Search results
- 1.0585313 - ÚMG 2025 RIV US eng J - Journal Article
Andronikou, C. - Burdová, Kamila - Dibitetto, D. - Lieftink, C. - Malzer, E. - Kuiken, H. J. - Gogola, E. - Chaudhuri, A. R. - Beijersbergen, R. L. - Hanzlíková, Hana - Jonkers, J. - Rottenberg, S.
PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair.
EMBO Journal. Roč. 43, č. 6 (2024), s. 1015-1042. ISSN 0261-4189. E-ISSN 1460-2075
R&D Projects: GA ČR GA22-00885S
Institutional support: RVO:68378050
Keywords : tumor cells * PARG * DNA Repair * BRCA2
OECD category: Cell biology
Impact factor: 11.4, year: 2022
Method of publishing: Open access
https://www.embopress.org/doi/full/10.1038/s44318-024-00043-2
Permanent Link: https://hdl.handle.net/11104/0353023 - 2.0566109 - ÚMG 2023 RIV GB eng J - Journal Article
Cihlářová, Zuzana - Kubovčiak, Jan - Sobol, Margaryta - Krejčíková, Kateřina - Šáchová, Jana - Kolář, Michal - Staněk, David - Bařinka, Cyril - Yoon, G. - Caldecott, Keith - Hanzlíková, Hana
BRAT1 links Integrator and defective RNA processing with neurodegeneration.
Nature Communications. Roč. 13, č. 1 (2022), č. článku 5026. E-ISSN 2041-1723
R&D Projects: GA ČR GA22-00885S; GA ČR GA21-04132S; GA MŠMT(CZ) EF16_019/0000785; GA MŠMT(CZ) LM2018129; GA MŠMT(CZ) EF18_046/0016045; GA MŠMT(CZ) ED1.1.00/02.0109
Research Infrastructure: Czech-BioImaging II - 90129
Institutional support: RVO:68378050 ; RVO:86652036
Keywords : Multifocal seizure syndromelethal * Lethal neonatal regidity * Histone messenger-RNAS * Transcription * Complex * Association * Disruption * Mutation
OECD category: Cell biology; Cell biology (BTO-N)
Impact factor: 16.6, year: 2022
Method of publishing: Open access
https://www.nature.com/articles/s41467-022-32763-6
Permanent Link: https://hdl.handle.net/11104/0337543 - 3.0565988 - ÚMG 2023 RIV US eng J - Journal Article
Vaitsiankova, A. - Burdova, K. - Sobol, Margaryta - Gautam, A. - Benada, Oldřich - Hanzlíková, Hana - Caldecott, Keith
PARP inhibition impedes the maturation of nascent DNA strands during DNA replication.
Nature Structural & Molecular Biology. Roč. 29, č. 4 (2022), s. 329-351. ISSN 1545-9993. E-ISSN 1545-9985
R&D Projects: GA MŠMT(CZ) LM2018129; GA MŠMT(CZ) EF18_046/0016045; GA MŠMT(CZ) EF16_013/0001775
Research Infrastructure: Czech-BioImaging II - 90129
Institutional support: RVO:68378050 ; RVO:61388971
Keywords : Homologous recombination * Synthetic lethality * Okazaki fragments * Fork progression * Cells * Repair * Damage * Endonuclease * Mechanism * Restart
OECD category: Biochemistry and molecular biology; Biochemistry and molecular biology (MBU-M)
Impact factor: 16.8, year: 2022
Method of publishing: Open access
https://www.nature.com/articles/s41594-022-00747-1
Permanent Link: https://hdl.handle.net/11104/0337428 - 4.0554292 - ÚMG 2022 RIV DE eng J - Journal Article
Adamowicz, M. - Hailstone, R. - Demin, A.A. - Komulainen, E. - Hanzlíková, Hana - Brazina, J. - Gautam, A. - Wells, S. - Caldecott, Keith
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair.
Nature Cell Biology. Roč. 23, č. 12 (2021), s. 1287-1298. ISSN 1465-7392. E-ISSN 1476-4679
Institutional support: RVO:68378050
Keywords : rna-polymerase-ii * single-strand breaks * histone h2b ubiquitylation * poly(adp-ribose) polymerase * adp-ribosylation * dependent monoubiquitylation * chromatin-structure * cellular-response * terminal domain * human homolog
OECD category: Cell biology
Impact factor: 28.213, year: 2021
Method of publishing: Open access
https://www.nature.com/articles/s41556-021-00792-w
Permanent Link: http://hdl.handle.net/11104/0328927 - 5.0544978 - ÚMG 2022 RIV GB eng J - Journal Article
Wu, W. - Hill, S.E. - Nathan, W.J. - Paiano, J. - Callen, E. - Wang, D. - Shinoda, K. - van Wietmarschen, N. - Colon-Mercado, J.M. - Zong, D. - De Pace, R. - Shih, H.Y. - Coon, S. - Parsadanian, M. - Pavani, R. - Hanzlíková, Hana - Park, S. - Jung, S.K. - McHugh, P.J. - Canela, A. - Chen, C. - Casellas, R. - Caldecott, Keith - Ward, M.E. - Nussenzweig, A.
Neuronal enhancers are hotspots for DNA single-strand break repair.
Nature. Roč. 593, č. 7859 (2021), s. 440-444. ISSN 0028-0836. E-ISSN 1476-4687
Institutional support: RVO:68378050
Keywords : pluripotent stem-cells * human genome * chromatin * binding * wide * gene * 5-hydroxymethylcytosine * differentiation * identification * annotation
OECD category: Cell biology
Impact factor: 69.504, year: 2021
Method of publishing: Limited access
https://www.nature.com/articles/s41586-021-03468-5
Permanent Link: http://hdl.handle.net/11104/0321766 - 6.0544973 - ÚMG 2022 RIV US eng J - Journal Article
Komulainen, E. - Badman, J. - Rey, S. - Rulten, S. - Ju, L. - Fennell, K. - Kalasová, Ilona - Ilievová, Kristýna - McKinnon, P.J. - Hanzlíková, Hana - Staras, K. - Caldecott, Keith
Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures.
Embo Reports. Roč. 22, č. 5 (2021), č. článku e51851. ISSN 1469-221X. E-ISSN 1469-3178
Institutional support: RVO:68378050
Keywords : DNA strand break * neurodegeneration * poly(ADP‐ * ribose) polymerase * seizures * xrcc1
OECD category: Biochemistry and molecular biology
Impact factor: 9.421, year: 2021
Method of publishing: Open access
https://www.embopress.org/doi/full/10.15252/embr.202051851
Permanent Link: http://hdl.handle.net/11104/0321763 - 7.0544972 - ÚMG 2022 RIV US eng J - Journal Article
Demin, A.A. - Hirota, K. - Tsuda, M. - Adamowicz, M. - Hailstone, R. - Brazina, J. - Gittens, W. - Kalasová, Ilona - Shao, Z. - Zha, S. - Sasanuma, H. - Hanzlíková, Hana - Takeda, S. - Caldecott, Keith
XRCC1 prevents toxic PARP1 trapping during DNA base excision repair.
Molecular Cell. Roč. 81, č. 14 (2021), s. 3018-3030. ISSN 1097-2765. E-ISSN 1097-4164
Institutional support: RVO:68378050
Keywords : strand-break repair * polymerase-beta * poly(adp-ribose) polymerase * polynucleotide kinase * ligase iii * molecular-cloning * adp-ribosylation * protein xrcc1 * brct domain * damage
OECD category: Biochemistry and molecular biology
Impact factor: 19.328, year: 2021
Method of publishing: Open access
https://www.cell.com/molecular-cell/fulltext/S1097-2765(21)00366-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS109727652100366X%3Fshowall%3Dtrue
Permanent Link: http://hdl.handle.net/11104/0321762 - 8.0540318 - ÚMG 2021 RIV GB eng J - Journal Article
Kalasová, Ilona - Hailstone, R. - Bublitz, J. - Bogantes, J. - Hofmann, W. - Leal, A. - Hanzlíková, Hana - Caldecott, Keith
Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair.
Nucleic Acids Research. Roč. 48, č. 12 (2020), s. 6672-6684. ISSN 0305-1048. E-ISSN 1362-4962
R&D Projects: GA MŠMT(CZ) LM2015062; GA MŠMT(CZ) EF16_013/0001775; GA MŠMT LO1419
Institutional support: RVO:68378050
Keywords : PNKP * DNA single-strand break repair * neurologic disease PNKP
OECD category: Cell biology
Impact factor: 16.971, year: 2020
Method of publishing: Open access
https://academic.oup.com/nar/article/48/12/6672/5854143
Permanent Link: http://hdl.handle.net/11104/0317958 - 9.0535767 - ÚMG 2021 RIV GB eng J - Journal Article
Giovannini, S. - Weller, M. Ch. - Hanzlíková, Hana - Shiota, T. - Takeda, S. - Jiricny, J.
ATAD5 deficiency alters DNA damage metabolism and sensitizes cells to PARP inhibition.
Nucleic Acids Research. Roč. 48, č. 9 (2020), s. 4928-4939. ISSN 0305-1048. E-ISSN 1362-4962
Institutional support: RVO:68378050
Keywords : alternative rfc complex * c-like complex * saccharomyces-cerevisiae * genome-wide * human elg1 * replication * pcna * repair * clamp * mechanism
OECD category: Cell biology
Impact factor: 16.971, year: 2020
Method of publishing: Open access
https://academic.oup.com/nar/article/48/9/4928/5820885
Permanent Link: http://hdl.handle.net/11104/0313705 - 10.0531327 - ÚMG 2021 RIV GB eng J - Journal Article
Hanzlíková, Hana - Prokhorova, E. - Krejčíková, Kateřina - Cihlářová, Zuzana - Kalasová, Ilona - Kubovčiak, Jan - Šáchová, Jana - Hailstone, R. - Brazina, J. - Ghosh, S. - Cirak, S. - Gleeson, J. G. - Ahel, I. - Caldecott, Keith
Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair.
Nature Communications. Roč. 11, č. 1 (2020), č. článku 3391. E-ISSN 2041-1723
R&D Projects: GA MŠMT(CZ) LM2015062; GA MŠMT(CZ) EF16_013/0001775; GA MŠMT LO1419; GA TA ČR TE02000058
Institutional support: RVO:68378050
Keywords : poly(adp-ribose) glycohydrolase * xrcc1 * binding * identification * ribosylation * degradation * specificity * serine * ataxia * roles
OECD category: Cell biology
Impact factor: 14.919, year: 2020
Method of publishing: Open access
https://www.nature.com/articles/s41467-020-17069-9
Permanent Link: http://hdl.handle.net/11104/0310004