Search results
- 1.0572565 - ÚOCHB 2024 RIV US eng J - Journal Article
Skácel, Jan - Djukic, Stefan - Baszczyňski, Ondřej - Kalčic, Filip - Bílek, Tadeáš - Chalupský, Karel - Kozák, Jaroslav - Dvořáková, Alexandra - Tloušťová, Eva - Kráľová, Zuzana - Šmídková, Markéta - Voldřich, Jan - Rumlová, M. - Pachl, Petr - Brynda, Jiří - Vučková, Tereza - Fábry, Milan - Snášel, Jan - Pichová, Iva - Řezáčová, Pavlína - Mertlíková-Kaiserová, Helena - Janeba, Zlatko
Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors.
Journal of Medicinal Chemistry. Roč. 66, č. 10 (2023), s. 6652-6681. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA TA ČR(CZ) TN01000013; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : multisubstrate analog inhibitors * transition-state analog * human erythrocytes
OECD category: Organic chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.2c02097
Permanent Link: https://hdl.handle.net/11104/0343213File Download Size Commentary Version Access 10.1021acs.jmedchem.2c02097.pdf 1 5.7 MB Publisher’s postprint open-access - 2.0558330 - ÚOCHB 2023 RIV NL eng J - Journal Article
Voldřich, Jan - Matoušová, Marika - Šmídková, Markéta - Slavíková, Barbora - Chodounská, Hana - Kudová, Eva - Mertlíková-Kaiserová, Helena
Identification of N-methyl-D-aspartate receptor antagonists using the rat postnatal mixed cortical and hippocampal neurons.
European Journal of Pharmacology. Roč. 927, July (2022), č. článku 175056. ISSN 0014-2999. E-ISSN 1879-0712
R&D Projects: GA TA ČR(CZ) TN01000013
Institutional support: RVO:61388963
Keywords : NMDA receptors * primary neurons * iPSC * neurosteroids
OECD category: Biochemistry and molecular biology
Impact factor: 5, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.ejphar.2022.175056
Permanent Link: http://hdl.handle.net/11104/0332052 - 3.0519335 - ÚOCHB 2021 RIV GB eng J - Journal Article
Procházková, Eliška - Hřebabecký, Hubert - Dejmek, Milan - Šála, Michal - Šmídková, Markéta - Tloušťová, Eva - Zborníková, Eva - Eyer, Luděk - Růžek, Daniel - Nencka, Radim
Could 5′-N and S ProTide analogues work as prodrugs of antiviral agents?
Bioorganic and Medicinal Chemistry Letters. Roč. 30, č. 4 (2020), č. článku 126897. ISSN 0960-894X. E-ISSN 1464-3405
R&D Projects: GA MZd(CZ) NV16-34238A; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT LO1302
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : antiviral * nucleotide * prodrug * ProTide * HCV * 31P NMR spectroscopy
OECD category: Organic chemistry; Microbiology (BC-A)
Impact factor: 2.823, year: 2020
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0960894X19308753?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0304523 - 4.0505510 - ÚOCHB 2020 RIV GB eng J - Journal Article
Šmídková, Markéta - Hájek, Miroslav - Adla, Santosh Kumar - Slavíková, Barbora - Chodounská, Hana - Matoušová, Marika - Mertlíková-Kaiserová, Helena - Kudová, Eva
Screening of novel 3 alpha 5 beta-neurosteroids for neuroprotective activity against glutamate- or NMDA-induced excitotoxicity.
Journal of Steroid Biochemistry and Molecular Biology. Roč. 189, May (2019), s. 195-203. ISSN 0960-0760
R&D Projects: GA TA ČR(CZ) TE01020028; GA MŠMT LO1302; GA TA ČR(CZ) TN01000013
Institutional support: RVO:61388963
Keywords : neurosteroids * NMDAR * glutamate excitotoxicity * neuroprotection
OECD category: Biochemistry and molecular biology
Impact factor: 3.813, year: 2019
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/abs/pii/S0960076019300378?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0296991 - 5.0498559 - ÚOCHB 2019 RIV CH eng J - Journal Article
Adla, Santosh Kumar - Slavíková, Barbora - Chodounská, Hana - Vyklický, Vojtěch - Ladislav, Marek - Hubálková, Pavla - Krausová, Barbora - Smejkalová, Tereza - Nekardová, Michaela - Šmídková, Markéta - Monincová, Lenka - Souček, Radko - Vyklický ml., Ladislav - Kudová, Eva
Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif.
Frontiers in Pharmacology. Roč. 9, Nov 12 (2018), č. článku 1299. ISSN 1663-9812. E-ISSN 1663-9812
R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GBP208/12/G016; GA ČR(CZ) GA17-02300S; GA ČR(CZ) GJ16-03913Y; GA MZd(CZ) NV15-29370A; GA MŠMT LO1302; GA MŠMT(CZ) ED1.1.00/02.0109
Grant - others:AV ČR(CZ) MSM200111601
Program: Program na podporu mezinárodní spolupráce začínajících výzkumných pracovníků
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : neurosteroid * amide * NMDA receptor * plasma stability * structure-activity relationship
OECD category: Biochemistry and molecular biology
Impact factor: 3.845, year: 2018
https://www.frontiersin.org/articles/10.3389/fphar.2018.01299/full
Permanent Link: http://hdl.handle.net/11104/0291127 - 6.0493604 - ÚOCHB 2019 RIV DE eng J - Journal Article
Česnek, Michal - Skácel, Jan - Jansa, Petr - Dračínský, Martin - Šmídková, Markéta - Mertlíková-Kaiserová, Helena - Soto-Velasquez, M. - Watts, V. J. - Janeba, Zlatko
Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis.
ChemMedChem. Roč. 13, č. 17 (2018), s. 1779-1796. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA MV VG20102015046; GA ČR(CZ) GBP208/12/G016; GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : adefovir * adenylate cyclase * Bacillus anthracis * Bordetella pertussis * inhibitors
OECD category: Organic chemistry
Impact factor: 3.016, year: 2018
Permanent Link: http://hdl.handle.net/11104/0286939 - 7.0489553 - ÚOCHB 2019 RIV DE eng J - Journal Article
Frydrych, Jan - Skácel, Jan - Šmídková, Markéta - Mertlíková-Kaiserová, Helena - Dračínský, Martin - Gnanasekaran, Ramachandran - Lepšík, Martin - Soto-Velasquez, M. - Watts, V. J. - Janeba, Zlatko
Synthesis of alpha-Branched Acyclic Nucleoside Phosphonates as Potential Inhibitors of Bacterial Adenylate Cyclases.
ChemMedChem. Roč. 13, č. 2 (2018), s. 199-206. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA MV VG20102015046; GA ČR(CZ) GBP208/12/G016; GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * adenylate cyclase toxin * bisamidates * Bordetella pertussis * prodrugs
OECD category: Organic chemistry
Impact factor: 3.016, year: 2018
Permanent Link: http://hdl.handle.net/11104/0283953 - 8.0474432 - ÚOCHB 2018 RIV US eng J - Journal Article
Adla, Santosh Kumar - Slavíková, Barbora - Šmídková, Markéta - Tloušťová, Eva - Svoboda, Martin - Vyklický, Vojtěch - Krausová, Barbora - Hubálková, Pavla - Nekardová, Michaela - Holubová, Kristína - Valeš, Karel - Buděšínský, Miloš - Vyklický ml., Ladislav - Chodounská, Hana - Kudová, Eva
Physicochemical and biological properties of novel amide-based steroidal inhibitors of NMDA receptors.
Steroids. Roč. 117, Jan (2017), s. 52-61. ISSN 0039-128X. E-ISSN 1878-5867.
[Conference on Isoprenoids /23./. Minsk, 04.09.2016-07.09.2016]
R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GAP303/12/1464; GA MŠMT LO1302; GA MZd(CZ) NV15-29370A; GA ČR(CZ) GBP208/12/G016
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : neurosteroid * NMDA receptor * structure-activity relationship * amide * blood-brain-barrier permeability * Caco-2 assay
OECD category: Organic chemistry; Organic chemistry (FGU-C)
Impact factor: 2.523, year: 2017
Permanent Link: http://hdl.handle.net/11104/0271487 - 9.0467409 - ÚOCHB 2017 RIV DE eng J - Journal Article
Břehová, Petra - Šmídková, Markéta - Skácel, Jan - Dračínský, Martin - Mertlíková-Kaiserová, Helena - Velasquez, M. P. S. - Watts, V. J. - Janeba, Zlatko
Design and Synthesis of Fluorescent Acyclic Nucleoside Phosphonates as Potent Inhibitors of Bacterial Adenylate Cyclases.
ChemMedChem. Roč. 11, č. 22 (2016), s. 2534-2546. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA MV VG20102015046; GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : adenylate cyclase toxin * acyclic nucleoside phosphonates * anthranilic acid
Subject RIV: CC - Organic Chemistry
Impact factor: 3.225, year: 2016
Permanent Link: http://hdl.handle.net/11104/0265511 - 10.0465631 - ÚOCHB 2017 RIV NL eng J - Journal Article
Eyer, L. - Šmídková, Markéta - Nencka, Radim - Neča, J. - Kastl, T. - Palus, Martin - De Clercq, E. - Růžek, Daniel
Structure-activity relationships of nucleoside analogues for inhibition of tick-borne encephalitis virus.
Antiviral Research. Roč. 133, Sep (2016), s. 119-129. ISSN 0166-3542. E-ISSN 1872-9096
R&D Projects: GA MZd(CZ) NV16-34238A; GA ČR(CZ) GA16-20054S
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : structure-activity relationship * tick-borne encephalitis * nucleoside inhibitor * antiviral activity * cytotoxicity
Subject RIV: CC - Organic Chemistry; EE - Microbiology, Virology (BC-A)
Impact factor: 4.271, year: 2016
Permanent Link: http://hdl.handle.net/11104/0264094