Search results
- 1.0438380 - ÚOCHB 2015 RIV GB eng J - Journal Article
Jílková, Adéla - Horn, Martin - Řezáčová, Pavlína - Marešová, Lucie - Fajtová, Pavla - Brynda, Jiří - Vondrášek, Jiří - McKerrow, J. H. - Caffrey, C. R. - Mareš, Michael
Activation Route of the Schistosoma mansoni Cathepsin B1 Drug Target: Structural Map with a Glycosaminoglycan Switch.
Structure. Roč. 22, č. 12 (2014), s. 1786-1798. ISSN 0969-2126. E-ISSN 1878-4186
R&D Projects: GA ČR GA203/09/1585; GA MŠMT LH12023; GA MŠMT LO1302
Institutional support: RVO:61388963 ; RVO:68378050
Keywords : human procathepsin B * slow binding inhibition * asparaginyl endopeptidase
Subject RIV: CE - Biochemistry
Impact factor: 5.618, year: 2014
Permanent Link: http://hdl.handle.net/11104/0241842 - 2.0422118 - ÚOCHB 2014 RIV US eng J - Journal Article
Fanfrlík, Jindřich - Brahmkshatriya, Pathik - Řezáč, Jan - Jílková, Adéla - Horn, Martin - Mareš, Michael - Hobza, Pavel - Lepšík, Martin
Quantum Mechanics-Based Scoring Rationalizes the Irreversible Inactivation of Parasitic Schistosoma mansoni Cysteine Peptidase by Vinyl Sulfone Inhibitors.
Journal of Physical Chemistry B. Roč. 117, č. 48 (2013), s. 14973-14982. ISSN 1520-6106. E-ISSN 1520-5207
R&D Projects: GA ČR GBP208/12/G016; GA ČR GA203/09/1585; GA MŠMT LH12023
Grant - others:European Science Fund(XE) CZ.1.05/2.1.00/03.0058
Institutional support: RVO:61388963
Keywords : density-functional theory * protein-ligand * drug design
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 3.377, year: 2013
Permanent Link: http://hdl.handle.net/11104/0228354 - 3.0365166 - ÚOCHB 2012 RIV US eng J - Journal Article
Jílková, Adéla - Řezáčová, Pavlína - Lepšík, Martin - Horn, Martin - Váchová, Jana - Fanfrlík, Jindřich - Brynda, Jiří - McKerrow, J. H. - Caffrey, C. R. - Mareš, Michael
Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni.
Journal of Biological Chemistry. Roč. 286, č. 41 (2011), s. 35770-35881. ISSN 0021-9258. E-ISSN 1083-351X
R&D Projects: GA ČR GA203/09/1585; GA ČR GAP208/11/0295; GA MŠMT OC09007
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50520514
Keywords : cathepsin B * schistosoma * crystal structure
Subject RIV: CC - Organic Chemistry
Impact factor: 4.773, year: 2011
Permanent Link: http://hdl.handle.net/11104/0200472 - 4.0360455 - ÚOCHB 2012 RIV US eng J - Journal Article
Horn, Martin - Jílková, Adéla - Vondrášek, Jiří - Marešová, Lucie - Caffrey, C. R. - Mareš, Michael
Mapping the Pro-Peptide of the Schistosoma mansoni Cathepsin B1 Drug Target: Modulation of Inhibition by Heparin and Design of Mimetic Inhibitors.
ACS Chemical Biology. Roč. 6, č. 6 (2011), s. 609-617. ISSN 1554-8929. E-ISSN 1554-8937
R&D Projects: GA ČR GA203/09/1585; GA AV ČR KJB400550516; GA AV ČR IAA400550705
Grant - others:NATO(XE) NATO LST/CLG 980187
Institutional research plan: CEZ:AV0Z40550506
Keywords : Schistosoma mansoni * cathepsin B * propeptide
Subject RIV: CE - Biochemistry
Impact factor: 6.446, year: 2011
Permanent Link: http://hdl.handle.net/11104/0198006 - 5.0349491 - BC 2012 RIV US eng J - Journal Article
Štefanič, S. - Dvořák, Jan - Horn, Martin - Braschi, S. - Sojka, Daniel - Ruelas, D. - Suzuki, B. - Lim, K.-C. - Hopkins, S. D. - McKerrow, J. H. - Caffrey, C. R.
RNA Interference in Schistosoma mansoni Schistosomula: Selectivity, Sensitivity and Operation for Larger-Scale Screening.
PLoS Neglected Tropical Diseases. Roč. 4, č. 10 (2010), e850. ISSN 1935-2735. E-ISSN 1935-2735
R&D Projects: GA ČR GA203/09/1585; GA AV ČR KJB600960911; GA MŠMT(CZ) LC06009; GA MŠMT(CZ) ME10011
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z60220518
Keywords : Tropical disease * Schistosoma * schistosomula * RNAi * protease * tegument * drug target * drug discovery
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.752, year: 2010
Permanent Link: http://hdl.handle.net/11104/0189712