Search results
- 1.0572565 - ÚOCHB 2024 RIV US eng J - Journal Article
Skácel, Jan - Djukic, Stefan - Baszczyňski, Ondřej - Kalčic, Filip - Bílek, Tadeáš - Chalupský, Karel - Kozák, Jaroslav - Dvořáková, Alexandra - Tloušťová, Eva - Kráľová, Zuzana - Šmídková, Markéta - Voldřich, Jan - Rumlová, M. - Pachl, Petr - Brynda, Jiří - Vučková, Tereza - Fábry, Milan - Snášel, Jan - Pichová, Iva - Řezáčová, Pavlína - Mertlíková-Kaiserová, Helena - Janeba, Zlatko
Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors.
Journal of Medicinal Chemistry. Roč. 66, č. 10 (2023), s. 6652-6681. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA TA ČR(CZ) TN01000013; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : multisubstrate analog inhibitors * transition-state analog * human erythrocytes
OECD category: Organic chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.2c02097
Permanent Link: https://hdl.handle.net/11104/0343213File Download Size Commentary Version Access 10.1021acs.jmedchem.2c02097.pdf 1 5.7 MB Publisher’s postprint open-access - 2.0568174 - ÚOCHB 2024 RIV US eng J - Journal Article
Prener, Ladislav - Baszczyňski, Ondřej - Kaiser, Martin Maxmilian - Dračínský, Martin - Stepan, G. - Lee, Y. J. - Brumshtein, B. - Yu, H. - Jansa, P. - Lansdon, E. B. - Janeba, Zlatko
Design and Synthesis of Novel HIV-1 NNRTIs with Bicyclic Cores and with Improved Physicochemical Properties.
Journal of Medicinal Chemistry. Roč. 66, č. 3 (2023), s. 1761-1777. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:61388963
Keywords : reverse transcriptase inhibitors * wild type * optimization
OECD category: Organic chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.2c01574
Permanent Link: https://hdl.handle.net/11104/0339509 - 3.0553286 - ÚOCHB 2023 RIV US eng J - Journal Article
Khatun, M. - Kumar, K. - Baidya, A. - Mondal, R. K. - Baszczyňski, Ondřej - Kalčic, Filip - Banerjee, S. - Dhali, G. K. - Das, K. - Chowdhury, A. - Janeba, Zlatko - Chakrabarti, S. - Datta, S.
Variability in the Responses of Hepatitis B Virus D-Subgenotypes to Antiviral Therapy: Designing Pan-D-Subgenotypic Reverse Transcriptase Inhibitors.
Journal of Virology. Roč. 96, č. 2 (2022), č. článku e01800-21. ISSN 0022-538X. E-ISSN 1098-5514
Institutional support: RVO:61388963
Keywords : antiviral activity * entecavir * hepatitis B virus D-subgenotypes * high throughput virtual screening * phosphonate prodrug * zenofovir
OECD category: Organic chemistry
Impact factor: 5.4, year: 2022
Method of publishing: Limited access
https://doi.org/10.1128/JVI.01800-21
Permanent Link: http://hdl.handle.net/11104/0328267 - 4.0553163 - ÚOCHB 2023 RIV US eng J - Journal Article
Tichotová, Markéta - Ešnerová, A. - Tučková, Lucie - Bednárová, Lucie - Císařová, I. - Baszczyňski, Ondřej - Procházková, Eliška
31P NMR parameters may facilitate the stereochemical analysis of phosphorus-containing compounds.
Journal of Magnetic Resonance. Roč. 336, March (2022), č. článku 107149. ISSN 1090-7807. E-ISSN 1096-0856
R&D Projects: GA ČR(CZ) GA21-23014S
Institutional support: RVO:61388963
Keywords : circular dichroism spectroscopy * nuclear magnetic resonance spectroscopy * single crystals
OECD category: Analytical chemistry
Impact factor: 2.2, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.jmr.2022.107149
Permanent Link: http://hdl.handle.net/11104/0328166 - 5.0547506 - ÚOCHB 2022 RIV US eng J - Journal Article
Kalčic, Filip - Zgarbová, Michala - Hodek, Jan - Chalupský, Karel - Dračínský, Martin - Dvořáková, Alexandra - Strmeň, Timotej - Šebestík, Jaroslav - Baszczyňski, Ondřej - Weber, Jan - Mertlíková-Kaiserová, Helena - Janeba, Zlatko
Discovery of Modified Amidate (ProTide) Prodrugs of Tenofovir with Enhanced Antiviral Properties.
Journal of Medicinal Chemistry. Roč. 64, č. 22 (2021), s. 16425-16449. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT LTAUSA18086
Institutional support: RVO:61388963
Keywords : chemistry * drug development * drug effect
OECD category: Organic chemistry
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c01444
Permanent Link: http://hdl.handle.net/11104/0323727 - 6.0545329 - ÚOCHB 2022 RIV CH eng J - Journal Article
Dud, M. - Tichotová, Markéta - Procházková, Eliška - Baszczyňski, Ondřej
Phosphate-Based Self-Immolative Linkers for the Delivery of Amine-Containing Drugs.
Molecules. Roč. 26, č. 17 (2021), č. článku 5160. E-ISSN 1420-3049
R&D Projects: GA ČR(CZ) GA21-23014S
Institutional support: RVO:61388963
Keywords : 31P-NMR spectroscopy * amine-containing drugs * phosphate-based linkers * prodrugs * self-immolative linkers
OECD category: Analytical chemistry
Impact factor: 4.927, year: 2021
Method of publishing: Open access
https://doi.org/10.3390/molecules26175160
Permanent Link: http://hdl.handle.net/11104/0322051 - 7.0544662 - ÚOCHB 2022 RIV DE eng J - Journal Article
Šimon, P. - Tichotová, Markéta - Gallardo, M. G. - Procházková, Eliška - Baszczyňski, Ondřej
Phosphate-Based Self-Immolative Linkers for Tuneable Double Cargo Release.
Chemistry - A European Journal. Roč. 27, č. 50 (2021), s. 12763-12775. ISSN 0947-6539. E-ISSN 1521-3765
R&D Projects: GA ČR(CZ) GA21-23014S
Institutional support: RVO:61388963
Keywords : double cargo release * 31P NMR spectroscopy * phosphate linkers * photoactivation * self-immolation
OECD category: Analytical chemistry
Impact factor: 5.020, year: 2021
Method of publishing: Limited access
https://doi.org/10.1002/chem.202101805
Permanent Link: http://hdl.handle.net/11104/0321496 - 8.0542267 - ÚOCHB 2022 RIV US eng J - Journal Article
Keough, D. T. - Wun, J. S. - Baszczyňski, Ondřej - Eng, W. S. - Špaček, Petr - Panjikar, S. - Naesens, L. - Pohl, Radek - Rejman, Dominik - Hocková, Dana - Ferrero, R. L. - Guddat, L. W.
Helicobacter pylori Xanthine–Guanine–Hypoxanthine Phosphoribosyltransferase—A Putative Target for Drug Discovery against Gastrointestinal Tract Infections.
Journal of Medicinal Chemistry. Roč. 64, č. 9 (2021), s. 5710-5729. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR(CZ) GA19-07707S
Institutional support: RVO:61388963
Keywords : XGHPRT * inhibitor * phosphonate * nucleotide
OECD category: Organic chemistry
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.0c02184
Permanent Link: http://hdl.handle.net/11104/0319726 - 9.0533528 - ÚOCHB 2021 RIV US eng J - Journal Article
Dosoudil, P. - Kotek, V. - Kolman, Viktor - Baszczyňski, Ondřej - Kaiser, Martin Maxmilian - Janeba, Zlatko - Havránek, M.
Development of Scalable Synthesis of 5-Butyl-4-(4-methoxyphenyl)-6-phenylpyrimidin-2-amine (WQE-134), a Dual Inhibitor of Nitric Oxide and Prostaglandin E2 Production.
Organic Process Research & Development. Roč. 24, č. 9 (2020), s. 1718-1724. ISSN 1083-6160. E-ISSN 1520-586X
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963
Keywords : pyrimidines * Eaton’s reagent * upscale * C-acylation
OECD category: Organic chemistry
Impact factor: 3.317, year: 2020
Method of publishing: Limited access
https://doi.org/10.1021/acs.oprd.0c00324
Permanent Link: http://hdl.handle.net/11104/0312366 - 10.0518189 - ÚOCHB 2020 RIV GB eng J - Journal Article
Čechová, Lucie - Dejmek, Milan - Baszczyňski, Ondřej - Šaman, David - Gao, L. - Hu, E. - Stepan, G. - Jansa, P. - Janeba, Zlatko - Šimon, Petr
Synthesis and anti-human immunodeficiency virus activity of substituted (o,o-difluorophenyl)-linked-pyrimidines as potent non‐nucleoside reverse transcriptase inhibitors.
Antiviral Chemistry and Chemotherapy. Roč. 27, Feb 6 (2019), s. 1-18. ISSN 0956-3202
Institutional support: RVO:61388963
Keywords : diarylpyrimidine * human immunodeficiency virus * non-nucleoside reverse transcriptase inhibitor * etravirine * rilpivirine
OECD category: Organic chemistry
Method of publishing: Open access
https://journals.sagepub.com/doi/full/10.1177/2040206619826265
Permanent Link: http://hdl.handle.net/11104/0303424