Search results
- 1.0313507 - BTÚ 2009 RIV GB eng J - Journal Article
Dong, L.F. - Low, P. - Dyason, J.C. - Wang, X.-F. - Prochazka, L. - Witting, P.-K. - Freeman, R. - Swettenham, E. - Vališ, Karel - Liu, J. - Zobalová, Renata - Turanek, J. - Spitz, D.R. - Domann, F.E. - Scheffler, I.E. - Ralph, S.J. - Neužil, Jiří
alpha-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding.
[alfa-Tokoferylsukcinát indukuje apoptózu zasažením míst vázajících ubichinon v mitochondriálním respiračním komplexu II.]
Oncogene. Roč. 27, č. 31 (2008), s. 4324-4335. ISSN 0950-9232. E-ISSN 1476-5594
R&D Projects: GA AV ČR IAA500520702; GA AV ČR KAN200520703
Grant - others:GA MZe(CZ) MZE-0002716201
Institutional research plan: CEZ:AV0Z50520701
Keywords : Reactive oxygen species * apoptosis * anti-cancer drug target
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 7.216, year: 2008
Permanent Link: http://hdl.handle.net/11104/0164309 - 2.0096869 - ÚMG 2008 RIV AE eng J - Journal Article
Ralph, S.J. - Low, P. - Dong, L. - Lawen, A. - Neužil, Jiří
Mitocans: Mitochondrial targeted anti-cancer drugs as improved therapies and related patent documents.
[Mitokany: protirakovinné látky cílené k mitochondriím jakožto zlepšení terapie a související patentové dokumenty.]
Recent Patents on Anti-Cancer Drug Discovery. Roč. 1, - (2006), s. 327-346. ISSN 1574-8928. E-ISSN 2212-3970
Institutional research plan: CEZ:AV0Z50520514
Keywords : mitocans * vitamin E analogues * mitochondria-based targeting
Subject RIV: EB - Genetics ; Molecular Biology
Permanent Link: http://hdl.handle.net/11104/0156135 - 3.0096774 - ÚMG 2008 RIV US eng J - Journal Article
Neužil, Jiří - Tomasetti, M. - Zhao, Y. - Dong, L.F. - Birringer, M. - Wang, X. F. - Low, P. - Wu, K. - Salvatore, B.A. - Ralph, S.J.
Vitamin E analogs, a novel group of "mitocans," as anticancer agents: The importance of being redox-silent.
[Analogy vitaminu E, nová skupina mitokanů, jako protirakovinná léčiva: důležité být redox-neaktivní.]
Molecular Pharmacology. Roč. 71, č. 5 (2007), s. 1185-1199. ISSN 0026-895X. E-ISSN 1521-0111
Institutional research plan: CEZ:AV0Z50520514; CEZ:AV0Z50520701
Keywords : vitamin E analogs * redox-silence * anticancer drugs
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.622, year: 2007
Permanent Link: http://hdl.handle.net/11104/0156058 - 4.0096260 - ÚMG 2008 RIV US eng J - Journal Article
Dong, L.F. - Swettenham, E. - Eliasson, J. - Wang, X. F. - Gold, M. - Medunic, Y. - Stantic, M. - Low, P. - Procházka, L. - Witting, P. K. - Turánek, J. - Akporiaye, E.T. - Ralph, S.J. - Neužil, Jiří
Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating endothelial cells: the role of oxidative stress.
[Analogy vitaminu E inhibují angiogenezu selektivní indukcí apoptózy v proliferujících endoteliálních buňkách: role oxidativního stresu.]
Cancer Research. Roč. 67, č. 24 (2007), s. 11906-11913. ISSN 0008-5472. E-ISSN 1538-7445
R&D Projects: GA AV ČR KAN200520703; GA AV ČR IAA500520602
Institutional research plan: CEZ:AV0Z50520514; CEZ:AV0Z50520701
Keywords : mitocans * proliferating endothelial cells * apoptosis
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 7.672, year: 2007
Permanent Link: http://hdl.handle.net/11104/0155668 - 5.0081236 - ÚOCHB 2007 RIV US eng J - Journal Article
Wang, X. F. - Birringer, M. - Dong, L.F. - Vepřek, Pavel - Low, P. - Swettenham, E. - Stantic, M. - Yuan, L. H. - Zobalová, Renata - Wu, K. - Ledvina, Miroslav - Ralph, S.J. - Neužil, Jiří
A peptide conjugate of vitamin E succinate targets breast cancer cells with high erbB2 expression.
[Konjugát peptidu s vitamínem E specificky rozpoznává nádorové buňky prsu s vysokou expresí erbB2 receptoru.]
Cancer Research. Roč. 67, č. 7 (2007), s. 3337-3344. ISSN 0008-5472. E-ISSN 1538-7445
R&D Projects: GA MZe QF3115
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50520514
Keywords : vitamine E * erbB2 * breast cancer
Subject RIV: CC - Organic Chemistry
Impact factor: 7.672, year: 2007
Permanent Link: http://hdl.handle.net/11104/0145174 - 6.0051159 - ÚMG 2007 RIV GB eng J - Journal Article
Neužil, Jiří - Wang, X.F. - Dong, L.F. - Low, P. - Ralph, S.J.
Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins.
[Molekulární mechanismus apoptózy indukované ´mitokany´ v rakovinných buňkách shrnuje vícenásobnou roli reaktivních kyslíkových druhů a proteinů rodiny Bcl-2.]
FEBS Letters. Roč. 580, č. 22 (2006), s. 5125-5129. ISSN 0014-5793. E-ISSN 1873-3468
Institutional research plan: CEZ:AV0Z50520514
Keywords : mitocan * alpha-tocopheryl succinate * reactive oxygen species
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.372, year: 2006
Permanent Link: http://hdl.handle.net/11104/0141096