Search results
- 1.0504453 - FGÚ 2020 RIV GB eng J - Journal Article
Jakubík, Jan - Randáková, Alena - Rudajev, Vladimír - Zimčík, Pavel - El-Fakahany, E. E. - Doležal, Vladimír
Applications and limitations of fitting of the operational model to determine relative efficacies of agonists.
Scientific Reports. Roč. 9, Mar 15 (2019), č. článku 4637. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR(CZ) GA17-16182S
Institutional support: RVO:67985823
Keywords : operational model of agonism * affinity * efficacy
OECD category: Physiology (including cytology)
Impact factor: 3.998, year: 2019
Method of publishing: Open access
https://doi.org/10.1038/s41598-019-40993-w
Permanent Link: http://hdl.handle.net/11104/0296081 - 2.0490235 - FGÚ 2019 RIV GB eng J - Journal Article
Randáková, Alena - Rudajev, Vladimír - Doležal, Vladimír - Boulos, J. - Jakubík, Jan
Novel long‐acting antagonists of muscarinic ACh receptors.
British Journal of Pharmacology. Roč. 175, č. 10 (2018), s. 1731-1743. ISSN 0007-1188. E-ISSN 1476-5381
R&D Projects: GA ČR(CZ) GA17-16182S
Institutional support: RVO:67985823
Keywords : muscarinic acetylcholine receptors * long-acting antagonists * tetrahydropyridinium slats
OECD category: Physiology (including cytology)
Impact factor: 6.583, year: 2018
Permanent Link: http://hdl.handle.net/11104/0284504 - 3.0489273 - FGÚ 2019 RIV NL eng J - Journal Article
Randáková, Alena - Dolejší, Eva - Rudajev, Vladimír - Zimčík, Pavel - Doležal, Vladimír - El-Fakahany, E. E. - Jakubík, Jan
Role of membrane cholesterol in differential sensitivity of muscarinic receptor subtypes to persistently bound xanomeline.
Neuropharmacology. Roč. 133, May 1 (2018), s. 129-144. ISSN 0028-3908. E-ISSN 1873-7064
R&D Projects: GA ČR(CZ) GA14-05696S; GA ČR(CZ) GA17-16182S
Institutional support: RVO:67985823
Keywords : muscarinic acetylcholine receptors * membrane cholesterol * xanomeline * receptor activation * molecular dynamics
OECD category: Physiology (including cytology)
Impact factor: 4.367, year: 2018
Permanent Link: http://hdl.handle.net/11104/0283716 - 4.0456635 - FGÚ 2016 RIV US eng J - Journal Article
Dolejší, Eva - Liraz, O. - Rudajev, Vladimír - Zimčík, Pavel - Doležal, Vladimír - Michaelson, D. M.
Apolipoprotein E4 reduces evoked hippocampal acetylcholine release in adult mice.
Journal of Neurochemistry. Roč. 136, č. 3 (2016), s. 503-509. ISSN 0022-3042. E-ISSN 1471-4159
R&D Projects: GA MŠMT(CZ) LH13269
Institutional support: RVO:67985823
Keywords : acetylcholine release * Alzheimer's disease (AD) * apolipoprotein E4 (apoE4) * hippocampus
Subject RIV: FH - Neurology
Impact factor: 4.083, year: 2016
Permanent Link: http://hdl.handle.net/11104/0257140 - 5.0454411 - FGÚ 2016 RIV NL eng J - Journal Article
Janíčková, Helena - Rudajev, Vladimír - Dolejší, Eva - Koivisto, H. - Jakubík, Jan - Tanila, H. - El-Fakahany, E. E. - Doležal, Vladimír
Lipid-Based Diets Improve Muscarinic Neurotransmission in the Hippocampus of Transgenic APPswe/PS1dE9 Mice.
Current Alzheimer Research. Roč. 12, č. 10 (2015), s. 923-931. ISSN 1567-2050. E-ISSN 1875-5828
R&D Projects: GA MŠMT(CZ) 7E10060; GA MŠMT(CZ) EE2.3.30.0025
Institutional support: RVO:67985823
Keywords : G-protein activation * hippocampus * muscarinic neurotransmission * nutrition * omega-3 fatty acids * stigmasterol
Subject RIV: FH - Neurology
Impact factor: 3.145, year: 2015
Permanent Link: http://hdl.handle.net/11104/0255091 - 6.0448654 - FGÚ 2016 RIV GB eng J - Journal Article
Randáková, Alena - Dolejší, Eva - Rudajev, Vladimír - Zimčík, Pavel - Doležal, Vladimír - El-Fakahany, E. E. - Jakubík, Jan
Classical and atypical agonists activate M1 muscarinic acetylcholine receptors through common mechanisms.
Pharmacological Research. Roč. 97, Jul 2015 (2015), s. 27-39. ISSN 1043-6618. E-ISSN 1096-1186
R&D Projects: GA ČR(CZ) GA305/09/0681; GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) EE2.3.30.0025
Institutional support: RVO:67985823
Keywords : muscarinic acetylcholine receptors * atypical agonists * xanomeline * activation mechanism
Subject RIV: ED - Physiology
Impact factor: 4.816, year: 2015
Permanent Link: http://hdl.handle.net/11104/0250288 - 7.0447525 - FGÚ 2016 RIV US eng J - Journal Article
Roubalová, Lenka - Vošahlíková, Miroslava - Brejchová, Jana - Sýkora, Jan - Rudajev, Vladimír - Svoboda, Petr
High Efficacy but Low Potency of delta-Opioid Receptor-G Protein Coupling in Brij-58-Treated, Low-Density Plasma Membrane Fragments.
PLoS ONE. Roč. 10, č. 8 (2015), e0135664. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR(CZ) GAP207/12/0919
Institutional support: RVO:67985823 ; RVO:61388955
Keywords : delta - opioid receptor * G protein coupling * detergent * efficacy * potency
Subject RIV: CE - Biochemistry; CF - Physical ; Theoretical Chemistry (UFCH-W)
Impact factor: 3.057, year: 2015
Permanent Link: http://hdl.handle.net/11104/0249343 - 8.0428162 - FGÚ 2015 RIV CZ eng J - Journal Article
Jakubík, Jan - Šantrůčková, Eva - Randáková, Alena - Janíčková, Helena - Zimčík, Pavel - Rudajev, Vladimír - Michal, Pavel - El-Fakahany, E. E. - Doležal, Vladimír
Outline of therapeutic interventions with muscarinic receptor-mediated transmission.
Physiological Research. Roč. 63, Suppl.1 (2014), S177-S189. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR(CZ) GA305/09/0681; GA ČR(CZ) GAP304/12/0259; GA MŠMT(CZ) 7E10060
Institutional support: RVO:67985823
Keywords : cholinergic transmission * muscarinic receptors * therapy * Alzheimer's disease, * schizophrenia
Subject RIV: ED - Physiology
Impact factor: 1.293, year: 2014
Permanent Link: http://hdl.handle.net/11104/0233580 - 9.0393015 - FGÚ 2014 RIV NL eng J - Journal Article
Janíčková, Helena - Rudajev, Vladimír - Zimčík, Pavel - Jakubík, Jan - Tanila, H. - El-Fakahany, E. E. - Doležal, Vladimír
Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid beta(1-42).
Neuropharmacology. Roč. 67, April (2013), s. 272-283. ISSN 0028-3908. E-ISSN 1873-7064
R&D Projects: GA ČR(CZ) GA305/09/0681; GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) 7E10060
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : Alzheimer´s Disease * muscarinic receptors * G-proteins
Subject RIV: ED - Physiology
Impact factor: 4.819, year: 2013
Permanent Link: http://hdl.handle.net/11104/0221786 - 10.0345059 - FGÚ 2011 RIV US eng J - Journal Article
Machová, Eva - Rudajev, Vladimír - Smyčková, Helena - Koivisto, H. - Tanila, H. - Doležal, Vladimír
Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice.
Neurobiology of Disease. Roč. 38, č. 1 (2010), s. 27-35. ISSN 0969-9961. E-ISSN 1095-953X
R&D Projects: GA AV ČR(CZ) IAA500110703; GA MŠMT(CZ) LC554
Grant - others:EC(XE) 211696
Institutional research plan: CEZ:AV0Z50110509
Keywords : Alzheimer´s disease * acetylcholine release * amyloid
Subject RIV: CE - Biochemistry
Impact factor: 5.121, year: 2010
Permanent Link: http://hdl.handle.net/11104/0186423