Search results
- 1.0507827 - FGÚ 2020 RIV US eng J - Journal Article
Sivčev, Sonja - Slavíková, Barbora - Rupert, Marian - Ivetic, Milorad - Nekardová, Michaela - Kudová, Eva - Zemková, Hana
Synthetic testosterone derivatives modulate rat P2X2 and P2X4 receptor channel gating.
Journal of Neurochemistry. Roč. 150, č. 1 (2019), s. 28-43. ISSN 0022-3042. E-ISSN 1471-4159
R&D Projects: GA ČR(CZ) GA16-12695S; GA ČR(CZ) GA18-05413S; GA ČR(CZ) GBP208/12/G016; GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : allosteric modulation * ATP * P2XR * testosterone derivatives * purinergic receptors * ivermectin
OECD category: Neurosciences (including psychophysiology
Impact factor: 4.066, year: 2019
Method of publishing: Open access with time embargo
https://doi.org/10.1111/jnc.14718
Permanent Link: http://hdl.handle.net/11104/0298791 - 2.0505109 - ÚEB 2020 RIV US eng J - Journal Article
Jorda, Radek - Havlíček, Libor - Šturc, Antonín - Tušková, D. - Daumová, L. - Alam, M. - Škerlová, Jana - Nekardová, Michaela - Peřina, Miroslav - Pospíšil, Tomáš - Široká, Jitka - Urbánek, Lubor - Pachl, Petr - Řezáčová, Pavlína - Strnad, Miroslav - Klener, P. - Kryštof, Vladimír
3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.
Journal of Medicinal Chemistry. Roč. 62, č. 9 (2019), s. 4606-4623. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GA17-14007S; GA ČR(CZ) GBP208/12/G016
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : BIOLOGICAL EVALUATION * CELL-CYCLE * ROSCOVITINE
OECD category: Hematology; Medicinal chemistry (UOCHB-X)
Impact factor: 6.205, year: 2019
Method of publishing: Limited access
http://doi.org/10.1021/acs.jmedchem.9b00189
Permanent Link: http://hdl.handle.net/11104/0296627File Download Size Commentary Version Access 2019_Jorda_JOURNAL OF MEDICINAL CHEMISTRY_4606.pdf 4 4.5 MB Other require - 3.0498559 - ÚOCHB 2019 RIV CH eng J - Journal Article
Adla, Santosh Kumar - Slavíková, Barbora - Chodounská, Hana - Vyklický, Vojtěch - Ladislav, Marek - Hubálková, Pavla - Krausová, Barbora - Smejkalová, Tereza - Nekardová, Michaela - Šmídková, Markéta - Monincová, Lenka - Souček, Radko - Vyklický ml., Ladislav - Kudová, Eva
Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif.
Frontiers in Pharmacology. Roč. 9, Nov 12 (2018), č. článku 1299. ISSN 1663-9812. E-ISSN 1663-9812
R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GBP208/12/G016; GA ČR(CZ) GA17-02300S; GA ČR(CZ) GJ16-03913Y; GA MZd(CZ) NV15-29370A; GA MŠMT LO1302; GA MŠMT(CZ) ED1.1.00/02.0109
Grant - others:AV ČR(CZ) MSM200111601
Program: Program na podporu mezinárodní spolupráce začínajících výzkumných pracovníků
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : neurosteroid * amide * NMDA receptor * plasma stability * structure-activity relationship
OECD category: Biochemistry and molecular biology
Impact factor: 3.845, year: 2018
https://www.frontiersin.org/articles/10.3389/fphar.2018.01299/full
Permanent Link: http://hdl.handle.net/11104/0291127 - 4.0490287 - FGÚ 2019 RIV US eng J - Journal Article
Krausová, Barbora - Slavíková, Barbora - Nekardová, Michaela - Hubálková, Pavla - Vyklický, Vojtěch - Chodounská, Hana - Vyklický ml., Ladislav - Kudová, Eva
Positive Modulators of the N-Methyl-D-aspartate Receptor: Structure-Activity Relationship Study of Steroidal 3-Hemiesters.
Journal of Medicinal Chemistry. Roč. 61, č. 10 (2018), s. 4505-4516. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR(CZ) GA17-02300S; GA ČR(CZ) GBP208/12/G016; GA TA ČR(CZ) TE01020028; GA MZd(CZ) NV15-29370A; GA MŠMT(CZ) ED1.1.00/02.0109
Grant - others:AV ČR(CZ) MSM200111601
Program: Program na podporu mezinárodní spolupráce začínajících výzkumných pracovníků
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : neurosteroids * N-Methyl-D-aspartate receptor * positive modulators
OECD category: Neurosciences (including psychophysiology
Impact factor: 6.054, year: 2018
Permanent Link: http://hdl.handle.net/11104/0284547 - 5.0476134 - ÚOCHB 2018 RIV DE eng J - Journal Article
Nekardová, Michaela - Vymětalová, Ladislava - Khirsariya, P. - Kováčová, S. - Hylsová, M. - Jorda, Radek - Kryštof, Vladimír - Fanfrlík, Jindřich - Hobza, Pavel - Paruch, K.
Structural Basis of the Interaction of Cyclin-Dependent Kinase 2 with Roscovitine and Its Analogues Having Bioisosteric Central Heterocycles.
ChemPhysChem. Roč. 18, č. 7 (2017), s. 785-795. ISSN 1439-4235. E-ISSN 1439-7641
R&D Projects: GA ČR(CZ) GBP208/12/G016; GA ČR(CZ) GA15-15264S
Institutional support: RVO:61388963 ; RVO:61389030
Keywords : computational chemistry * enzymes * protein-inhibitor interactions * purine bioisosteres * scaffold hopping
OECD category: Physical chemistry
Impact factor: 2.947, year: 2017
Permanent Link: http://hdl.handle.net/11104/0272666File Download Size Commentary Version Access 2017_Nekardova_CHEMPHYSCHEM_785.pdf 6 3.2 MB Other open-access - 6.0475164 - ÚOCHB 2018 RIV IE eng J - Journal Article
Riedlová, Kamila - Nekardová, Michaela - Kačer, P. - Syslová, K. - Vazdar, M. - Jungwirth, Pavel - Kudová, Eva - Cwiklik, Lukasz
Distributions of therapeutically promising neurosteroids in cellular membranes.
Chemistry and Physics of Lipids. Roč. 203, Mar (2017), s. 78-86. ISSN 0009-3084. E-ISSN 1873-2941
R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GAP303/12/1464; GA ČR GA15-14292S; GA ČR(CZ) GBP208/12/G016
Institutional support: RVO:61388963 ; RVO:61388955
Keywords : steroids * N-methyl-D-aspartate receptors * membranes * molecular dynamics * chromatography
OECD category: Physical chemistry; Physical chemistry (UFCH-W)
Impact factor: 2.766, year: 2017
Permanent Link: http://hdl.handle.net/11104/0272677 - 7.0474432 - ÚOCHB 2018 RIV US eng J - Journal Article
Adla, Santosh Kumar - Slavíková, Barbora - Šmídková, Markéta - Tloušťová, Eva - Svoboda, Martin - Vyklický, Vojtěch - Krausová, Barbora - Hubálková, Pavla - Nekardová, Michaela - Holubová, Kristína - Valeš, Karel - Buděšínský, Miloš - Vyklický ml., Ladislav - Chodounská, Hana - Kudová, Eva
Physicochemical and biological properties of novel amide-based steroidal inhibitors of NMDA receptors.
Steroids. Roč. 117, Jan (2017), s. 52-61. ISSN 0039-128X. E-ISSN 1878-5867.
[Conference on Isoprenoids /23./. Minsk, 04.09.2016-07.09.2016]
R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GAP303/12/1464; GA MŠMT LO1302; GA MZd(CZ) NV15-29370A; GA ČR(CZ) GBP208/12/G016
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : neurosteroid * NMDA receptor * structure-activity relationship * amide * blood-brain-barrier permeability * Caco-2 assay
OECD category: Organic chemistry; Organic chemistry (FGU-C)
Impact factor: 2.523, year: 2017
Permanent Link: http://hdl.handle.net/11104/0271487 - 8.0461780 - ÚOCHB 2017 RIV US eng J - Journal Article
Slavíková, Barbora - Chodounská, Hana - Nekardová, Michaela - Vyklický, Vojtěch - Ladislav, Marek - Hubálková, Pavla - Krausová, Barbora - Vyklický ml., Ladislav - Kudová, Eva
Neurosteroid-like Inhibitors of N-Methyl-D-aspartate Receptor: Substituted 2-Sulfates and 2-Hemisuccinates of Perhydrophenanthrene.
Journal of Medicinal Chemistry. Roč. 59, č. 10 (2016), s. 4724-4739. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GAP303/12/1464; GA MŠMT(CZ) LQ1604; GA ČR(CZ) GBP208/12/G016; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : NMDA receptor * 3 alpha 5 beta-pregnanolone glutamate * noncovalent complexes
Subject RIV: CC - Organic Chemistry; ED - Physiology (FGU-C)
Impact factor: 6.259, year: 2016
Permanent Link: http://hdl.handle.net/11104/0261365 - 9.0459355 - FGÚ 2017 RIV US eng J - Journal Article
Vyklický, Vojtěch - Smejkalová, Tereza - Krausová, Barbora - Balík, Aleš - Kořínek, Miloslav - Borovská, Jiřina - Horák, Martin - Chvojková, Markéta - Kletečková, Lenka - Valeš, Karel - Černý, Jiří - Nekardová, Michaela - Chodounská, Hana - Kudová, Eva - Vyklický ml., Ladislav
Preferential Inhibition of Tonically over Phasically Activated NMDA Receptors by Pregnane Derivatives.
Journal of Neuroscience. Roč. 36, č. 7 (2016), s. 2161-2175. ISSN 0270-6474. E-ISSN 1529-2401
R&D Projects: GA ČR(CZ) GAP303/12/1464; GA ČR(CZ) GBP304/12/G069; GA TA ČR(CZ) TE01020028; GA ČR(CZ) GBP208/12/G016; GA MŠMT(CZ) EE2.3.30.0025; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : memantine * neuroprotection * neurosteroid * NMDA receptor * pregnanolone sulfate * synaptic transmission
Subject RIV: ED - Physiology
Impact factor: 5.988, year: 2016
Permanent Link: http://hdl.handle.net/11104/0259572 - 10.0447623 - ÚOCHB 2016 RIV US eng J - Journal Article
Kudová, Eva - Chodounská, Hana - Slavíková, Barbora - Buděšínský, Miloš - Nekardová, Michaela - Vyklický, Vojtěch - Krausová, Barbora - Švehla, Pavel - Vyklický ml., Ladislav
A New Class of Potent N-Methyl-D-Aspartate Receptor Inhibitors: Sulfated Neuroactive Steroids with Lipophilic D-Ring Modifications.
Journal of Medicinal Chemistry. Roč. 58, č. 15 (2015), s. 5950-5966. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GAP303/12/1464; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : NMDA receptor * noncovalent complexes * neurosteroids
Subject RIV: CC - Organic Chemistry
Impact factor: 5.589, year: 2015
Permanent Link: http://hdl.handle.net/11104/0249424