Search results
- 1.0458657 - ÚOCHB 2017 RIV GB eng J - Journal Article
Viková, Jitka - Collinsová, Michaela - Kletvíková, Emília - Buděšínský, Miloš - Kaplan, V. - Žáková, Lenka - Veverka, Václav - Hexnerová, Rozálie - Tarazona Avinó, R. J. - Straková, Jana - Selicharová, Irena - Vaněk, Václav - Wright, D. W. - Watson, C. J. - Turkenburg, J. P. - Brzozowski, A. M. - Jiráček, Jiří
Rational steering of insulin binding specificity by intra-chain chemical crosslinking.
Scientific Reports. Roč. 6, Jan 21 (2016), č. článku 19431. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA MŠMT(CZ) LK11205; GA MŠMT(CZ) LO1304
Institutional support: RVO:61388963
Keywords : insulin * insulin receptor * diabetes * protein design * protein synthesis
Subject RIV: CE - Biochemistry
Impact factor: 4.259, year: 2016
http://www.nature.com/articles/srep19431
Permanent Link: http://hdl.handle.net/11104/0258905File Download Size Commentary Version Access 0458657.pdf 5 2.4 MB Publisher’s postprint open-access - 2.0435229 - ÚOCHB 2015 RIV US eng J - Journal Article
Žáková, Lenka - Kletvíková, Emília - Lepšík, Martin - Collinsová, Michaela - Watson, C. J. - Turkenburg, J. P. - Jiráček, Jiří - Brzozowski, A. M.
Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex.
Acta Crystallographica Section D-Biological Crystallography. Roč. 70, č. 10 (2014), s. 2765-2774. ISSN 0907-4449
R&D Projects: GA ČR GPP207/11/P430; GA ČR GBP208/12/G016
Institutional support: RVO:61388963
Keywords : insulin * insulin receptor * complex * active form * analog * structure
Subject RIV: CE - Biochemistry
Impact factor: 7.232, year: 2013
Permanent Link: http://hdl.handle.net/11104/0239539 - 3.0392749 - ÚOCHB 2014 RIV US eng J - Journal Article
Žáková, Lenka - Kletvíková, Emília - Veverka, Václav - Lepšík, Martin - Watson, C. J. - Turkenburg, J. P. - Jiráček, Jiří - Brzozowski, A. M.
Structural Integrity of the B24 Site in Human Insulin Is Important for Hormone Functionality.
Journal of Biological Chemistry. Roč. 288, č. 15 (2013), s. 10230-10240. ISSN 0021-9258. E-ISSN 1083-351X
R&D Projects: GA ČR GPP207/11/P430; GA MŠMT(CZ) LK11205
Institutional support: RVO:61388963
Keywords : insulin * insulin receptor * structure * NMR
Subject RIV: CE - Biochemistry
Impact factor: 4.600, year: 2013
Permanent Link: http://hdl.handle.net/11104/0221560 - 4.0391760 - ÚOCHB 2014 RIV GB eng J - Journal Article
Menting, J. G. - Whittaker, J. - Margetts, M. B. - Whittaker, L. J. - Kong, G. K. W. - Smith, B. J. - Watson, C. J. - Žáková, Lenka - Kletvíková, Emília - Jiráček, Jiří - Chan, S. J. - Steiner, D. F. - Dodson, G. G. - Brzozowski, A. M. - Weiss, M. A. - Ward, C. W. - Lawrence, M. C.
How insulin engages its primary binding site on the insulin receptor.
Nature. Roč. 493, č. 7431 (2013), s. 241-245. ISSN 0028-0836. E-ISSN 1476-4687
R&D Projects: GA ČR GPP207/11/P430
Institutional support: RVO:61388963
Keywords : insulin * receptor * complex * crystal structure
Subject RIV: CE - Biochemistry
Impact factor: 42.351, year: 2013
Permanent Link: http://hdl.handle.net/11104/0220731 - 5.0366020 - ÚOCHB 2012 RIV US eng J - Journal Article
Antolíková, Emília - Žáková, Lenka - Turkenburg, J. P. - Watson, C. J. - Hančlová, Ivona - Šanda, Miloslav - Cooper, A. - Kraus, Tomáš - Brzozowski, A. M. - Jiráček, Jiří
Non-equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface.
Journal of Biological Chemistry. Roč. 286, č. 42 (2011), s. 36968-36977. ISSN 0021-9258. E-ISSN 1083-351X
R&D Projects: GA MŠMT(CZ) LC06077
Institutional research plan: CEZ:AV0Z40550506
Keywords : insulin * dimer * analog
Subject RIV: CC - Organic Chemistry
Impact factor: 4.773, year: 2011
Permanent Link: http://hdl.handle.net/11104/0201123 - 6.0342433 - ÚOCHB 2011 RIV US eng J - Journal Article
Jiráček, Jiří - Žáková, Lenka - Antolíková, Emília - Watson, C. J. - Turkenburg, J. P. - Dodson, G. G. - Brzozowski, A. M.
Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues.
Proceedings of the National Academy of Sciences of the United States of America. Roč. 107, č. 5 (2010), s. 1966-1970. ISSN 0027-8424. E-ISSN 1091-6490
R&D Projects: GA MŠMT(CZ) LC06077; GA AV ČR KJB400550702
Institutional research plan: CEZ:AV0Z40550506
Keywords : insulin * analogue * conformation * beta-turn * N-methylation
Subject RIV: CC - Organic Chemistry
Impact factor: 9.771, year: 2010
Permanent Link: http://hdl.handle.net/11104/0185172