Search results
- 1.0586002 - ÚOCHB 2025 RIV US eng J - Journal Article
Spiwoková, Petra - Horn, Martin - Fanfrlík, Jindřich - Jílková, Adéla - Fajtová, Pavla - Leontovyč, Adrian - Houštecká, Radka - Bieliková, Lucia - Brynda, Jiří - Chanová, M. - Mertlíková-Kaiserová, Helena - Diaz-Caro, E. J. E. - Almaliti, J. - El Sakkary, N. - Gerwick, W. H. - Caffrey, C. R. - Mareš, Michael
Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis.
ACS Infectious Diseases. Roč. 10, č. 6 (2024), s. 1935-1948. ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) LTAUSA19109; GA MŠMT(CZ) LUAUS23050; GA MZd(CZ) NV18-05-00345
Institutional support: RVO:61388963
Keywords : cathepsin B * cysteine protease * drug target * parasite * Schistosoma mansoni * acrylamide inhibitor
Impact factor: 5.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acsinfecdis.3c00589
Permanent Link: https://hdl.handle.net/11104/0353623 - 2.0561246 - ÚOCHB 2023 RIV DE eng J - Journal Article
Lemke, C. - Jílková, Adéla - Ferber, D. - Braune, A. - On, A. - Johe, P. - Zíková, Alena - Schirmeister, T. - Mareš, Michael - Horn, Martin - Gütschow, M.
Two Tags in One Probe: Combining Fluorescence- and Biotin-based Detection of the Trypanosomal Cysteine Protease Rhodesain.
Chemistry - A European Journal. Roč. 28, č. 62 (2022), č. článku e202201636. ISSN 0947-6539. E-ISSN 1521-3765
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : activity-based probes * affinity chromatography * cysteine proteases * imaging agents * peptidomimetics * rhodesain * size exclusion chromatography
OECD category: Biochemistry and molecular biology; Microbiology (BC-A)
Impact factor: 4.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/chem.202201636
Permanent Link: https://hdl.handle.net/11104/0333931 - 3.0545805 - ÚOCHB 2022 RIV US eng J - Journal Article
Lemke, C. - Benýšek, Jakub - Brajtenbach, D. - Breuer, C. - Jílková, Adéla - Horn, Martin - Buša, Michal - Ulrychová, Lenka - Illies, A. - Kubatzky, K. F. - Bartz, U. - Mareš, Michael - Gütschow, M.
An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity.
Journal of Medicinal Chemistry. Roč. 64, č. 18 (2021), s. 13793-13806. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : highly potent * vinyl sulfone * inhibitors
OECD category: Biochemistry and molecular biology
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c01178
Permanent Link: http://hdl.handle.net/11104/0322454 - 4.0540888 - ÚOCHB 2022 RIV US eng J - Journal Article
Jílková, Adéla - Rubešová, Petra - Fanfrlík, Jindřich - Fajtová, Pavla - Řezáčová, Pavlína - Brynda, Jiří - Lepšík, Martin - Mertlíková-Kaiserová, Helena - Emal, C. D. - Renslo, A. R. - Roush, W. R. - Horn, Martin - Caffrey, C. R. - Mareš, Michael
Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors.
ACS Infectious Diseases. Roč. 7, č. 5 (2021), s. 1077-1088. ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) LTAUSA19109; GA MŠMT(CZ) LH15040; GA MŠMT LO1302; GA MZd(CZ) NV18-05-00345; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LO1304
Institutional support: RVO:61388963
Keywords : cathepsin B * cysteine peptidase * drug target * parasite * Schistosoma mansoni * vinyl sulfone inhibitor
OECD category: Biochemistry and molecular biology
Impact factor: 5.578, year: 2021
Method of publishing: Open access
https://doi.org/10.1021/acsinfecdis.0c00501
Permanent Link: http://hdl.handle.net/11104/0318491 - 5.0538821 - ÚOCHB 2022 RIV US eng J - Journal Article
Jílková, Adéla - Horn, Martin - Fanfrlík, Jindřich - Küppers, J. - Pachl, Petr - Řezáčová, Pavlína - Lepšík, Martin - Fajtová, Pavla - Rubešová, Petra - Chanová, M. - Caffrey, C. R. - Gütschow, M. - Mareš, Michael
Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity.
ACS Infectious Diseases. Roč. 7, č. 1 (2021), s. 189-201. ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) LTAUSA19109; GA MZd(CZ) NV18-05-00345; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : azapeptide inhibitors * cysteine proteases * protein structures * structure-activity relationships * schistosomiasis
OECD category: Biochemistry and molecular biology
Impact factor: 5.578, year: 2021
Method of publishing: Open access
https://doi.org/10.1021/acsinfecdis.0c00644
Permanent Link: http://hdl.handle.net/11104/0316970 - 6.0490174 - ÚOCHB 2019 RIV CZ cze J - Journal Article
Jílková, Adéla - Horn, Martin - Mareš, Michael
Katepsin B1 parazitické krevničky: Molekulární cíl pro léčbu schistosomózy.
[Cathepsin B1 from the Human Blood Fluke: A Drug Target for Treatment of Schistosomiasis.]
Chemické listy. Roč. 112, č. 1 (2018), s. 3-9. ISSN 0009-2770. E-ISSN 1213-7103
R&D Projects: GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : cathepsin * protease * proteolysis * schistosoma * parasite * inhibitor
OECD category: Biochemistry and molecular biology
Impact factor: 0.311, year: 2018
http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/2960/2945
Permanent Link: http://hdl.handle.net/11104/0284461 - 7.0446340 - ÚOCHB 2016 RIV US eng J - Journal Article
Fajtová, Pavla - Štefanic, S. - Hradilek, Martin - Dvořák, Jan - Vondrášek, Jiří - Jílková, Adéla - Ulrychová, Lenka - McKerrow, J. H. - Caffrey, C. R. - Mareš, Michael - Horn, Martin
Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors.
PLoS Neglected Tropical Diseases. Roč. 9, č. 6 (2015), e0003827/1-e0003827/24. ISSN 1935-2735. E-ISSN 1935-2735
R&D Projects: GA ČR(CZ) GAP302/11/1481; GA MŠMT LO1302
Institutional support: RVO:61388963 ; RVO:68378050
Keywords : Schistosoma mansoni * schistosomiasis * prolyl oligopeptidase * blood fluke
Subject RIV: CE - Biochemistry; EB - Genetics ; Molecular Biology (UMG-J)
Impact factor: 3.948, year: 2015
http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003827
Permanent Link: http://hdl.handle.net/11104/0248346File Download Size Commentary Version Access 0446340.PDF 3 5.8 MB Publisher’s postprint open-access - 8.0438380 - ÚOCHB 2015 RIV GB eng J - Journal Article
Jílková, Adéla - Horn, Martin - Řezáčová, Pavlína - Marešová, Lucie - Fajtová, Pavla - Brynda, Jiří - Vondrášek, Jiří - McKerrow, J. H. - Caffrey, C. R. - Mareš, Michael
Activation Route of the Schistosoma mansoni Cathepsin B1 Drug Target: Structural Map with a Glycosaminoglycan Switch.
Structure. Roč. 22, č. 12 (2014), s. 1786-1798. ISSN 0969-2126. E-ISSN 1878-4186
R&D Projects: GA ČR GA203/09/1585; GA MŠMT LH12023; GA MŠMT LO1302
Institutional support: RVO:61388963 ; RVO:68378050
Keywords : human procathepsin B * slow binding inhibition * asparaginyl endopeptidase
Subject RIV: CE - Biochemistry
Impact factor: 5.618, year: 2014
Permanent Link: http://hdl.handle.net/11104/0241842 - 9.0429731 - ÚOCHB 2015 RIV CZ cze J - Journal Article
Horn, Martin - Jílková, Adéla - Mareš, Michael
Katepsinové proteasy v patologii.
[Cathepsin Proteases in Pathology.]
Chemické listy. Roč. 108, č. 4 (2014), s. 358-363. ISSN 0009-2770. E-ISSN 1213-7103
R&D Projects: GA ČR(CZ) GAP302/11/1481
Institutional support: RVO:61388963
Keywords : cathepsins * proteases * proteolysis
Subject RIV: CE - Biochemistry
Impact factor: 0.272, year: 2014
Permanent Link: http://hdl.handle.net/11104/0234802 - 10.0422118 - ÚOCHB 2014 RIV US eng J - Journal Article
Fanfrlík, Jindřich - Brahmkshatriya, Pathik - Řezáč, Jan - Jílková, Adéla - Horn, Martin - Mareš, Michael - Hobza, Pavel - Lepšík, Martin
Quantum Mechanics-Based Scoring Rationalizes the Irreversible Inactivation of Parasitic Schistosoma mansoni Cysteine Peptidase by Vinyl Sulfone Inhibitors.
Journal of Physical Chemistry B. Roč. 117, č. 48 (2013), s. 14973-14982. ISSN 1520-6106. E-ISSN 1520-5207
R&D Projects: GA ČR GBP208/12/G016; GA ČR GA203/09/1585; GA MŠMT LH12023
Grant - others:European Science Fund(XE) CZ.1.05/2.1.00/03.0058
Institutional support: RVO:61388963
Keywords : density-functional theory * protein-ligand * drug design
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 3.377, year: 2013
Permanent Link: http://hdl.handle.net/11104/0228354