR GA19-14497S
Institutional support: RVO:68378050
Keywords : Nuclear receptors * Endocrine disruptors * Drug interactions * Hepatotoxicity * Humanized mice (HuMice)
OECD category: Pharmacology and pharmacy
Impact factor: 5.8, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0006295221005311?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0330795 - 4.0554674 - MBÚ 2023 RIV CH eng J - Journal Article
Procházková, M. - Budínská, E. - Kuzma, Marek - Pelantová, Helena - Hradecký, J. - Heczková, M. - Dasková, N. - Bratová, M. - Modos, I. - Vídeňská, P. - Šplíchalová, P. - Sowah, S. - Králová, M. - Héniková, S. - Selinger, E. - Klíma, Kryštof - Chalupský, Karel - Sedláček, Radislav - Landberg, R. - Kuehn, T. - Gojda, J. - Cahová, M.
Vegan Diet Is Associated With Favorable Effects on the Metabolic Performance of Intestinal Microbiota: A Cross-Sectional Multi-Omics Study.
Frontiers in Nutrition. Roč. 8, JAN 7 2022 (2022), č. článku 783302. ISSN 2296-861X. E-ISSN 2296-861X
R&D Projects: GA MŠMT(CZ) LM2018126; GA MZd(CZ) NV18-01-00040
Research Infrastructure: CCP II - 90126
Institutional support: RVO:61388971 ; RVO:68378050
Keywords : gut microbiota * hunter-gatherers * vegetarians * acids * prevention * disease * cancer * health * vegan diet * omics signature * protein fermentation * short-chain fatty acids (SCFAs) * metabolic health
OECD category: Endocrinology and metabolism (including diabetes, hormones)
Impact factor: 5, year: 2022
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fnut.2021.783302/full
Permanent Link: http://hdl.handle.net/11104/0331984 - 5.0554370 - ÚMG 2022 RIV CH eng J - Journal Article
Bechyňská, K. - Kosek, V. - Fenclová, M. - Muchová, L. - Smid, V. - Suk, J. - Chalupský, Karel - Sticová, E. - Hůrková, K. - Hajslova, J. - Vítek, L. - Stranská, M.
The Effect of Mycotoxins and Silymarin on Liver Lipidome of Mice with Non-Alcoholic Fatty Liver Disease.
Biomolecules. Roč. 11, č. 11 (2021), č. článku 1723. E-ISSN 2218-273X
R&D Projects: GA MŠMT(CZ) LM2018126; GA MŠMT ED2.1.00/19.0395; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:68378050
Keywords : mycotoxins * silymarin * lipidome * metabolome * mice liver * mass spectrometry
OECD category: Biochemistry and molecular biology
Impact factor: 6.064, year: 2021
Method of publishing: Open access
https://www.mdpi.com/2218-273X/11/11/1723
Permanent Link: http://hdl.handle.net/11104/0328990 - 6.0544584 - ÚMG 2022 RIV GB eng J - Journal Article
Žbodáková, Olga - Chalupský, Karel - Sarnová, Lenka - Kašpárek, Petr - Jiroušková, Markéta - Gregor, Martin - Sedláček, Radislav
ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis.
Scientific Reports. Roč. 11, č. 1 (2021), č. článku 11414. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA MŠMT(CZ) LM2015040; GA MŠMT(CZ) LM2018126; GA MŠMT ED2.1.00/19.0395; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:68378050
Keywords : tumor-necrosis-factor * epidermal-growth-factor * factor-alpha * partial-hepatectomy * factor hgf * receptor * inflammation * disintegrin * activation * resistance
OECD category: Biochemistry and molecular biology
Impact factor: 4.997, year: 2021
Method of publishing: Open access
https://www.nature.com/articles/s41598-021-90716-3
Permanent Link: http://hdl.handle.net/11104/0321426 - 7.0544578 - ÚMG 2022 RIV NL eng J - Journal Article
Schumacher, N. - Yan, K. - Gandrass, M. - Mueller, M. - Krisp, C. - Haesler, R. - Carambia, A. - Nofer, J.R. - Bernardes, J.P. - Khouja, M. - Thomsen, I. - Chalupský, Karel - Bolik, J. - Hoelscher, C. - Wunderlich, T. - Herkel, J. - Rosenstiel, P. - Schramm, C. - Schlueter, H. - Renne, T. - Mittruecker, H.W. - Rose-John, S. - Schmidt-Arras, D.
Cell-autonomous hepatocyte-specific GP130 signaling is sufficient to trigger a robust innate immune response in mice.
Journal of Hepatology. Roč. 74, č. 2 (2021), s. 407-418. ISSN 0168-8278. E-ISSN 1600-0641
Institutional support: RVO:68378050
Keywords : il-6 * gp130 * Acute-phase response * Innate immunity
OECD category: Cell biology
Impact factor: 30.083, year: 2021
Method of publishing: Limited access
https://www.journal-of-hepatology.eu/article/S0168-8278(20)33664-3/fulltext
Permanent Link: http://hdl.handle.net/11104/0321421 - 8.0540344 - ÚMG 2021 RIV GB eng J - Journal Article
Žbodáková, Olga - Chalupský, Karel - Turečková, Jolana - Sedláček, Radislav
Metalloproteinases in liver fibrosis: current insights.
Metalloproteinases In Medicine. Roč. 4, February (2017), s. 25-35. ISSN 2324-2027
R&D Projects: GA MŠMT(CZ) LQ1604
Institutional support: RVO:68378050
Keywords : matrix metalloproteinase * ADAM * liver * fibrosis
OECD category: Genetics and heredity (medical genetics to be 3)
Method of publishing: Limited access
https://www.dovepress.com/metalloproteinases-in-liver-fibrosis-current-insights-peer-reviewed-article-MNM
Permanent Link: http://hdl.handle.net/11104/0317983 - 9.0539733 - ÚMG 2021 RIV CH eng J - Journal Article
Škoda, J. - Dušek, J. - Drastík, M. - Štefela, A. - Dohnalová, Klára - Chalupský, Karel - Smutný, T. - Mičuda, S. - Gerbal-Chaloin, S. - Pávek, P.
Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain.
Cells. Roč. 9, č. 12 (2020), č. článku 2532. E-ISSN 2073-4409
R&D Projects: GA ČR GA19-14497S; GA MŠMT(CZ) LM2018126; GA MŠMT ED2.1.00/19.0395
Institutional support: RVO:68378050
Keywords : diazepam * gene regulation * car * cytochrome P450 * drug interaction
OECD category: Biochemistry and molecular biology
Impact factor: 6.600, year: 2020
Method of publishing: Open access
https://www.mdpi.com/2073-4409/9/12/2532
Permanent Link: http://hdl.handle.net/11104/0317435 - 10.0524265 - MBÚ 2021 RIV US eng J - Journal Article
Budínská, E. - Gojda, J. - Heczková, M. - Bratová, M. - Daňková, H. - Wohl, P. - Baštová, H. - Lánská, V. - Kostovčík, Martin - Dastych, M. - Šenkyřík, M. - Křížová, J. - Mráz, M. - Hradecký, J. - Hajslová, J. - Leníček, M. - Podzimková, K. - Chalupský, Karel - Sedláček, Radislav - Cahová, M.
Microbiome and Metabolome Profiles Associated With Different Types of Short Bowel Syndrome: Implications for Treatment.
Journal of Parenteral and Enteral Nutrition. Roč. 44, č. 1 (2020), s. 105-118. ISSN 0148-6071. E-ISSN 1941-2444
R&D Projects: GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) LM2015040
Institutional support: RVO:61388971 ; RVO:68378050
Keywords : bile acids * gut microbiota * parenteral nutrition
OECD category: Microbiology; Genetics and heredity (medical genetics to be 3) (UMG-J)
Impact factor: 4.016, year: 2020
Method of publishing: Open access
https://d360prx.biomed.cas.cz:2630/doi/pdfdirect/10.1002/jpen.1595
Permanent Link: http://hdl.handle.net/11104/0308646