Search results
- 1.0574898 - ÚOCHB 2024 RIV NL eng J - Journal Article
Misehe, Mbilo - Matoušová, Marika - Dvořáková, Alexandra - Hercík, Kamil - Škach, Kryštof - Chalupská, Dominika - Dejmek, Milan - Šála, Michal - Hájek, Miroslav - Bouřa, Evžen - Mertlíková-Kaiserová, Helena - Nencka, Radim
Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases.
European Journal of Medicinal Chemistry. Roč. 260, November (2023), č. článku 115717. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) LX22NPO5103; GA MZd(CZ) NU20-05-00472
Institutional support: RVO:61388963
Keywords : kinase inhibitor * quinazoline derivatives * RIPK2 * NOD * inflammation * RIPK3
OECD category: Medicinal chemistry
Impact factor: 6.7, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.ejmech.2023.115717
Permanent Link: https://hdl.handle.net/11104/0344824File Download Size Commentary Version Access 10.1016j.ejmech.2023.115717.pdf 0 4.4 MB Publisher’s postprint open-access - 2.0574366 - ÚOCHB 2024 RIV US eng J - Journal Article
Břehová, Petra - Řezníčková, E. - Škach, Kryštof - Jorda, R. - Dejmek, Milan - Vojáčková, V. - Šála, Michal - Kovalová, M. - Dračínský, Martin - Dolníková, A. - Strmeň, Timotej - Kinnertová, M. - Chalupský, Karel - Dvořáková, Alexandra - Gucký, T. - Mertlíková-Kaiserová, Helena - Klener, P. - Nencka, Radim - Kryštof, V.
Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping.
Journal of Medicinal Chemistry. Roč. 66, č. 16 (2023), s. 11133-11157. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MZd(CZ) NU20-05-00472; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : gene expression * highly potent
OECD category: Oncology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.3c00575
Permanent Link: https://hdl.handle.net/11104/0344703File Download Size Commentary Version Access 10.1021acs.jmedchem.3c00575.pdf 0 7.8 MB Publisher’s postprint open-access - 3.0574244 - ÚOCHB 2024 RIV US eng J - Journal Article
Štefek, Milan - Chalupská, Dominika - Chalupský, Karel - Zgarbová, Michala - Dvořáková, Alexandra - Krafčíková, Petra - Li, A. S. M. - Šála, Michal - Dejmek, Milan - Otava, Tomáš - Chaloupecká, Ema - Kozák, Jaroslav - Kozic, Ján - Vedadi, M. - Weber, Jan - Mertlíková-Kaiserová, Helena - Nencka, Radim
Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors.
ACS Omega. Roč. 8, č. 30 (2023), s. 27410-27418. ISSN 2470-1343. E-ISSN 2470-1343
R&D Projects: GA MZd(CZ) NU20-05-00472; GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963
Keywords : SARS-CoV-2 * genetics * inhibitors
OECD category: Virology
Impact factor: 4.1, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acsomega.3c02815
Permanent Link: https://hdl.handle.net/11104/0344580File Download Size Commentary Version Access acsomega.3c02815 (2).pdf 0 5.1 MB Publisher’s postprint open-access - 4.0573725 - ÚOCHB 2024 RIV US eng J - Journal Article
Šlachtová, Veronika - Bellová, Simona - La-Venia, A. - Galeta, Juraj - Dračínský, Martin - Chalupský, Karel - Dvořáková, Alexandra - Mertlíková-Kaiserová, Helena - Rukovanský, P. - Dzijak, Rastislav - Vrábel, Milan
Triazinium Ligation: Bioorthogonal Reaction of N1-Alkyl 1,2,4-Triazinium Salts.
Angewandte Chemie - International Edition. Roč. 62, č. 36 (2023), č. článku e202306828. ISSN 1433-7851. E-ISSN 1521-3773
R&D Projects: GA ČR(CZ) GF20-30494L; GA MŠMT(CZ) LX22NPO5104
Institutional support: RVO:61388963
Keywords : bioimaging * click reaction * protein labeling * proteins * triazines
OECD category: Organic chemistry
Impact factor: 16.6, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/anie.202306828
Permanent Link: https://hdl.handle.net/11104/0344107File Download Size Commentary Version Access 10.1002anie.202306828.pdf 1 1.7 MB Publisher’s postprint open-access - 5.0572565 - ÚOCHB 2024 RIV US eng J - Journal Article
Skácel, Jan - Djukic, Stefan - Baszczyňski, Ondřej - Kalčic, Filip - Bílek, Tadeáš - Chalupský, Karel - Kozák, Jaroslav - Dvořáková, Alexandra - Tloušťová, Eva - Kráľová, Zuzana - Šmídková, Markéta - Voldřich, Jan - Rumlová, M. - Pachl, Petr - Brynda, Jiří - Vučková, Tereza - Fábry, Milan - Snášel, Jan - Pichová, Iva - Řezáčová, Pavlína - Mertlíková-Kaiserová, Helena - Janeba, Zlatko
Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors.
Journal of Medicinal Chemistry. Roč. 66, č. 10 (2023), s. 6652-6681. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA TA ČR(CZ) TN01000013; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : multisubstrate analog inhibitors * transition-state analog * human erythrocytes
OECD category: Organic chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.2c02097
Permanent Link: https://hdl.handle.net/11104/0343213File Download Size Commentary Version Access 10.1021acs.jmedchem.2c02097.pdf 1 5.7 MB Publisher’s postprint open-access - 6.0547506 - ÚOCHB 2022 RIV US eng J - Journal Article
Kalčic, Filip - Zgarbová, Michala - Hodek, Jan - Chalupský, Karel - Dračínský, Martin - Dvořáková, Alexandra - Strmeň, Timotej - Šebestík, Jaroslav - Baszczyňski, Ondřej - Weber, Jan - Mertlíková-Kaiserová, Helena - Janeba, Zlatko
Discovery of Modified Amidate (ProTide) Prodrugs of Tenofovir with Enhanced Antiviral Properties.
Journal of Medicinal Chemistry. Roč. 64, č. 22 (2021), s. 16425-16449. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT LTAUSA18086
Institutional support: RVO:61388963
Keywords : chemistry * drug development * drug effect
OECD category: Organic chemistry
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c01444
Permanent Link: http://hdl.handle.net/11104/0323727 - 7.0427655 - ÚOCHB 2015 RIV US eng J - Journal Article
Šmídková, Markéta - Dvořáková, Alexandra - Tloušťová, Eva - Česnek, Michal - Janeba, Zlatko - Mertlíková-Kaiserová, Helena
Amidate Prodrugs of 9-[2-(Phosphonomethoxy)Ethyl]Adenine as Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis.
Antimicrobial Agents and Chemotherapy. Roč. 58, č. 2 (2014), s. 664-671. ISSN 0066-4804. E-ISSN 1098-6596
R&D Projects: GA MV VG20102015046
Grant - others:OPPC(XE) CZ.2.16/3.1.00/24016
Institutional support: RVO:61388963
Keywords : Bordetella pertussis * adenylate cyclase toxin * ACT * inhibitors * PMEA * amidate prodrugs
Subject RIV: CC - Organic Chemistry
Impact factor: 4.476, year: 2014
Permanent Link: http://hdl.handle.net/11104/0233171 - 8.0396057 - ÚOCHB 2014 RIV GR eng J - Journal Article
Plačková, Pavla - Rozumová, N. - Hřebabecký, Hubert - Šála, Michal - Nencka, Radim - Elbert, Tomáš - Dvořáková, Alexandra - Votruba, Ivan - Mertlíková-Kaiserová, Helena
9-Norbornyl-6-chloropurine Is a Novel Antileukemic Compound Interacting with Cellular GSH.
Anticancer Research. Roč. 33, č. 8 (2013), s. 3163-3168. ISSN 0250-7005. E-ISSN 1791-7530
R&D Projects: GA ČR GAP303/11/1297
Institutional support: RVO:61388963
Keywords : Substituted 6-chloropurines * carbocyclic nucleoside analogs * glutathione-S-transferase * glutathione depletion
Subject RIV: FD - Oncology ; Hematology
Impact factor: 1.872, year: 2013
Permanent Link: http://hdl.handle.net/11104/0223911 - 9.0369214 - ÚOCHB 2012 RIV CZ eng J - Journal Article
Jansa, Petr - Kolman, Viktor - Kostinová, Alexandra - Dračínský, Martin - Mertlíková-Kaiserová, Helena - Janeba, Zlatko
Efficient synthesis and biological properties of the 2‘-trifluoromethyl analogues of acyclic nucleosides and acyclic nucleoside phosphonates.
Collection of Czechoslovak Chemical Communications. Roč. 76, č. 10 (2011), s. 1187-1198. ISSN 0010-0765
R&D Projects: GA MV VG20102015046
Institutional research plan: CEZ:AV0Z40550506
Keywords : nucleosides * nucleotides * phosphorus * fluorine * biological activity * antibiotics
Subject RIV: CC - Organic Chemistry
Impact factor: 1.283, year: 2011
Permanent Link: http://hdl.handle.net/11104/0203334