Search results
- 1.0543665 - ÚOCHB 2022 RIV DE eng J - Journal Article
Kalčic, Filip - Kolman, Viktor - Zídek, Zdeněk - Janeba, Zlatko
Polysubstituted Pyrimidines as Potent Inhibitors of Prostaglandin E2 Production: Increasing Aqueous Solubility.
ChemMedChem. Roč. 16, č. 18 (2021), s. 2802-2806. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : anti-inflammatory * prostaglandin E2 * pyrimidines * solubility * synthesis
OECD category: Organic chemistry; Medicinal chemistry (UEM-P)
Impact factor: 3.540, year: 2021
Method of publishing: Limited access
https://doi.org/10.1002/cmdc.202100263
Permanent Link: http://hdl.handle.net/11104/0320847 - 2.0533528 - ÚOCHB 2021 RIV US eng J - Journal Article
Dosoudil, P. - Kotek, V. - Kolman, Viktor - Baszczyňski, Ondřej - Kaiser, Martin Maxmilian - Janeba, Zlatko - Havránek, M.
Development of Scalable Synthesis of 5-Butyl-4-(4-methoxyphenyl)-6-phenylpyrimidin-2-amine (WQE-134), a Dual Inhibitor of Nitric Oxide and Prostaglandin E2 Production.
Organic Process Research & Development. Roč. 24, č. 9 (2020), s. 1718-1724. ISSN 1083-6160. E-ISSN 1520-586X
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963
Keywords : pyrimidines * Eaton’s reagent * upscale * C-acylation
OECD category: Organic chemistry
Impact factor: 3.317, year: 2020
Method of publishing: Limited access
https://doi.org/10.1021/acs.oprd.0c00324
Permanent Link: http://hdl.handle.net/11104/0312366 - 3.0525593 - ÚOCHB 2021 RIV DE eng J - Journal Article
Kalčic, Filip - Kolman, Viktor - Ajani, Haresh - Zídek, Zdeněk - Janeba, Zlatko
Polysubstituted Pyrimidines as mPGES‐1 Inhibitors: Discovery of Potent Inhibitors of PGE2 Production with Strong Anti‐inflammatory Effects in Carrageenan‐Induced Rat Paw Edema.
ChemMedChem. Roč. 15, č. 15 (2020), s. 1398-1407. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : anti-inflammatory * mPGES-1 * prostaglandin E2 * pyrimidines * Suzuki Miyaura reaction
OECD category: Organic chemistry; Medicinal chemistry (UEM-P)
Impact factor: 3.466, year: 2020
Method of publishing: Limited access
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cmdc.202000258
Permanent Link: http://hdl.handle.net/11104/0309705 - 4.0493581 - ÚOCHB 2019 RIV FR eng J - Journal Article
Kolman, Viktor - Kalčic, Filip - Jansa, Petr - Zídek, Zdeněk - Janeba, Zlatko
Influence of the C-5 substitution in polysubstituted pyrimidines on inhibition of prostaglandin E2 production.
European Journal of Medicinal Chemistry. Roč. 156, Aug 5 (2018), s. 295-301. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : pyrimidines * Suzuki-Miyaura reaction * prostaglandin E2 * inhibitor
OECD category: Organic chemistry; Medicinal chemistry (UEM-P)
Impact factor: 4.833, year: 2018
Permanent Link: http://hdl.handle.net/11104/0286924 - 5.0476117 - ÚOCHB 2018 RIV NL eng J - Journal Article
Kolman, Viktor - Jansa, Petr - Kalčic, Filip - Janeba, Zlatko - Zídek, Zdeněk
Polysubstituted 4,6-bis(hetero)arylpyrimidines as dual inhibitors of nitric oxide and prostaglandin E-2 production.
Nitric Oxide-Biology and Chemistry. Roč. 67, Jul 1 (2017), s. 53-57. ISSN 1089-8603. E-ISSN 1089-8611
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : pyrimidine derivatives * nitric oxide * prostaglandin E-2 * dual inhibitors * anti-inflammatory properties
OECD category: Biochemistry and molecular biology; Organic chemistry (UEM-P)
Impact factor: 4.367, year: 2017
Permanent Link: http://hdl.handle.net/11104/0272652 - 6.0444646 - ÚOCHB 2016 RIV US eng J - Journal Article
Jansa, Petr - Holý, Antonín - Dračínský, Martin - Kolman, Viktor - Janeba, Zlatko - Kmoníčková, Eva - Zídek, Zdeněk
Synthesis and structure-activity relationship studies of polysubstituted pyrimidines as inhibitors of immune-activated nitric oxide production.
Medicinal Chemistry Research. Roč. 24, č. 5 (2015), s. 2154-2166. ISSN 1054-2523. E-ISSN 1554-8120
R&D Projects: GA ČR(CZ) GAP303/12/0172; GA MV VG20102015046
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : pyrimidine * nitric oxide * NO * anti-inflammatory
Subject RIV: CC - Organic Chemistry
Impact factor: 1.436, year: 2015
Permanent Link: http://hdl.handle.net/11104/0247170 - 7.0432303 - ÚOCHB 2015 RIV US eng J - Journal Article
Jansa, Petr - Holý, Antonín - Dračínský, Martin - Kolman, Viktor - Janeba, Zlatko - Kostecká, Petra - Kmoníčková, Eva - Zídek, Zdeněk
5-Substituted 2-amino-4,6-dihydroxypyrimidines and 2-amino-4,6-dichloropyrimidines: synthesis and inhibitory effects on immune-activated nitric oxide production.
Medicinal Chemistry Research. Roč. 23, č. 10 (2014), s. 4482-4490. ISSN 1054-2523. E-ISSN 1554-8120
R&D Projects: GA ČR(CZ) GAP303/12/0172
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : pyrimidine * nitric oxide * NO * anti-inflammatory
Subject RIV: CC - Organic Chemistry; FR - Pharmacology ; Medidal Chemistry (UEM-P)
Impact factor: 1.402, year: 2014
Permanent Link: http://hdl.handle.net/11104/0236738 - 8.0369214 - ÚOCHB 2012 RIV CZ eng J - Journal Article
Jansa, Petr - Kolman, Viktor - Kostinová, Alexandra - Dračínský, Martin - Mertlíková-Kaiserová, Helena - Janeba, Zlatko
Efficient synthesis and biological properties of the 2‘-trifluoromethyl analogues of acyclic nucleosides and acyclic nucleoside phosphonates.
Collection of Czechoslovak Chemical Communications. Roč. 76, č. 10 (2011), s. 1187-1198. ISSN 0010-0765
R&D Projects: GA MV VG20102015046
Institutional research plan: CEZ:AV0Z40550506
Keywords : nucleosides * nucleotides * phosphorus * fluorine * biological activity * antibiotics
Subject RIV: CC - Organic Chemistry
Impact factor: 1.283, year: 2011
Permanent Link: http://hdl.handle.net/11104/0203334