Search results
- 1.0576583 - BFÚ 2024 RIV DE eng J - Journal Article
Prachařová, J. - Kostrhunová, Hana - Barbanente, A. - Margiotta, N. - Brabec, Viktor
The mechanism of antiproliferative activity of the oxaliplatin pyrophosphate derivative involves its binding to nuclear DNA in cancer cells.
Journal of Biological Inorganic Chemistry. Roč. 28, č. 7 (2023), s. 669-678. ISSN 0949-8257. E-ISSN 1432-1327
R&D Projects: GA ČR(CZ) GA21-27514S
Institutional support: RVO:68081707
Keywords : Phosphaplatin * Cisplatin * Oxaliplatin * Anticancer * dna * Mechanism of action
OECD category: Biochemistry and molecular biology
Impact factor: 3, year: 2022
Method of publishing: Limited access
https://link.springer.com/article/10.1007/s00775-023-02017-x
Permanent Link: https://hdl.handle.net/11104/0349242 - 2.0558795 - BFÚ 2023 RIV GB eng J - Journal Article
Novohradský, Vojtěch - Marková, Lenka - Kostrhunová, Hana - Svitelova, M. - Kašpárková, Jana - Barbanente, A. - Papadia, p. - Margiotta, N. - Hoeschele, J. D. - Brabec, Viktor
Pt(II) complex containing the 1R,2R enantiomer of trans-1,2-diamino-4-cyclohexene ligand effectively and selectively inhibits the viability of aggressive pancreatic adenocarcinoma cells and alters their lipid metabolism.
Inorganic Chemistry Frontiers. Roč. 9, č. 13 (2022), s. 3295-3305. ISSN 2052-1553. E-ISSN 2052-1553
R&D Projects: GA MŠMT(CZ) LTAUSA18009
Institutional support: RVO:68081707
Keywords : cancer-cells * er stress * lipogenesis * droplets * agents * proteins * accumulation
OECD category: Cell biology
Impact factor: 7, year: 2022
Method of publishing: Limited access
https://pubs.rsc.org/en/content/articlelanding/2022/QI/D2QI00778A
Permanent Link: https://hdl.handle.net/11104/0340483 - 3.0486058 - BFÚ 2018 RIV GB eng J - Journal Article
Kašpárková, Jana - Kostrhunová, Hana - Novohradský, Vojtěch - Prachařová, J. - Curcio, A. - Margiotta, N. - Natile, G. - Brabec, Viktor
Anticancer kiteplatin pyrophosphate derivatives show unexpected target selectivity for DNA.
Dalton Transactions. Roč. 46, č. 41 (2017), s. 14139-14148. ISSN 1477-9226. E-ISSN 1477-9234
R&D Projects: GA ČR(CZ) GA17-05302S
Institutional support: RVO:68081707
Keywords : cancer-chemotherapy * platinum complexes * cross-links
OECD category: Biochemistry and molecular biology
Impact factor: 4.099, year: 2017
Permanent Link: http://hdl.handle.net/11104/0281991 - 4.0386041 - BFÚ 2013 RIV DE eng J - Journal Article
Brabec, Viktor - Malina, Jaroslav - Margiotta, N. - Natile, G. - Kašpárková, Jana
Thermodynamic and mechanistic insights into translesion DNA synthesis catalyzed by Y-family DNA polymerase across a bulky double-base lesion of an antitumor platinum drug.
Chemistry - A European Journal. Roč. 18, č. 48 (2012), s. 15439-15448. ISSN 0947-6539. E-ISSN 1521-3765
R&D Projects: GA ČR(CZ) GAP205/11/0856; GA ČR(CZ) GAP301/10/0598
Institutional research plan: CEZ:AV0Z50040702
Keywords : DNA polymerase * platinum * calorimetry
Subject RIV: BO - Biophysics
Impact factor: 5.831, year: 2012
Permanent Link: http://hdl.handle.net/11104/0220146 - 5.0373400 - BFÚ 2012 RIV US eng J - Journal Article
Kašpárková, Jana - Suchánková, T. - Halámiková, Anna - Zerzánková, Lenka - Vrána, Oldřich - Margiotta, N. - Natile, G. - Brabec, Viktor
Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring PtII chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand.
Biochemical Pharmacology. Roč. 79, č. 4 (2010), s. 552-564. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA MŠMT(CZ) LC06030; GA AV ČR(CZ) KAN200200651
Keywords : DNA * platinum * cancer
Subject RIV: BO - Biophysics
Impact factor: 4.889, year: 2010
Permanent Link: http://hdl.handle.net/11104/0206508 - 6.0347184 - BFÚ 2011 RIV US eng J - Journal Article
Kašpárková, Jana - Suchánková, T. - Halámiková, Anna - Zerzánková, Lenka - Vrána, Oldřich - Margiotta, N. - Natile, G. - Brabec, Viktor
Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring PtII chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand.
Biochemical Pharmacology. Roč. 79, č. 4 (2010), s. 552-564. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA MŠMT(CZ) LC06030; GA MŠMT(CZ) ME08017; GA MŠMT(CZ) OC08003; GA AV ČR(CZ) 1QS500040581; GA AV ČR(CZ) KAN200200651; GA AV ČR(CZ) IAA400040803; GA AV ČR(CZ) GD301/09/H004
Grant - others:GA MŠk(CZ) OC09018
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : DNA * platinum * cancer
Subject RIV: BO - Biophysics
Impact factor: 4.889, year: 2010
Permanent Link: http://hdl.handle.net/11104/0188017