Search results
- 1.0585825 - ÚOCHB 2025 RIV US eng J - Journal Article
Keough, D. T. - Petrová, Magdalena - King, G. - Kratochvil, Michal - Pohl, Radek - Doležalová, E. - Ziková, A. - Guddat, L. W. - Rejman, Dominik
Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design.
Journal of Medicinal Chemistry. Roč. 67, č. 9 (2024), s. 7158-7175. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963
Keywords : trypanosomiasis * hxgprt * prolinol nucleoside bisphosphonate
OECD category: Organic chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.4c00021
Permanent Link: https://hdl.handle.net/11104/0353500File Download Size Commentary Version Access 10.1021acs.jmedchem.4c00021.pdf 0 12.2 MB Publisher’s postprint open-access - 2.0573369 - ÚOCHB 2024 RIV US eng J - Journal Article
Vaňková, Karolína - Keough, D. T. - Hocková, Dana - Guddat, L. W. - Janeba, Zlatko
N2'-Branched Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine as Inhibitors of Plasmodium falciparum 6-Oxopurine Phosphoribosyltransferase.
ChemMedChem. Roč. 18, č. 15 (2023), č. článku e202300211. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA ČR(CZ) GA19-07707S
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * inhibitors * hypoxanthine-guanine-(xanthine) phosphoribosyltransferase * malaria * Plasmodium falciparum
OECD category: Organic chemistry
Impact factor: 3.4, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/cmdc.202300211
Permanent Link: https://hdl.handle.net/11104/0343833 - 3.0556761 - ÚOCHB 2023 RIV US eng J - Journal Article
Klejch, Tomáš - Keough, D. T. - King, G. - Doleželová, Eva - Česnek, Michal - Buděšínský, Miloš - Zíková, Alena - Janeba, Zlatko - Guddat, L. W. - Hocková, Dana
Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases.
Journal of Medicinal Chemistry. Roč. 65, č. 5 (2022), s. 4030-4057. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR(CZ) GA19-07707S; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : hypoxanthine-guanine phosporibosyltransferase * Plasmodium falciparum * Helicobacter pylori
OECD category: Medicinal chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c01881
Permanent Link: http://hdl.handle.net/11104/0330950 - 4.0542267 - ÚOCHB 2022 RIV US eng J - Journal Article
Keough, D. T. - Wun, J. S. - Baszczyňski, Ondřej - Eng, W. S. - Špaček, Petr - Panjikar, S. - Naesens, L. - Pohl, Radek - Rejman, Dominik - Hocková, Dana - Ferrero, R. L. - Guddat, L. W.
Helicobacter pylori Xanthine–Guanine–Hypoxanthine Phosphoribosyltransferase—A Putative Target for Drug Discovery against Gastrointestinal Tract Infections.
Journal of Medicinal Chemistry. Roč. 64, č. 9 (2021), s. 5710-5729. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR(CZ) GA19-07707S
Institutional support: RVO:61388963
Keywords : XGHPRT * inhibitor * phosphonate * nucleotide
OECD category: Organic chemistry
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.0c02184
Permanent Link: http://hdl.handle.net/11104/0319726 - 5.0542010 - ÚOCHB 2022 RIV FR eng J - Journal Article
Frydrych, Jan - Keough, D. T. - Chavchich, M. - Travis, J. - Dračínský, Martin - Edstein, M. D. - Guddat, L. W. - Hocková, Dana - Janeba, Zlatko
Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity.
European Journal of Medicinal Chemistry. Roč. 219, Jul 5 (2021), č. článku 113416. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA19-07707S
Institutional support: RVO:61388963
Keywords : nucleoside phosphonates * phosphoroamidate prodrug * HG(X)PRT * hypoxanthine-guanine-(xanthine) phosphoribosyltransferase * Plasmodium falciparum * Plasmodium vivax
OECD category: Organic chemistry
Impact factor: 7.088, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.ejmech.2021.113416
Permanent Link: http://hdl.handle.net/11104/0319509 - 6.0519629 - BC 2020 RIV GB eng J - Journal Article
Terán, D. - Doleželová, Eva - Keough, D. T. - Hocková, Dana - Zíková, Alena - Guddat, L. W.
Crystal structures of Trypanosoma brucei hypoxanthine - guanine - xanthine phosphoribosyltransferase in complex with IMP, GMP and XMP.
FEBS Journal. Roč. 286, č. 23 (2019), s. 4721-4736. ISSN 1742-464X. E-ISSN 1742-4658
R&D Projects: GA ČR(CZ) GA19-07707S; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344 ; RVO:61388963
Keywords : purine salvage * 6-oxopurine phosphoribosyltransferase * tritrichomonas-fetus * drug-resistance * pyrophosphate * enzyme * state * inhibitors * mutations * cloning * 6-oxopurine phosphoribosyltransferase * gmp * imp * purine salvage * Trypanosoma brucei * xmp
OECD category: Organic chemistry; Organic chemistry (UOCHB-X)
Impact factor: 4.392, year: 2019
Method of publishing: Limited access
https://febs.onlinelibrary.wiley.com/doi/pdf/10.1111/febs.14987
Permanent Link: http://hdl.handle.net/11104/0304637 - 7.0510479 - ÚOCHB 2020 RIV FR eng J - Journal Article
Klejch, Tomáš - Keough, D. T. - Chavchich, M. - Travis, J. - Skácel, Jan - Pohl, Radek - Janeba, Zlatko - Edstein, M. D. - Avery, V. M. - Guddat, L. W. - Hocková, Dana
Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation.
European Journal of Medicinal Chemistry. Roč. 183, Dec 1 (2019), č. článku 111667. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA16-06049S
Institutional support: RVO:61388963
Keywords : hypoxanthine-guanine-xanthine phosphoribosyltransferase * sulfur-containing drugs * sulfide oxidation * Plasmodium falciparum * acyclic nucleoside phosphonates
OECD category: Organic chemistry
Impact factor: 5.573, year: 2019
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/abs/pii/S0223523419308116?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0300951 - 8.0498922 - BC 2019 RIV US eng J - Journal Article
Doleželová, Eva - Terán, D. - Gahura, Ondřej - Kotrbová, Zuzana - Procházková, Michaela - Keough, D. T. - Špaček, Petr - Hocková, Dana - Guddat, L. - Zíková, Alena
Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.
PLoS Neglected Tropical Diseases. Roč. 12, č. 2 (2018), č. článku e0006301. ISSN 1935-2735. E-ISSN 1935-2735
R&D Projects: GA ČR(CZ) GA16-06049S; GA MŠMT LL1205
Institutional support: RVO:60077344 ; RVO:61388963
Keywords : hypoxanthine-guanine phosphoribosyltransferase * acyclic nucleoside phosphonates * human african trypanosomiasis * inducible expression system * purine salvage * plasmodium-falciparum * crystal-structures * xanthine phosphoribosyltransferase * mycobacterium-tuberculosis * antimalarial activity
OECD category: Microbiology; Organic chemistry (UOCHB-X)
Impact factor: 4.487, year: 2018
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006301
Permanent Link: http://hdl.handle.net/11104/0291797 - 9.0498560 - ÚOCHB 2019 RIV FR eng J - Journal Article
Eng, W. S. - Rejman, Dominik - Pohl, Radek - West, N. P. - Woods, K. - Naesens, L. M. J. - Keough, D. T. - Guddat, L. W.
Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase.
European Journal of Medicinal Chemistry. Roč. 159, Nov 5 (2018), s. 10-22. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MZd(CZ) NV17-29680A; GA ČR GA15-11711S
Institutional support: RVO:61388963
Keywords : Mycobacterium tuberculosis * therapeutic drug leads * X-ray crystal structures * hypoxanthine-guanine phosphoribosyltransferase * pyrrolidine nucleoside phosphonates * pyrrolidine nucleoside bisphosphonates * phosphoramidate prodrugs
OECD category: Organic chemistry
Impact factor: 4.833, year: 2018
Permanent Link: http://hdl.handle.net/11104/0290893 - 10.0495494 - ÚOCHB 2019 RIV GB eng J - Journal Article
Klejch, Tomáš - Pohl, Radek - Janeba, Zlatko - Sun, M. - Keough, D. T. - Guddat, L. W. - Hocková, Dana
Acyclic nucleoside phosphonates with unnatural nucleobases, favipiravir and allopurinol, designed as potential inhibitors of the human and Plasmodium falciparum 6-oxopurine phosphoribosyltransferases.
Tetrahedron. Roč. 74, č. 40 (2018), s. 5886-5897. ISSN 0040-4020. E-ISSN 1464-5416
R&D Projects: GA ČR(CZ) GA16-06049S
Institutional support: RVO:61388963
Keywords : hypoxanthine-guanine-xanthine phosphoribosyltransferase * regioselective Mitsunobu reaction * acyclic nucleotide analogues * enzyme inhibition
OECD category: Organic chemistry
Impact factor: 2.379, year: 2018
Permanent Link: http://hdl.handle.net/11104/0288465