Search results
- 1.0584812 - BTÚ 2025 RIV US eng J - Journal Article
Sychra, T. - Spalenkova, A. - Balatka, S. - Václavíková, R. - Šeborová, K. - Ehrlichová, M. - Truksa, Jaroslav - Sandoval-Acuna, Cristian - Němcová, V. - Szabo, A. - Kočí, K. - Tesarova, T. - Chen, L. - Ojima, I. - Oliverius, M. - Souček, P.
Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinoma.
iScience. Roč. 27, č. 2 (2024), č. článku 109044. E-ISSN 2589-0042
R&D Projects: GA ČR(CZ) GA21-14082S
Institutional support: RVO:86652036
Keywords : biological evaluation * cancer * microenvironment * cytotoxicity * transport * design
OECD category: Biochemistry and molecular biology
Impact factor: 5.8, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S2589004224002657?via%3Dihub
Permanent Link: https://hdl.handle.net/11104/0352753 - 2.0565763 - BTÚ 2023 RIV CH eng J - Journal Article
Šeborová, K. - Koucká, K. - Spalenkova, A. - Holý, P. - Ehrlichová, M. - Sychra, T. - Chen, L. - Bendale, H. - Ojima, I. - Sandoval-Acuna, Cristian - Truksa, Jaroslav - Souček, P. - Václavíková, R.
Anticancer regimens containing third generation taxanes SB-T-121605 and SB-T-121606 are highly effective in resistant ovarian carcinoma model.
Frontiers in Pharmacology. Roč. 13, NOV 9 2022 (2022), č. článku 971905. ISSN 1663-9812. E-ISSN 1663-9812
R&D Projects: GA ČR(CZ) GA21-14082S
Institutional support: RVO:86652036
Keywords : ovarian carcinoma * resistance * paclitaxel * SB-T taxanes * efficacy * in vitro * in vivo
OECD category: Pharmacology and pharmacy
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fphar.2022.971905/full
Permanent Link: https://hdl.handle.net/11104/0337429 - 3.0490321 - ÚOCHB 2019 RIV US eng J - Journal Article
Jelínek, M. - Balušíková, K. - Daniel, P. - Němcová-Fürstová, V. - Palani, Kirubakaran - Jaček, M. - Wei, L. - Wang, X. - Vondrášek, Jiří - Ojima, I. - Kovář, J.
Substituents at the C3' and C3'N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel.
Toxicology and Applied Pharmacology. Roč. 347, May 15 (2018), s. 79-91. ISSN 0041-008X. E-ISSN 1096-0333
Institutional support: RVO:61388963
Keywords : taxane derivates * acquired resistance to paclitaxel * breast cancer cells * ABCB1 transporter * molecular docking
OECD category: Biochemistry and molecular biology
Impact factor: 3.585, year: 2018
Permanent Link: http://hdl.handle.net/11104/0284952 - 4.0380490 - ÚI 2013 RIV DE eng J - Journal Article
Ehrlichová, M. - Ojima, I. - Chen, J. - Václavíková, R. - Němcová-Fürstová, V. - Vobořilová, J. - Šimek, Petr - Horský, S. - Souček, P. - Kovář, J. - Brabec, Marek - Gut, I.
Transport, metabolism, cytotoxicity and effects of novel taxanes on the cell cycle in MDA-MB-435 and NCI/ADR-RES cells.
Naunyn-Schmiedeberg's Archives of Pharmacology. Roč. 385, č. 10 (2012), s. 1035-1048. ISSN 0028-1298. E-ISSN 1432-1912
R&D Projects: GA MZd(CZ) NT11513
Grant - others:GA MZd(CZ) NS9803; GA ČR(CZ) GA301/09/0362
Institutional research plan: CEZ:AV0Z10300504; CEZ:AV0Z50070508
Keywords : taxanes * multidrug resistance * transport * drug metabolism * ABC transporters * cell cycle
Subject RIV: EB - Genetics ; Molecular Biology; BB - Applied Statistics, Operational Research (UIVT-O)
Impact factor: 2.147, year: 2012
Permanent Link: http://hdl.handle.net/11104/0211186 - 5.0333896 - ÚMG 2010 RIV GR eng J - Journal Article
Kovář, J. - Ehrlichová, M. - Šmejkalová, Barbora - Zanardi, I. - Ojima, I. - Gut, I.
Comparison of cell death-inducing effect of novel taxane SB-T-1216 and paclitaxel in breast cancer cells.
Anticancer Research. Roč. 29, č. 8 (2009), s. 2951-2960. ISSN 0250-7005. E-ISSN 1791-7530
R&D Projects: GA ČR(CZ) GD204/05/H023
Grant - others:GA MZd(CZ) NR9426; GA ČR(CZ) GA301/09/0362
Institutional research plan: CEZ:AV0Z50520514
Keywords : Cell death * taxane SB-T-1216 * paclitaxel
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 1.428, year: 2009
Permanent Link: http://hdl.handle.net/11104/0178771 - 6.0044557 - BC 2007 RIV GB eng J - Journal Article
Gut, I. - Ojima, I. - Václavíková, R. - Šimek, Petr - Horský, S. - Linhart, I. - Souček, P. - Kondrová, E. - Kuznetsova, L.V. - Chen, J.
Metabolism of new-generation taxanes in human, pig, minipig and rat liver microsomes.
[Metabolismus nové generace taxanů v lidských, prasečích, miniprasečích a krysích mikrosomech.]
Xenobiotica. Roč. 36, č. 9 (2006), s. 772-792. ISSN 0049-8254. E-ISSN 1366-5928
R&D Projects: GA ČR(CZ) GA305/04/0403
Institutional research plan: CEZ:AV0Z50070508
Keywords : novel taxanes * cytochrome P450 (CYP) * CYP3A orthologues
Subject RIV: ED - Physiology
Impact factor: 1.613, year: 2006
Permanent Link: http://hdl.handle.net/11104/0137304 - 7.0027660 - ÚMG 2006 RIV DE eng J - Journal Article
Ehrlichová, Marie - Václavíková, R. - Ojima, I. - Pepe, A. - Kuznetsova, L.V. - Chen, J. - Truksa, Jaroslav - Kovář, Jan - Gut, I.
Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells.
[Transport a cytotoxicita paclitaxelu, docetaxelu a nových taxanů u lidských buněk nádorů prsu.]
Naunyn-Schmiedeberg's Archives of Pharmacology. Roč. 372, č. 1 (2005), s. 95-105. ISSN 0028-1298. E-ISSN 1432-1912
R&D Projects: GA MZd(CZ) NL7567; GA ČR(CZ) GA305/04/0403
Institutional research plan: CEZ:AV0Z50520514; CEZ:AV0Z5052915
Keywords : taxanes * uptake * ABC transporters
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.098, year: 2005
Permanent Link: http://hdl.handle.net/11104/0117728