Search results
- 1.0330753 - ÚOCHB 2010 RIV US eng J - Journal Article
Grantz Šašková, Klára - Kožíšek, Milan - Řezáčová, Pavlína - Brynda, Jiří - Yashina, T. - Kagan, R. M. - Konvalinka, Jan
Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir.
Journal of Virology. Roč. 83, č. 17 (2009), s. 8810-8818. ISSN 0022-538X. E-ISSN 1098-5514
R&D Projects: GA MŠMT 1M0508
EU Projects: European Commission(XE) 37693 - HIV PI RESISTANCE
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50520514
Keywords : HIV-1 protease * darunavir * X-ray structural analysis * protease inhibitor * mutations
Subject RIV: CE - Biochemistry
Impact factor: 5.150, year: 2009
Permanent Link: http://hdl.handle.net/11104/0176467 - 2.0312673 - ÚOCHB 2009 RIV US eng J - Journal Article
Grantz Šašková, Klára - Kožíšek, Milan - Lepšík, Martin - Brynda, Jiří - Řezáčová, Pavlína - Václavíková, Jana - Kagan, R. M. - Machala, L. - Konvalinka, Jan
Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir.
[Enzymatická a strukturální charakterizace mutace I47A podílející se na snížšné citlivosti k HIV proteasovému inhibitoru lopinaviru.]
Protein Science. Roč. 17, č. 9 (2008), s. 1555-1564. ISSN 0961-8368. E-ISSN 1469-896X
R&D Projects: GA MŠMT 1M0508; GA MZd NR8571
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50520514
Keywords : HIV protease inhibitors * antiviral resistance development * X-ray structure * molecular recognition * enzyme kinetics
Subject RIV: CE - Biochemistry
Impact factor: 3.115, year: 2008
Permanent Link: http://hdl.handle.net/11104/0163672 - 3.0312664 - ÚOCHB 2009 RIV US eng J - Journal Article
Kožíšek, Milan - Grantz Šašková, Klára - Řezáčová, Pavlína - Brynda, Jiří - Maarseveen van, N. M. - De Jongh, D. - Boucher, Ch. A. B. - Kagan, R. M. - Nijhuis, M. - Konvalinka, Jan
Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region.
[Devadesát devět není dost : molekulární charakterizace resistentních mutantů HIV-1 proteasy s inzercemi v oblasti chlopní.]
Journal of Virology. Roč. 82, č. 12 (2008), s. 5869-5878. ISSN 0022-538X. E-ISSN 1098-5514
R&D Projects: GA MŠMT 1M0508; GA MZd NR8571
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50520514
Keywords : HIV protease inhibitors * aspartic proteases * viral resistance * insertions
Subject RIV: CE - Biochemistry
Impact factor: 5.308, year: 2008
Permanent Link: http://hdl.handle.net/11104/0163665