Search results
- 1.0579804 - ÚMG 2024 RIV US eng J - Journal Article
Mejdrova, I. - Dušek, J. - Škach, K. - Štefela, A. - Škoda, J. - Chalupský, Karel - Dohnalová, Klára - Pávková, I. - Kronenberger, T. - Rashidian, A. - Smutná, L. - Duchoslav, V. - Smutný, T. - Pávek, P. - Nencka, R.
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure.
Journal of Medicinal Chemistry. Roč. 66, č. 4 (2023), s. 2422-2456. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) LM2015040; GA ČR GA22-05167S; GA MŠMT ED2.1.00/19.0395
Institutional support: RVO:68378050
Keywords : pregnane-x-receptor * car * activation * pxr * ligand * derivatives * identification * artemisinin * metabolites * expression
OECD category: Cell biology
Impact factor: 6.8, year: 2023
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01140
Permanent Link: https://hdl.handle.net/11104/0348603 - 2.0569356 - ÚOCHB 2024 RIV US eng J - Journal Article
Mejdrová, Ivana - Dušek, J. - Škach, Kryštof - Štefela, A. - Škoda, J. - Chalupský, Karel - Dohnalová, K. - Pavková, I. - Kronenberger, T. - Rashidian, A. - Smutná, L. - Duchoslav, Vojtěch - Smutný, T. - Pávek, P. - Nencka, Radim
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure.
Journal of Medicinal Chemistry. Roč. 66, č. 4 (2023), s. 2422-2456. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA TA ČR(CZ) TN01000013
Institutional support: RVO:61388963
Keywords : pregnane X receptor * CAR * activation
OECD category: Pharmacology and pharmacy
Impact factor: 6.8, year: 2023
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.2c01140
Permanent Link: https://hdl.handle.net/11104/0340675
Research data: Zenodo - 3.0565349 - ÚOCHB 2024 RIV DE eng J - Journal Article
Díaz-Holguín, A. - Rashidian, A. - Pijnenburg, D. - Monteiro Ferreira, G. - Štefela, A. - Kašpar, Miroslav - Kudová, Eva - Poso, A. - van Beuningen, R. - Pávek, P. - Kronenberger, T.
When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists.
ChemMedChem. Roč. 18, č. 4 (2023), č. článku e202200556. ISSN 1860-7179. E-ISSN 1860-7187
Institutional support: RVO:61388963
Keywords : bile acids * molecular dynamics simulations * nuclear receptors * farnesoid X receptor
OECD category: Organic chemistry
Impact factor: 3.6, year: 2023
Method of publishing: Open access
https://doi.org/10.1002/cmdc.202200556
Permanent Link: https://hdl.handle.net/11104/0336902
Research data: Zenodo - 4.0556653 - ÚMG 2023 RIV US eng J - Journal Article
Škoda, J. - Dohnalová, Klára - Chalupský, Karel - Stahl, A. - Templin, M. - Maixnerova, J. - Mičuda, S. - Grontved, L. - Braeuning, A. - Pávek, P.
Off-target lipid metabolism disruption by the mouse constitutive androstane receptor ligand TCPOBOP in humanized mice.
Biochemical Pharmacology. Roč. 197, March (2022), č. článku 114905. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA ČR GA19-14497S
Institutional support: RVO:68378050
Keywords : Nuclear receptors * Endocrine disruptors * Drug interactions * Hepatotoxicity * Humanized mice (HuMice)
OECD category: Pharmacology and pharmacy
Impact factor: 5.8, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0006295221005311?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0330795 - 5.0545561 - ÚOCHB 2022 RIV CH eng J - Journal Article
Štefela, A. - Kašpar, Miroslav - Drastík, M. - Kronenberger, T. - Mičuda, S. - Dračínský, Martin - Klepetářová, Blanka - Kudová, Eva - Pávek, P.
(E)-7-Ethylidene-lithocholic Acid (7-ELCA) Is a Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimulating Glucagon-like Peptide-1 Secretion From Enteroendocrine Cells.
Frontiers in Pharmacology. Roč. 12, Aug 13 (2021), č. článku 713149. ISSN 1663-9812. E-ISSN 1663-9812
R&D Projects: GA TA ČR(CZ) TN01000013
Institutional support: RVO:61388963
Keywords : G protein-coupled bile acid receptor 1 * bile acids * steroid * farnesoid X receptor * metabolism
OECD category: Organic chemistry
Impact factor: 5.988, year: 2021
Method of publishing: Open access
https://doi.org/10.3389/fphar.2021.713149
Permanent Link: http://hdl.handle.net/11104/0322249 - 6.0543092 - MBÚ 2022 RIV NL eng J - Journal Article
Vinarov, Z. - Abrahamsson, B. - Artursson, P. - Batchelor, H. - Berben, P. - Bernkop-Schnurch, A. - Butler, J. - Ceulemans, J. - Davies, N. - Dupont, D. - Flaten, G. E. - Fotaki, N. - Griffin, B. T. - Jannin, V. - Keemink, J. - Kesisoglou, F. - Koziolek, M. - Kuentz, M. - Mackie, A. - Melendez-Martinez, A. J. - McAllister, M. - Mullertz, A. - O'Driscoll, C. M. - Parrott, N. - Paszkowska, J. - Pávek, P. - Porter, C. J. H. - Reppas, C. - Stillhart, C. - Sugano, K. - Toader, E. - Valentová, Kateřina - Vertzoni, M. - De Wildt, S. N. - Wilson, C. G. - Augustijns, P.
Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network.
Advanced Drug Delivery Reviews. Roč. 171, APR 2021 (2021), s. 289-331. ISSN 0169-409X. E-ISSN 1872-8294
R&D Projects: GA MŠMT(CZ) LTC19039; GA MŠMT(CZ) LTC18003; GA ČR(CZ) GA18-00132S
Institutional support: RVO:61388971
Keywords : Specific patient populations * Regional differences * Advanced formulations * Amorphous solid dispersions * Lipid-based formulations * Food-drug interactions * Microbiome * In vitro tools * PBPK modeling
OECD category: Pharmacology and pharmacy
Impact factor: 17.873, year: 2021
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S0169409X21000351?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0320380 - 7.0539733 - ÚMG 2021 RIV CH eng J - Journal Article
Škoda, J. - Dušek, J. - Drastík, M. - Štefela, A. - Dohnalová, Klára - Chalupský, Karel - Smutný, T. - Mičuda, S. - Gerbal-Chaloin, S. - Pávek, P.
Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain.
Cells. Roč. 9, č. 12 (2020), č. článku 2532. ISSN 2073-4409. E-ISSN 2073-4409
R&D Projects: GA ČR GA19-14497S; GA MŠMT(CZ) LM2018126; GA MŠMT ED2.1.00/19.0395
Institutional support: RVO:68378050
Keywords : diazepam * gene regulation * car * cytochrome P450 * drug interaction
OECD category: Biochemistry and molecular biology
Impact factor: 6.600, year: 2020
Method of publishing: Open access
https://www.mdpi.com/2073-4409/9/12/2532
Permanent Link: http://hdl.handle.net/11104/0317435 - 8.0531548 - ÚOCHB 2021 RIV GB eng J - Journal Article
Štefela, A. - Kašpar, Miroslav - Drastík, M. - Holas, O. - Hroch, M. - Smutný, T. - Škoda, J. - Hutníková, M. - Pandey, A. V. - Mičuda, S. - Kudová, Eva - Pávek, P.
3β-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3α-epimer by hepatic metabolism.
Journal of Steroid Biochemistry and Molecular Biology. Roč. 202, Sep (2020), č. článku 105702. ISSN 0960-0760. E-ISSN 1879-1220
R&D Projects: GA TA ČR(CZ) TN01000013
Institutional support: RVO:61388963
Keywords : nuclear receptors * bile acids * pharmacokinetics * gene regulation * metabolism
OECD category: Pharmacology and pharmacy
Impact factor: 4.294, year: 2020
Method of publishing: Limited access
https://doi.org/10.1016/j.jsbmb.2020.105702
Permanent Link: http://hdl.handle.net/11104/0310180 - 9.0505681 - MBÚ 2020 RIV NL eng J - Journal Article
Koziolek, M. - Alcaro, S. - Augustijns, P. - Basit, A.W. - Grimm, M. - Hens, B . - Hoad, C. - Jedamzik, P. - Madla, Ch.M. - Maliepaard, M. - Marciani, L. - Maruca, A. - Parrott, N. - Pávek, P. - Porter, Ch.J.H. - Reppas, Ch. - van Riet-Nales, D. - Rubbens, J. - Statelova, M. - Trevaskis, N.L. - Valentová, Kateřina - Vertzoni, M. - Cepo, D.V. - Corsetti, M.
The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group.
European Journal of Pharmaceutical Sciences. Roč. 134, JUN 15 (2019), s. 31-59. ISSN 0928-0987. E-ISSN 1879-0720
R&D Projects: GA ČR(CZ) GA18-00132S
Institutional support: RVO:61388971
Keywords : Food-drug interaction * Food effect * Oral drug delivery
OECD category: Pharmacology and pharmacy
Impact factor: 3.616, year: 2019
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S0928098719301411?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0297097 - 10.0477884 - ÚI 2018 CZ eng J - Journal Article
Smutný, T. - Duintjer Tebbens, Jurjen - Pávek, P.
Bioinformatic analysis of miRNAs targeting the key nuclear receptors regulating CYP3A4 gene expression: The challenge of the CYP3A4 "missing heritability'' enigma.
Journal of Applied Biomedicine. Roč. 13, č. 3 (2015), s. 181-188. ISSN 1214-021X. E-ISSN 1214-0287
Keywords : pregnane x receptor * microrna binding-sites * vitamin-d-receptor * transcriptional regulation * human liver * cytochrome-p450 3a4 * human hepatocytes * factor 4-alpha * in-silico * identification * miRNA * Gene regulation * cyp3a4 * Cytochrome P450 * Metabolism
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 1.509, year: 2015
Permanent Link: http://hdl.handle.net/11104/0274103