Search results
- 1.0454405 - FGÚ 2016 RIV CZ eng J - Journal Article
Jakubík, Jan - El-Fakahany, E. E. - Doležal, Vladimír
Towards predictive docking at aminergic G-protein coupled receptors.
Journal of Molecular Modeling. Roč. 21, č. 11 (2015), s. 284. ISSN 1610-2940. E-ISSN 0948-5023
R&D Projects: GA ČR(CZ) GBP304/12/G069; GA ČR(CZ) GA14-05696S; GA ČR(CZ) GA305/09/0681
Institutional support: RVO:67985823
Keywords : induced-fit docking * pose scoring * molecular dynamics * ligand-receptor interaction
Subject RIV: FH - Neurology
Impact factor: 1.438, year: 2015
Permanent Link: http://hdl.handle.net/11104/0255085 - 2.0448654 - FGÚ 2016 RIV GB eng J - Journal Article
Randáková, Alena - Dolejší, Eva - Rudajev, Vladimír - Zimčík, Pavel - Doležal, Vladimír - El-Fakahany, E. E. - Jakubík, Jan
Classical and atypical agonists activate M1 muscarinic acetylcholine receptors through common mechanisms.
Pharmacological Research. Roč. 97, Jul 2015 (2015), s. 27-39. ISSN 1043-6618. E-ISSN 1096-1186
R&D Projects: GA ČR(CZ) GA305/09/0681; GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) EE2.3.30.0025
Institutional support: RVO:67985823
Keywords : muscarinic acetylcholine receptors * atypical agonists * xanomeline * activation mechanism
Subject RIV: ED - Physiology
Impact factor: 4.816, year: 2015
Permanent Link: http://hdl.handle.net/11104/0250288 - 3.0431597 - FGÚ 2015 RIV US eng J - Journal Article
Jakubík, Jan - Zimčík, Pavel - Randáková, Alena - Fuksová, Květoslava - El-Fakahany, E. E. - Doležal, Vladimír
Molecular Mechanisms of Methoctramine Binding and Selectivity at Muscarinic Acetylcholine Receptors.
Molecular Pharmacology. Roč. 86, č. 2 (2014), s. 180-192. ISSN 0026-895X. E-ISSN 1521-0111
R&D Projects: GA ČR(CZ) GAP304/12/0259; GA ČR(CZ) GA305/09/0681
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823 ; RVO:61389030
Keywords : muscarinic receptors * selectivity * methoctramine * allosteric * FRET
Subject RIV: ED - Physiology
Impact factor: 4.128, year: 2014
Permanent Link: http://hdl.handle.net/11104/0236229 - 4.0428162 - FGÚ 2015 RIV CZ eng J - Journal Article
Jakubík, Jan - Šantrůčková, Eva - Randáková, Alena - Janíčková, Helena - Zimčík, Pavel - Rudajev, Vladimír - Michal, Pavel - El-Fakahany, E. E. - Doležal, Vladimír
Outline of therapeutic interventions with muscarinic receptor-mediated transmission.
Physiological Research. Roč. 63, Suppl.1 (2014), S177-S189. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR(CZ) GA305/09/0681; GA ČR(CZ) GAP304/12/0259; GA MŠMT(CZ) 7E10060
Institutional support: RVO:67985823
Keywords : cholinergic transmission * muscarinic receptors * therapy * Alzheimer's disease, * schizophrenia
Subject RIV: ED - Physiology
Impact factor: 1.293, year: 2014
Permanent Link: http://hdl.handle.net/11104/0233580 - 5.0427640 - FGÚ 2015 RIV US eng J - Journal Article
Šantrůčková, Eva - Doležal, Vladimír - El-Fakahany, E. E. - Jakubík, Jan
Long-Term Activation upon Brief Exposure to Xanomleline Is Unique to M1 and M4 Subtypes of Muscarinic Acetylcholine Receptors.
PLoS ONE. Roč. 9, č. 2 (2014), e88910. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR(CZ) GA305/09/0681; GA ČR(CZ) GAP304/12/0259
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : muscarinic receptors * functional selectivity * xanomeline
Subject RIV: ED - Physiology
Impact factor: 3.234, year: 2014
Permanent Link: http://hdl.handle.net/11104/0233140 - 6.0420861 - FGÚ 2014 RIV US eng J - Journal Article
Boulos, J. - Jakubík, Jan - Randáková, Alena - Avila, C.
Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications.
Journal of Heterocyclic Chemistry. Roč. 50, č. 6 (2013), s. 1363-1367. ISSN 0022-152X. E-ISSN 1943-5193
R&D Projects: GA ČR(CZ) GA305/09/0681
Institutional support: RVO:67985823
Keywords : N-piperidine substituted salts * muscarinic receptor antagonists * selectivity
Subject RIV: ED - Physiology
Impact factor: 0.873, year: 2013
Permanent Link: http://hdl.handle.net/11104/0227397 - 7.0398286 - FGÚ 2014 RIV NL eng J - Journal Article
Jakubík, Jan - Randáková, Alena - Doležal, Vladimír
On homology modeling of the M-2 muscarinic acetylcholine receptor subtype.
Journal of Computer-Aided Molecular Design. Roč. 27, č. 6 (2013), s. 525-538. ISSN 0920-654X. E-ISSN 1573-4951
R&D Projects: GA ČR(CZ) GA305/09/0681; GA ČR(CZ) GBP304/12/G069
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : muscarinic acetylcholine receptor * G-protein coupled receptor * homology energy estimation * MM-GBSA
Subject RIV: ED - Physiology
Impact factor: 2.782, year: 2013
Permanent Link: http://hdl.handle.net/11104/0225814 - 8.0393015 - FGÚ 2014 RIV NL eng J - Journal Article
Janíčková, Helena - Rudajev, Vladimír - Zimčík, Pavel - Jakubík, Jan - Tanila, H. - El-Fakahany, E. E. - Doležal, Vladimír
Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid beta(1-42).
Neuropharmacology. Roč. 67, April (2013), s. 272-283. ISSN 0028-3908. E-ISSN 1873-7064
R&D Projects: GA ČR(CZ) GA305/09/0681; GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) 7E10060
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : Alzheimer´s Disease * muscarinic receptors * G-proteins
Subject RIV: ED - Physiology
Impact factor: 4.819, year: 2013
Permanent Link: http://hdl.handle.net/11104/0221786 - 9.0370409 - FGÚ 2012 RIV US eng J - Journal Article
Jakubík, Jan - Janíčková, Helena - Randáková, Alena - El-Fakahany, E. E. - Doležal, Vladimír
Subtype Differences in Pre-Coupling of Muscarinic Acetylcholine Receptors.
PLoS ONE. Roč. 6, č. 11 (2011), e27732. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR(CZ) GA305/09/0681; GA AV ČR(CZ) IAA500110703; GA MŠMT(CZ) LC554
Institutional research plan: CEZ:AV0Z50110509
Keywords : acetylcholine muscarinic receptors * G proteins * subtype differences
Subject RIV: ED - Physiology
Impact factor: 4.092, year: 2011
Permanent Link: http://hdl.handle.net/11104/0204222 - 10.0359734 - FGÚ 2012 RIV GB eng J - Journal Article
Jakubík, Jan - Janíčková, Helena - El-Fakahany, E. E. - Doležal, Vladimír
Negative cooperativity in binding of muscarinic receptor agonists and GDP as a measure of agonist efficacy.
British Journal of Pharmacology. Roč. 162, č. 5 (2011), s. 1029-1044. ISSN 0007-1188. E-ISSN 1476-5381
R&D Projects: GA ČR(CZ) GA305/09/0681; GA AV ČR(CZ) IAA500110703; GA MŠMT(CZ) LC554
Institutional research plan: CEZ:AV0Z50110509
Keywords : acetylcholine * muscarinic receptor * GDP
Subject RIV: FH - Neurology
Impact factor: 4.409, year: 2011
Permanent Link: http://hdl.handle.net/11104/0197462