Search results
- 1.0579447 - ÚOCHB 2025 RIV GB eng J - Journal Article
Misehe, Mbilo - Šála, Michal - Matoušová, Marika - Hercík, Kamil - Kocek, Hugo - Chalupská, Dominika - Chaloupecká, Ema - Hájek, Miroslav - Bouřa, Evžen - Mertlíková-Kaiserová, Helena - Nencka, Radim
Design, synthesis and evaluation of novel thieno[2,3d]pyrimidine derivatives as potent and specific RIPK2 inhibitors.
Bioorganic & Medicinal Chemistry. Roč. 97, January (2024), č. článku 129567. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MZd(CZ) NU20-05-00472; GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963
Keywords : kinase inhibitor * thieno [2,3d] pyrimidine derivative * receptor-interacting protein kinase 2 * RIPK2 * NOD
Impact factor: 3.5, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.bmcl.2023.129567
Permanent Link: https://hdl.handle.net/11104/0348249File Download Size Commentary Version Access 10.1016j.bmcl.2023.129567.pdf 0 1.6 MB Publisher’s postprint open-access - 2.0574898 - ÚOCHB 2024 RIV NL eng J - Journal Article
Misehe, Mbilo - Matoušová, Marika - Dvořáková, Alexandra - Hercík, Kamil - Škach, Kryštof - Chalupská, Dominika - Dejmek, Milan - Šála, Michal - Hájek, Miroslav - Bouřa, Evžen - Mertlíková-Kaiserová, Helena - Nencka, Radim
Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases.
European Journal of Medicinal Chemistry. Roč. 260, November (2023), č. článku 115717. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) LX22NPO5103; GA MZd(CZ) NU20-05-00472
Institutional support: RVO:61388963
Keywords : kinase inhibitor * quinazoline derivatives * RIPK2 * NOD * inflammation * RIPK3
OECD category: Medicinal chemistry
Impact factor: 6.7, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.ejmech.2023.115717
Permanent Link: https://hdl.handle.net/11104/0344824File Download Size Commentary Version Access 10.1016j.ejmech.2023.115717.pdf 0 4.4 MB Publisher’s postprint open-access - 3.0562658 - ÚOCHB 2023 RIV GB eng J - Journal Article
Misehe, Mbilo - Klíma, Martin - Matoušová, Marika - Chalupská, Dominika - Dejmek, Milan - Šála, Michal - Mertlíková-Kaiserová, Helena - Bouřa, Evžen - Nencka, Radim
Structure-based design and modular synthesis of novel PI4K class II inhibitors bearing a 4-aminoquinazoline scaffold.
Bioorganic and Medicinal Chemistry Letters. Roč. 76, November (2022), č. článku 129010. ISSN 0960-894X. E-ISSN 1464-3405
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA MZd(CZ) NU20-05-00472
Institutional support: RVO:61388963
Keywords : phosphatidylinositol 4-kinase class II * PI4K2A inhibitor * quinazoline derivative * SAR investigation * ATP-binding site
OECD category: Biochemistry and molecular biology
Impact factor: 2.7, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.bmcl.2022.129010
Permanent Link: https://hdl.handle.net/11104/0334914
Research data: PDB - 4.0558330 - ÚOCHB 2023 RIV NL eng J - Journal Article
Voldřich, Jan - Matoušová, Marika - Šmídková, Markéta - Slavíková, Barbora - Chodounská, Hana - Kudová, Eva - Mertlíková-Kaiserová, Helena
Identification of N-methyl-D-aspartate receptor antagonists using the rat postnatal mixed cortical and hippocampal neurons.
European Journal of Pharmacology. Roč. 927, July (2022), č. článku 175056. ISSN 0014-2999. E-ISSN 1879-0712
R&D Projects: GA TA ČR(CZ) TN01000013
Institutional support: RVO:61388963
Keywords : NMDA receptors * primary neurons * iPSC * neurosteroids
OECD category: Biochemistry and molecular biology
Impact factor: 5, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.ejphar.2022.175056
Permanent Link: http://hdl.handle.net/11104/0332052 - 5.0558020 - ÚOCHB 2023 RIV DE eng J - Journal Article
Pošta, Martin - Zima, Václav - Poštová Slavětínská, Lenka - Matoušová, Marika - Beier, Petr
Synthesis of sulfur karrikin bioisosteres as potential neuroprotectives.
Beilstein Journal of Organic Chemistry. Roč. 18, May (2022), s. 549-554. ISSN 1860-5397. E-ISSN 1860-5397
R&D Projects: GA ČR(CZ) GA20-11571S
Institutional support: RVO:61388963
Keywords : acetylcholinesterase * butenolides * karrikin * sulfur
OECD category: Organic chemistry
Impact factor: 2.7, year: 2022
Method of publishing: Open access
https://doi.org/10.3762/bjoc.18.57
Permanent Link: http://hdl.handle.net/11104/0331842 - 6.0538814 - ÚOCHB 2022 RIV US eng J - Journal Article
Dzijak, Rastislav - Galeta, Juraj - Vázquez, Arcadio - Kozák, Jaroslav - Matoušová, Marika - Fulka, Helena - Dračínský, Martin - Vrábel, Milan
Structurally Redesigned Bioorthogonal Reagents for Mitochondria-Specific Prodrug Activation.
JACS Au. Roč. 1, č. 1 (2021), s. 23-30. E-ISSN 2691-3704
R&D Projects: GA ČR(CZ) GA19-13811S
EU Projects: European Commission(XE) 677465 - SWEETOOLS
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : bioorthogonal reactions * click-to-release * mitochondria * prodrug activation * tetrazines
OECD category: Organic chemistry; Medicinal chemistry (UEM-P)
Method of publishing: Open access
https://doi.org/10.1021/jacsau.0c00053
Permanent Link: http://hdl.handle.net/11104/0316967 - 7.0538783 - ÚOCHB 2022 RIV GB eng J - Journal Article
Pomeislová, Alice - Otmar, Miroslav - Rubešová, Petra - Benýšek, Jakub - Matoušová, Marika - Mertlíková-Kaiserová, Helena - Pohl, Radek - Poštová Slavětínská, Lenka - Pomeisl, Karel - Krečmerová, Marcela
1,2,4-Thiadiazole acyclic nucleoside phosphonates as inhibitors of cysteine dependent enzymes cathepsin K and GSK-3β.
Bioorganic & Medicinal Chemistry. Roč. 32, Feb 15 (2021), č. článku 115998. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT(CZ) LM2018133; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963 ; RVO:61389013 ; RVO:68378271
Keywords : thiadiazoles * 5-amino-1,2,4-thiadiazol-3-(2H)-one * acyclic nucleoside phosphonates * epigenetic * cathepsin K * glycogen synthase kinase 3β
OECD category: Biochemistry and molecular biology; Polymer science (UMCH-V); Organic chemistry (FZU-D)
Impact factor: 3.461, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.bmc.2021.115998
Permanent Link: http://hdl.handle.net/11104/0316958 - 8.0505510 - ÚOCHB 2020 RIV GB eng J - Journal Article
Šmídková, Markéta - Hájek, Miroslav - Adla, Santosh Kumar - Slavíková, Barbora - Chodounská, Hana - Matoušová, Marika - Mertlíková-Kaiserová, Helena - Kudová, Eva
Screening of novel 3 alpha 5 beta-neurosteroids for neuroprotective activity against glutamate- or NMDA-induced excitotoxicity.
Journal of Steroid Biochemistry and Molecular Biology. Roč. 189, May (2019), s. 195-203. ISSN 0960-0760
R&D Projects: GA TA ČR(CZ) TE01020028; GA MŠMT LO1302; GA TA ČR(CZ) TN01000013
Institutional support: RVO:61388963
Keywords : neurosteroids * NMDAR * glutamate excitotoxicity * neuroprotection
OECD category: Biochemistry and molecular biology
Impact factor: 3.813, year: 2019
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/abs/pii/S0960076019300378?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0296991 - 9.0501437 - ÚOCHB 2020 RIV US eng J - Journal Article
Matoušová, Marika - Souček, Radko - Tloušťová, Eva - Slavíková, Barbora - Chodounská, Hana - Mertlíková-Kaiserová, Helena - Kudová, Eva
Pregn-5-en-3beta-ol and androst-5-en-3beta-ol dicarboxylic acid esters as potential therapeutics for NMDA hypofunction: In vitro safety assessment and plasma stability.
Steroids. Roč. 147, Jul (2019), s. 4-9. ISSN 0039-128X. E-ISSN 1878-5867
R&D Projects: GA ČR(CZ) GA17-02300S; GA MZd(CZ) NV15-29370A; GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : neurosteroid * NMDA receptor hypofunction * hepatotoxicity * mitotoxicity * Caco-2 permeability * plasma stability
OECD category: Neurosciences (including psychophysiology
Impact factor: 1.948, year: 2019
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/abs/pii/S0039128X18301752?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0296235 - 10.0474385 - ÚOCHB 2018 RIV US eng J - Journal Article
Mejdrová, Ivana - Chalupská, Dominika - Plačková, Pavla - Müller, C. - Šála, Michal - Klíma, Martin - Bäumlová, Adriana - Hřebabecký, Hubert - Procházková, Eliška - Dejmek, Milan - Strunin, Dmytro - Weber, Jan - Lee, G. - Matoušová, Marika - Mertlíková-Kaiserová, Helena - Ziebuhr, J. - Birkuš, G. - Bouřa, Evžen - Nencka, Radim
Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase III beta (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.
Journal of Medicinal Chemistry. Roč. 60, č. 1 (2017), s. 100-118. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GA15-09310S
EU Projects: European Commission(XE) 333916 - STARPI4K
Institutional support: RVO:61388963
Keywords : C virus replication * lipid kinase * crystal structure
OECD category: Organic chemistry
Impact factor: 6.253, year: 2017
Permanent Link: http://hdl.handle.net/11104/0271447
Research data: CSB Protein Data Bank, CSB Protein Data Bank, CSB Protein Data Bank, CSB Protein Data Bank, CSB Protein Data Bank