Search results
- 1.0584427 - FGÚ 2025 RIV GB eng J - Journal Article
Cheema, Marie Munawar - Kotrbová Macáková, Zuzana - Hrčka Krausová, Barbora - Adla, Santosh Kumar - Slavíková, Barbora - Chodounská, Hana - Kratochvíl, Miroslav - Vondrášek, Jiří - Sedlák, David - Balaštík, Martin - Kudová, Eva
5β-reduced neuroactive steroids as modulators of growth and viability of postnatal neurons and glia.
Journal of Steroid Biochemistry and Molecular Biology. Roč. 239, May (2024), č. článku 106464. ISSN 0960-0760
R&D Projects: GA MŠMT(CZ) LX22NPO5107; GA MZd(CZ) NV18-04-00085; GA ČR(CZ) GA21-24571S
Research Infrastructure: CZ-OPENSCREEN III - 90130; CZ-OPENSCREEN II - 90063; CCP II - 90126
Institutional support: RVO:67985823 ; RVO:61388963 ; RVO:68378050
Keywords : neurosteroids * neuroactive steroids * neurite growth * computational analysis * myelin basic protein * high-content screening
OECD category: Clinical neurology
Impact factor: 4.1, year: 2022
https://doi.org/10.1016/j.jsbmb.2024.106464
Permanent Link: https://hdl.handle.net/11104/0352546 - 2.0567469 - ÚMG 2023 RIV CH eng J - Journal Article
Součková, O. - Škopová, V. - Barešová, V. - Sedlák, David - Bleyer, A. J. - Kmoch, S. - Zikánová, M.
Metabolites of De Novo Purine Synthesis: Metabolic Regulators and Cytotoxic Compounds.
Metabolites. Roč. 12, č. 12 (2022), č. článku 1210. E-ISSN 2218-1989
R&D Projects: GA MŠMT(CZ) LM2018130
Research Infrastructure: NCMG II - 90132
Institutional support: RVO:68378050
Keywords : purine synthesis * pfas * paics * adsl * atic * cytotoxicity * fgar * air * saicar * aicar
OECD category: Biochemistry and molecular biology
Impact factor: 4.1, year: 2022
Method of publishing: Open access
https://www.mdpi.com/2218-1989/12/12/1210
Permanent Link: https://hdl.handle.net/11104/0338718 - 3.0566015 - ÚMG 2023 RIV US eng J - Journal Article
Ryšánek, David - Vašicová, Pavla - Kolla, Jayaprakash Narayana - Sedlák, David - Anděra, Ladislav - Bártek, Jiří - Hodný, Zdeněk
Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells.
Aging. Roč. 14, č. 16 (2022), s. 6381-6414. ISSN 1945-4589
R&D Projects: GA MŠMT(CZ) LM2018129; GA MŠMT(CZ) EF18_046/0016045; GA ČR(CZ) GA18-14259S; GA MŠMT(CZ) LM2018130; GA MŠMT LX22NPO5102
Institutional support: RVO:68378050
Keywords : homoharringtonine * cellular senescence * bcl-2 * mcl-1 * senolytics
OECD category: Cell biology
Impact factor: 5.2, year: 2022
Method of publishing: Open access
https://www.aging-us.com/article/204207/text
Permanent Link: https://hdl.handle.net/11104/0337451File Download Size Commentary Version Access aging-v14i16-204207.pdf 1 8.5 MB Publisher’s postprint open-access - 4.0564793 - BC 2023 RIV US eng J - Journal Article
Tůmová, Šárka - Miláček, Matěj - Šnajdr, Ivan - Muthu, Magesh - Tůma, R. - Řeha, D. - Jedlička, Pavel - Bittová, Lenka - Novotná, Adéla - Majer, Pavel - Sedlák, David - Jindra, Marek
Unique peptidic agonists of a juvenile hormone receptor with species-specific effects on insect development and reproduction.
Proceedings of the National Academy of Sciences of the United States of America. Roč. 119, č. 48 (2022), č. článku e2215541119. ISSN 0027-8424. E-ISSN 1091-6490
R&D Projects: GA ČR(CZ) GX20-05151X; GA MŠMT(CZ) LM2018130
Institutional support: RVO:60077344 ; RVO:61388963 ; RVO:68378050
Keywords : hormone receptor * juvenile hormone * ligand-binding pocket
OECD category: Biochemistry and molecular biology; Biochemistry and molecular biology (UOCHB-X); Biochemistry and molecular biology (UMG-J)
Impact factor: 11.1, year: 2022
Method of publishing: Limited access
https://www.pnas.org/doi/epdf/10.1073/pnas.2215541119
Permanent Link: https://hdl.handle.net/11104/0336446 - 5.0555482 - ÚMG 2022 RIV US eng J - Journal Article
Sedlák, David - Wilson, T.A. - Tjarks, W. - Radomska, H.S. - Wang, H. - Kolla, Jayaprakash Narayana - Lesnikowski, Z. J. - Spicakova, A. - Ali, T. - Ishita, K. - Rakotondraibe, L.H. - Vibhute, S. - Wang, D. - Anzenbacher, P. - Bennett, C. - Bartůněk, Petr - Coss, C.C.
Structure-Activity Relationship of para-Carborane Selective Estrogen Receptor beta Agonists.
Journal of Medicinal Chemistry. Roč. 64, č. 13 (2021), s. 9330-9353. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT LM2015063; GA MŠMT(CZ) LM2018130
Research Infrastructure: CZ-OPENSCREEN II - 90063
Institutional support: RVO:68378050
Keywords : neutron-capture therapy * boron clusters * g-protein * ligands * design * alpha * prostate * bearing * potent * disruption
OECD category: Biochemistry and molecular biology
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00555
Permanent Link: http://hdl.handle.net/11104/0329993 - 6.0553487 - MBÚ 2023 RIV DE eng J - Journal Article
Delawská, Kateřina - Divoká, Petra - Sedlák, David - Kuzma, Marek - Saurav, Kumar - Macho, Markéta - Steinbach, G. - Hrouzek, Pavel
New Insights into Tolytoxin Effect in Human Cancer Cells: Apoptosis Induction and the Relevance of Hydroxyl Substitution of Its Macrolide Cycle on Compound Potency.
Chembiochem. Roč. 23, č. 1 (2022), č. článku e202100489. ISSN 1439-4227. E-ISSN 1439-7633
R&D Projects: GA ČR(CZ) GF21-05649K; GA MŠMT(CZ) LO1416; GA MŠMT(CZ) LM2018130
EU Projects: European Commission(XE) Interreg 41 Czech-Bavaria
Institutional support: RVO:61388971 ; RVO:68378050
Keywords : actin * binding * scytophycins * agents * actin disruption * apoptosis * cancer * scytophycines * tolytoxin
OECD category: Biochemistry and molecular biology
Impact factor: 3.2, year: 2022
Method of publishing: Limited access
https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cbic.202100489
Permanent Link: http://hdl.handle.net/11104/0330344 - 7.0548866 - BTÚ 2022 RIV GB eng J - Journal Article
Švecová, Leona - Ostergaard, L. H. - Skálová, Tereza - Schnorr, K. M. - Koval, Tomáš - Kolenko, Petr - Stránský, Jan - Sedlák, David - Dušková, Jarmila - Trundová, Mária - Hašek, Jindřich - Dohnálek, Jan
Crystallographic fragment screening-based study of a novel FAD-dependent oxidoreductase from Chaetomium thermophilum.
Acta Crystallographica Section D-Structural Biology. Roč. 77, JUN 1 2021 (2021), s. 755-775. ISSN 2059-7983. E-ISSN 2059-7983
R&D Projects: GA MŠMT(CZ) ED1.1.00/02.0109; GA MŠMT EF15_003/0000447; GA MŠMT LM2015063; GA MŠMT(CZ) LM2018130
Research Infrastructure: CZ-OPENSCREEN II - 90063; CZ-OPENSCREEN III - 90130
Institutional support: RVO:86652036 ; RVO:68378050
Keywords : FAD-dependent oxidoreductases * GMC oxidoreductases * Chaetomium thermophilum
OECD category: Biochemical research methods
Impact factor: 5.699, year: 2021
Method of publishing: Open access
https://scripts.iucr.org/cgi-bin/paper?S2059798321003533
Permanent Link: http://hdl.handle.net/11104/0327304 - 8.0522814 - ÚMG 2020 RIV GB eng J - Journal Article
Pelet, A. - Škopová, V. - Steuerwald, U. - Barešová, V. - Zarhrate, M. - Plaza, J. - M. - Hnízda, A. - Krijt, M. - Součková, O. - Wibrand, F. - Andorsdottir, G. - Joensen, F. - Sedlák, David - Bleyer, A. J. - Kmoch, S. - Lyonnet, S. - Zikanov, M.
PAICS deficiency, a new defect of de novo purine synthesis resulting in multiple congenital anomalies and fatal outcome.
Human Molecular Genetics. Roč. 28, č. 22 (2019), s. 3805-3814. ISSN 0964-6906. E-ISSN 1460-2083
R&D Projects: GA MŠMT(CZ) LQ1604; GA MŠMT LM2015063
Institutional support: RVO:68378050
Keywords : aica-ribosiduria * adenylosuccinate * mutations * ribotide * adsl
OECD category: Genetics and heredity (medical genetics to be 3)
Impact factor: 5.101, year: 2019
Method of publishing: Limited access
https://academic.oup.com/hmg/article/28/22/3805/5584440
Permanent Link: http://hdl.handle.net/11104/0307242 - 9.0510440 - ÚMG 2020 RIV GB eng J - Journal Article
Pavlickova, V. - Jurásek, M. - Rimpelová, S. - Záruba, K. - Sedlák, David - Šimková, M. - Kodr, D. - Staňková, E. - Fahnrich, J. - Rottnerová, Z. - Bartůněk, Petr - Lapčík, O. - Drasar, P. - Ruml, T.
Oxime-based 19-nortestosterone-pheophorbide a conjugate: bimodal controlled release concept for PDT.
Journal of Materials Chemistry B. Roč. 7, č. 36 (2019), s. 5465-5477. ISSN 2050-750X. E-ISSN 2050-7518
R&D Projects: GA MŠMT LO1220; GA MŠMT LM2015063; GA MŠMT(CZ) LO1304
Institutional support: RVO:68378050
Keywords : human breast-cancer * mediated photodynamic therapy * androgen-receptor * prostate-cancer * in-vitro * biological evaluation * pyropheophorbide-a * cellular uptake * pheophorbide * photosensitizers
OECD category: Cell biology
Impact factor: 5.344, year: 2019
Method of publishing: Limited access
https://pubs.rsc.org/en/content/articlelanding/2019/TB/C9TB01301F#!divAbstract
Permanent Link: http://hdl.handle.net/11104/0306733 - 10.0502619 - ÚMG 2020 CZ cze J - Journal Article
Popr, Martin - Sedlák, David - Bartůněk, Petr
Compound Management – správa knihoven chemických látek pro testování biologické aktivity s vysokou propustností.
[Compound Management – Maintenance of Chemical Compound Libraries for Use in High Throughput Screening.]
Chemické listy. Roč. 111, č. 11 (2017), s. 772-776. ISSN 0009-2770. E-ISSN 1213-7103
R&D Projects: GA MŠMT LO1220
Institutional support: RVO:68378050
Keywords : Compound Management, , , , , ,, * High Throughput Screening * laboratory automation * reformatting * chemical biology * liquid handling * sample storage * DMSO
OECD category: Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Impact factor: 0.260, year: 2017
Permanent Link: http://hdl.handle.net/11104/0294514