Search results
- 1.0578936 - MBÚ 2024 RIV US eng J - Journal Article
Wu, Y. - Du, S. - Bimler, Lynn H. - Mauk, K. E. - Lortal, L. - Kichik, N. - Griffiths, J. S. - Osička, Radim - Song, L. - Polsky, K. - Kasper, L. - Šebo, Peter - Weatherhead, J. - Knight, J. M. - Kheradmand, F. - Zheng, H. - Richardson, J. P. - Hube, B. - Naglik, J. R. - Corry, D. B.
Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis.
Cell Reports. Roč. 42, č. 10 (2023), č. článku 113240. ISSN 2211-1247. E-ISSN 2211-1247
R&D Projects: GA MŠMT(CZ) LM2023053
Institutional support: RVO:61388971
Keywords : secreted aspartic proteinases * central-nervous-system * allergic responses * fungal-infection * brain * tissue * identification * recognition * astrocytes * generation
OECD category: Microbiology
Impact factor: 8.8, year: 2022
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S2211124723012524?via%3Dihub
Permanent Link: https://hdl.handle.net/11104/0347845 - 2.0578510 - ÚOCHB 2024 RIV US eng J - Journal Article
Novotná, Kateřina - Tenora, Lukáš - Prchalová, E. - Paule, J. - Alt, J. - Veeravalli, V. - Lam, J. - Wu, Y. - Šnajdr, Ivan - Gori, S. - Mettu, V. S. - Tsukamoto, T. - Majer, Pavel - Slusher, B. S. - Rais, R.
Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-L-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery.
Journal of Medicinal Chemistry. Roč. 66, č. 22 (2023), s. 15493-15510. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT LTAUSA18166; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : phase-I * 6-diazo-5-oxo-l-norleucine DON * clinical pharmacology
OECD category: Organic chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01681
Permanent Link: https://hdl.handle.net/11104/0347498File Download Size Commentary Version Access 10.1021acs.jmedchem.3c01681.pdf 0 2.8 MB Publisher’s postprint open-access - 3.0574332 - ÚOCHB 2024 RIV NL eng J - Journal Article
Novotná, Kateřina - Thomas, A. G. - Štěpánek, O. - Murphy, B. - Hin, N. - Skácel, J. - Mueller, L. - Tenora, Lukáš - Pal, A. - Alt, J. - Wu, Y. - Paule, J. - Rais, R. - Slusher, B. S. - Tsukamoto, T.
Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold.
European Journal of Medicinal Chemistry. Roč. 259, November (2023), č. článku 115674. ISSN 0223-5234. E-ISSN 1768-3254
Institutional support: RVO:61388963
Keywords : phosphodiesterase * neutral sphingomyelinase 2 * ceramide * sphingomyelin * pyrazolo[1,5-a]pyrimidin-3-amine
OECD category: Medicinal chemistry
Impact factor: 6.7, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.ejmech.2023.115674
Permanent Link: https://hdl.handle.net/11104/0344672 - 4.0570701 - FGÚ 2024 RIV US eng J - Journal Article
Witkowski, M. - Nemet, I. - Alamri, H. - Wilcox, J. - Gupta, N. - Nimer, N. - Haghikia, A. - Li, X. S. - Wu, Y. - Saha, P. P. - Demuth, I. - König, M. - Steinhagen-Thiessen, E. - Čajka, Tomáš - Fiehn, O. - Landmesser, U. - Tang, W.H.W. - Hazen, S.L.
The artificial sweetener erythritol and cardiovascular event risk.
Nature Medicine. Roč. 29, March (2023), s. 710-718. ISSN 1078-8956. E-ISSN 1546-170X
Institutional support: RVO:67985823
Keywords : sweeteners * erythritol * metabolomics * cardiovascular event risk
OECD category: Cardiac and Cardiovascular systems
Impact factor: 82.9, year: 2022
Method of publishing: Limited access
https://doi.org/10.1038/s41591-023-02223-9
Permanent Link: https://hdl.handle.net/11104/0342032 - 5.0565069 - ÚOCHB 2023 RIV US eng J - Journal Article
Rais, R. - Lemberg, K. M. - Tenora, Lukáš - Arwood, M. L. - Pal, A. - Alt, J. - Wu, Y. - Lam, J. - Aguilar, J. M. H. - Zhao, L. - Peters, D. E. - Tallon, C. - Pandey, R. - Thomas, A. G. - Dash, R. P. - Seiwert, T. - Majer, Pavel - Leone, R. D. - Powell, J. D. - Slusher, B. S.
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
Science Advances. Roč. 8, č. 46 (2022), č. článku eabq5925. ISSN 2375-2548. E-ISSN 2375-2548
R&D Projects: GA MŠMT LTAUSA18166
Institutional support: RVO:61388963
Keywords : 6-diazo-5-oxo-l-norleucine DON * phase II * glutamine metabolism
OECD category: Organic chemistry
Impact factor: 13.6, year: 2022
Method of publishing: Open access
https://doi.org/10.1126/sciadv.abq5925
Permanent Link: https://hdl.handle.net/11104/0336617 - 6.0547369 - ÚOCHB 2022 RIV AE eng J - Journal Article
Alt, J. - Gori, S. S. - Lemberg, K. M. - Pal, A. - Veeravalli, V. - Wu, Y. - Aguilar, J. M. H. - Dash, R. P. - Tenora, Lukáš - Majer, Pavel - Sun, Q. - Slusher, B. S. - Rais, R.
Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement.
Current Drug Metabolism. Roč. 22, č. 9 (2021), s. 735-745. ISSN 1389-2002. E-ISSN 1875-5453
R&D Projects: GA MŠMT LTAUSA18166
Institutional support: RVO:61388963
Keywords : Glutamine antagonist * purine synthesis * formylglycinamide ribonucleotide * formylglycinamidine ribonucleotide * biomarker * cancer * LC-MS
OECD category: Organic chemistry
Impact factor: 3.408, year: 2021
Method of publishing: Limited access
https://doi.org/10.2174/1389200222666210831125041
Permanent Link: http://hdl.handle.net/11104/0323608 - 7.0524906 - FGÚ 2021 RIV US eng J - Journal Article
Nemet, I. - Saha, P. P. - Gupta, N. - Zhu, W. - Romano, K. A. - Skye, S. M. - Čajka, Tomáš - Mohan, M. L. - Li, L. - Wu, Y. - Funabashi, M. - Ramer-Tait, A. E. - Prasad, S. V. N. - Fiehn, O. - Rey, F. E. - Tang, W.H.W. - Fischbach, M. A. - DiDonato, J. A. - Hazen, S.L.
A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors.
Cell. Roč. 180, č. 5 (2020), s. 862-877. ISSN 0092-8674. E-ISSN 1097-4172
Institutional support: RVO:67985823
Keywords : gut microbe * metabolomics * cardiovascular disease * GPCR * adrenergic receptors * thrombosis
OECD category: Cardiac and Cardiovascular systems
Impact factor: 41.584, year: 2020
Method of publishing: Limited access
https://doi.org/10.1016/j.cell.2020.02.016
Permanent Link: http://hdl.handle.net/11104/0309134 - 8.0522291 - ÚOCHB 2021 RIV US eng J - Journal Article
Lemberg, K. M. - Zhao, L. - Wu, Y. - Veeravalli, V. - Alt, J. - Aguilar, J. M. H. - Dash, R. P. - Lam, J. - Tenora, Lukáš - Rodriguez, C. - Nedelcovych, M. T. - Brayton, C. - Majer, Pavel - Blakeley, J. O. - Rais, R. - Slusher, B. S.
The Novel Glutamine Antagonist Prodrug JHU395 Has Antitumor Activity in Malignant Peripheral Nerve Sheath Tumor.
Molecular Cancer Therapeutics. Roč. 19, č. 2 (2020), s. 397-408. ISSN 1535-7163. E-ISSN 1538-8514
R&D Projects: GA MŠMT LTAUSA18166
Institutional support: RVO:61388963
Keywords : 6-diazo-5-oxo-L-norleucine DON * cancer * metabolism
OECD category: Organic chemistry
Impact factor: 6.261, year: 2020
Method of publishing: Limited access
https://mct.aacrjournals.org/content/19/2/397
Permanent Link: http://hdl.handle.net/11104/0306808 - 9.0510193 - ÚOCHB 2020 RIV US eng J - Journal Article
Dash, R. P. - Tichý, Tomáš - Veeravalli, V. - Lam, J. - Alt, J. - Wu, Y. - Tenora, Lukáš - Majer, Pavel - Slusher, B. S. - Rais, R.
Enhanced Oral Bioavailability of 2-(Phosphonomethyl)-pentanedioic Acid (2-PMPA) from its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs.
Molecular Pharmaceutics. Roč. 16, č. 10 (2019), s. 4292-4301. ISSN 1543-8384. E-ISSN 1543-8392
Institutional support: RVO:61388963
Keywords : 2-PMPA * glutamate carboxypeptidase II * oral bioavailability * pharmacokinetics * prodrugs
OECD category: Organic chemistry
Impact factor: 4.321, year: 2019
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b00637
Permanent Link: http://hdl.handle.net/11104/0300720 - 10.0507816 - FGÚ 2020 RIV US eng J - Journal Article
Podolnikova, N. P. - Hlaváčková, Markéta - Wu, Y. - Yakubenko, V. P. - Faust, J. - Balabiyev, A. - Wang, X. - Ugarova, T. P.
Interaction between the integrin Mac-1 and signal regulatory protein (SIRP) mediates fusion in heterologous cells.
Journal of Biological Chemistry. Roč. 294, č. 19 (2019), s. 7833-7849. ISSN 0021-9258. E-ISSN 1083-351X
Institutional support: RVO:67985823
Keywords : integrin * cell adhesion * cell-cell interaction * structure-function * macrophage * cell-cell fusion * chronic inflammation
OECD category: Physiology (including cytology)
Impact factor: 4.238, year: 2019
Method of publishing: Open access with time embargo
https://www.jbc.org/content/294/19/7833
Permanent Link: http://hdl.handle.net/11104/0298783