Search results
- 1.0435073 - ÚOCHB 2015 RIV US eng J - Journal Article
Mládková, Jana - Hladílková, Jana - Diamond, C. E. - Tryon, K. - Yamada, K. - Garrow, T. A. - Jungwirth, Pavel - Koutmos, M. - Jiráček, Jiří
Specific potassium ion interactions facilitate homocysteine binding to betaine-homocysteine S-methyltransferase.
Proteins-Structure, Function and Bioinformatics. Roč. 82, č. 10 (2014), s. 2552-2564. ISSN 0887-3585. E-ISSN 1097-0134
R&D Projects: GA ČR(CZ) GAP207/10/1277; GA ČR GBP208/12/G016
Institutional support: RVO:61388963
Keywords : BHMT * homocysteine * potassium * crystal structure * molecular dynamics * simulations * enzyme kinetics
Subject RIV: CE - Biochemistry
Impact factor: 2.627, year: 2014
Permanent Link: http://hdl.handle.net/11104/0239271 - 2.0396069 - ÚOCHB 2014 RIV FR eng J - Journal Article
Pícha, Jan - Vaněk, Václav - Buděšínský, Miloš - Mládková, Jana - Garrow, T. A. - Jiráček, Jiří
The development of a new class of inhibitors for betaine-homocysteine S-methyltransferase.
European Journal of Medicinal Chemistry. Roč. 65, July (2013), s. 256-275. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GAP207/10/1277
Institutional support: RVO:61388963
Keywords : BHMT * inhibitor * homocysteine * phosphonate * phosphinate * amino acid derivative * bioisostere * S-alkylated homocysteine
Subject RIV: CE - Biochemistry
Impact factor: 3.432, year: 2013
Permanent Link: http://hdl.handle.net/11104/0223944 - 3.0394759 - ÚOCHB 2014 RIV NL eng J - Journal Article
Selicharová, Irena - Kořínek, M. - Demianova, Zuzana - Chrudinová, Martina - Mládková, Jana - Jiráček, Jiří
Effects of hyperhomocysteinemia and betaine-homocysteine S-methyltransferase inhibition on hepatocyte metabolites and the proteome.
Biochimica Et Biophysica Acta-Proteins and Proteomics. Roč. 1834, č. 8 (2013), s. 1596-1606. ISSN 1570-9639. E-ISSN 1878-1454
R&D Projects: GA ČR(CZ) GAP207/10/1277
Institutional support: RVO:61388963
Keywords : apolipoprotein * fibrinogen * one-carbon metabolism * S-Adenosylmethionine * two-dimensional electrophoresis
Subject RIV: CE - Biochemistry
Impact factor: 3.191, year: 2013
Permanent Link: http://hdl.handle.net/11104/0223106 - 4.0391512 - ÚOCHB 2014 RIV GB eng J - Journal Article
Kořínek, M. - Šístek, V. - Mládková, Jana - Mikeš, P. - Jiráček, Jiří - Selicharová, Irena
Quantification of homocysteine-related metabolites and the role of betaine-homocysteine S-methyltransferase in HepG2 cells.
Biomedical Chromatography. Roč. 27, č. 1 (2013), s. 111-121. ISSN 0269-3879. E-ISSN 1099-0801
R&D Projects: GA ČR(CZ) GAP207/10/1277
Institutional support: RVO:61388963
Keywords : homocysteine * BHMT * LC-MS/MS * HepG2 * metabolites
Subject RIV: CE - Biochemistry
Impact factor: 1.662, year: 2013
Permanent Link: http://hdl.handle.net/11104/0220544 - 5.0379825 - ÚOCHB 2013 RIV US eng J - Journal Article
Mládková, Jana - Vaněk, Václav - Buděšínský, Miloš - Elbert, Tomáš - Demianova, Zuzana - Garrow, T. A. - Jiráček, Jiří
Double-Headed Sulfur-Linked Amino Acids As First Inhibitors for Betaine-Homocysteine S-Methyltransferase 2.
Journal of Medicinal Chemistry. Roč. 55, č. 15 (2012), s. 6822-6831. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GA203/09/1919; GA ČR(CZ) GAP207/10/1277
Institutional support: RVO:61388963
Keywords : betaine * homocysteine * methionine * BHMT * inhibitor
Subject RIV: CE - Biochemistry
Impact factor: 5.614, year: 2012
Permanent Link: http://hdl.handle.net/11104/0210696 - 6.0347194 - ÚOCHB 2011 RIV GB eng J - Journal Article
Mládková, Jana - Šanda, Miloslav - Matoušková, E. - Selicharová, Irena
Phenotyping breast cancer cell lines EM-G3, HCC1937, MCF7 and MDA-MB-231 using 2-D electrophoresis and affinity chromatography for glutathione-binding proteins.
Bmc Cancer. Roč. 10, - (2010), 449/1-449/10. E-ISSN 1471-2407
R&D Projects: GA MŠMT(CZ) LC06077
Institutional research plan: CEZ:AV0Z40550506
Keywords : 2-DE * breast cancer * glutathione
Subject RIV: CC - Organic Chemistry
Impact factor: 3.153, year: 2010
http://www.biomedcentral.com/1471-2407/10/449
Permanent Link: http://hdl.handle.net/11104/0188026 - 7.0326968 - ÚOCHB 2010 RIV US eng J - Journal Article
Vaněk, Václav - Buděšínský, Miloš - Kabeleová, Petra - Šanda, Miloslav - Kožíšek, Milan - Hančlová, Ivona - Mládková, Jana - Brynda, Jiří - Rosenberg, Ivan - Koutmos, M. - Garrow, T. A. - Jiráček, Jiří
Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase.
Journal of Medicinal Chemistry. Roč. 52, č. 12 (2009), s. 3652-3665. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT 1M0508
Grant - others:GA MŠk(CZ) LC06077; NIH(US) R01TW0052501
Program: LC
Institutional research plan: CEZ:AV0Z40550506
Keywords : BHMT * betain * homocysteine * methionine * inhibitor
Subject RIV: CE - Biochemistry
Impact factor: 4.802, year: 2009
Permanent Link: http://hdl.handle.net/11104/0173885 - 8.0306927 - ÚOCHB 2008 RIV GR eng J - Journal Article
Selicharová, Irena - Šanda, Miloslav - Mládková, Jana - Ohri, S. S. - Vashishta, A. - Fusek, M. - Jiráček, Jiří - Vetvicka, V.
2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: Comparison with parental cell line MDA-MB-231.
[2-DE analýza buněčných linií 1833 a 4175 nádoru prsu s rozdílným potenciálem metastázovat do různých orgánů a srovnání s mateřskou buněčnou linií MDA-MB-231.]
Oncology Reports. Roč. 19, č. 5 (2008), s. 1237-1244. ISSN 1021-335X. E-ISSN 1791-2431
R&D Projects: GA MZd NR8323
Grant - others:NIH(US) ROI CAA082159-03
Institutional research plan: CEZ:AV0Z40550506
Keywords : breast cancer * cell line * 2-DE * organ-specific metastases
Subject RIV: CE - Biochemistry
Impact factor: 1.524, year: 2008
Permanent Link: http://hdl.handle.net/11104/0159822