Search results
- 1.0568174 - ÚOCHB 2024 RIV US eng J - Journal Article
Prener, Ladislav - Baszczyňski, Ondřej - Kaiser, Martin Maxmilian - Dračínský, Martin - Stepan, G. - Lee, Y. J. - Brumshtein, B. - Yu, H. - Jansa, P. - Lansdon, E. B. - Janeba, Zlatko
Design and Synthesis of Novel HIV-1 NNRTIs with Bicyclic Cores and with Improved Physicochemical Properties.
Journal of Medicinal Chemistry. Roč. 66, č. 3 (2023), s. 1761-1777. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:61388963
Keywords : reverse transcriptase inhibitors * wild type * optimization
OECD category: Organic chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.2c01574
Permanent Link: https://hdl.handle.net/11104/0339509 - 2.0518189 - ÚOCHB 2020 RIV GB eng J - Journal Article
Čechová, Lucie - Dejmek, Milan - Baszczyňski, Ondřej - Šaman, David - Gao, L. - Hu, E. - Stepan, G. - Jansa, P. - Janeba, Zlatko - Šimon, Petr
Synthesis and anti-human immunodeficiency virus activity of substituted (o,o-difluorophenyl)-linked-pyrimidines as potent non‐nucleoside reverse transcriptase inhibitors.
Antiviral Chemistry and Chemotherapy. Roč. 27, Feb 6 (2019), s. 1-18. ISSN 0956-3202
Institutional support: RVO:61388963
Keywords : diarylpyrimidine * human immunodeficiency virus * non-nucleoside reverse transcriptase inhibitor * etravirine * rilpivirine
OECD category: Organic chemistry
Method of publishing: Open access
https://journals.sagepub.com/doi/full/10.1177/2040206619826265
Permanent Link: http://hdl.handle.net/11104/0303424 - 3.0464300 - ÚOCHB 2017 RIV FR eng J - Journal Article
Šimon, Petr - Baszczyňski, Ondřej - Šaman, David - Stepan, G. - Hu, E. - Lansdon, E. B. - Jansa, P. - Janeba, Zlatko
Novel (2,6-difluorophenyl)(2-(phenylamino)pyrimidin-4-yl) methanones with restricted conformation as potent non-nucleoside reverse transcriptase inhibitors against HIV-1.
European Journal of Medicinal Chemistry. Roč. 122, Oct 21 (2016), s. 185-195. ISSN 0223-5234. E-ISSN 1768-3254
Institutional support: RVO:61388963
Keywords : diarylpyrimidine (DAPY) * etravirine * human immunodeficiency virus (HIV) * non-nucleoside reverse transcriptase inhibitors * NNRTIs * rilpivirine
Subject RIV: CC - Organic Chemistry
Impact factor: 4.519, year: 2016
Permanent Link: http://hdl.handle.net/11104/0263235 - 4.0391954 - ÚOCHB 2014 RIV GB eng J - Journal Article
Krečmerová, Marcela - Jansa, Petr - Dračínský, Martin - Sázelová, Petra - Kašička, Václav - Neyts, J. - Auwerx, J. - Kiss, E. - Goris, N. - Stepan, G. - Janeba, Zlatko
9-[2-(R)-(Phosphonomethoxy)propyl]-2,6-diaminopurine (R)-PMPDAP and its prodrugs: Optimized preparation, including identification of by-products formed, and antiviral evaluation in vitro.
Bioorganic & Medicinal Chemistry. Roč. 21, č. 5 (2013), s. 1199-1208. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT(CZ) ME10040
Institutional support: RVO:61388963
Keywords : PMPDAP * Acyclic nucleoside phosphonates * (Phosphonomethoxy)propyl * purine * antivirals * HIV
Subject RIV: CC - Organic Chemistry
Impact factor: 2.951, year: 2013
Permanent Link: http://hdl.handle.net/11104/0220970 - 5.0363152 - ÚOCHB 2012 RIV FR eng J - Journal Article
Jansa, Petr - Baszczyňski, Ondřej - Dračínský, Martin - Votruba, Ivan - Zídek, Zdeněk - Bahador, G. - Stepan, G. - Cihlar, T. - Mackman, R. - Holý, Antonín - Janeba, Zlatko
A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities.
European Journal of Medicinal Chemistry. Roč. 46, č. 9 (2011), s. 3748-3754. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MV VG20102015046
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50390703
Keywords : prodrugs * phosphonodiamides * bis-amidates * acyclic nucleoside phosphonates * GS-9219
Subject RIV: CC - Organic Chemistry
Impact factor: 3.346, year: 2011
Permanent Link: http://hdl.handle.net/11104/0199212