Search results
- 1.0585334 - FGÚ 2025 RIV GB eng J - Journal Article
Honzejková, K. - Košek, Dalibor - Obšilová, Veronika - Obšil, Tomáš
The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1.
eLife. Roč. 13, Mar 27 (2024), č. článku RP95199. ISSN 2050-084X. E-ISSN 2050-084X
R&D Projects: GA ČR(CZ) GA19-00121S
Research Infrastructure: CIISB III - 90242
Institutional support: RVO:67985823
Keywords : MAP3K * ASK1 kinase * Thioredoxin * cryo-EM
OECD category: Biochemistry and molecular biology
Impact factor: 7.7, year: 2022
Method of publishing: Open access
https://doi.org/10.7554/eLife.95199.2
Permanent Link: https://hdl.handle.net/11104/0353047 - 2.0583021 - FGÚ 2025 RIV CH eng J - Journal Article
Obšilová, Veronika - Obšil, T.
The yeast 14-3-3 proteins Bmh1 and Bmh2 regulate key signaling pathways.
Frontiers in molecular biosciences. Roč. 11, Jan 24 (2024), č. článku 1327014. E-ISSN 2296-889X
R&D Projects: GA ČR(CZ) GA23-04686S
Institutional support: RVO:67985823
Keywords : 14-3-3 proteins * yeast * protein-protein interaction * phosphorylation * molecular mechanism * scaffolding * adaptor protein
OECD category: Biochemical research methods
Impact factor: 5, year: 2022
Method of publishing: Open access
https://doi.org/10.3389/fmolb.2024.1327014
Permanent Link: https://hdl.handle.net/11104/0351172 - 3.0576929 - FGÚ 2024 RIV US eng J - Journal Article
Petrvalská, Olivia - Honzejková, K. - Koupilová, N. - Herman, P. - Obšilová, Veronika - Obšil, Tomáš
14-3-3 protein inhibits CaMKK1 by blocking the kinase active site with its last two C-terminal helices.
Protein Science. Roč. 32, č. 11 (2023), č. článku e4805. ISSN 0961-8368. E-ISSN 1469-896X
R&D Projects: GA ČR(CZ) GA19-00121S
Research Infrastructure: CIISB II - 90127
Institutional support: RVO:67985823
Keywords : 14-3-3 proteins * calcium/calmodulin-dependent protein kinase * CaMKK * fluorescence spectroscopy * hydrogen/deuterium exchange coupled to MS * protein–protein interaction * SAXS
OECD category: Biochemistry and molecular biology
Impact factor: 8, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/pro.4805
Permanent Link: https://hdl.handle.net/11104/0346310 - 4.0571383 - FGÚ 2024 RIV NL eng J - Journal Article
Masaryk, Jakub - Kale, Deepika - Pohl, Pavel - Ruiz-Castilla, F. J. - Zimmermannová, Olga - Obšilová, Veronika - Ramos, J. - Sychrová, Hana
The second intracellular loop of the yeast Trk1 potassium transporter is involved in regulation of activity, and interaction with 14–3-3 proteins.
Computational and Structural Biotechnology Journal. Roč. 21, April (2023), s. 2705-2716. ISSN 2001-0370. E-ISSN 2001-0370
R&D Projects: GA ČR(CZ) GA20-04420S; GA ČR(CZ) GA21-08985S; GA MŠMT(CZ) LTC20005
Institutional support: RVO:67985823
Keywords : potassium ion uptake * Saccharomyces cerevisiae * phosphorylation * Trk1 * 14–3–3 proteins
OECD category: Microbiology
Impact factor: 6, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.csbj.2023.04.019
Permanent Link: https://hdl.handle.net/11104/0342627 - 5.0562268 - FGÚ 2023 RIV US eng J - Journal Article
Kohoutová, Klára - Dočekal, V. - Ausserlechner, M. J. - Kaiser, N. - Tekel, A. - Mandal, R. - Horváth, M. - Obšilová, Veronika - Veselý, J. - Hagenbuchner, J. - Obšil, Tomáš
Lengthening the Guanidine–Aryl Linker of Phenylpyrimidinylguanidines Increases Their Potency as Inhibitors of FOXO3-Induced Gene Transcription.
ACS Omega. Roč. 7, č. 38 (2022), s. 34632-34646. ISSN 2470-1343. E-ISSN 2470-1343
R&D Projects: GA ČR(CZ) GA21-02080S
Institutional support: RVO:67985823
Keywords : DNA binding * forkhead box O 3 * nuclear magnetic resonance * neuroblastoma * chemoresistance * senescence
OECD category: Biochemistry and molecular biology
Impact factor: 4.1, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acsomega.2c04613
Permanent Link: https://hdl.handle.net/11104/0334626 - 6.0562211 - FGÚ 2023 RIV CH eng J - Journal Article
Obšilová, Veronika - Obšil, T.
Structural insights into the functional roles of 14-3-3 proteins.
Frontiers in molecular biosciences. Roč. 9, Sep 16 (2022), č. článku 1016071. E-ISSN 2296-889X
R&D Projects: GA ČR(CZ) GA21-02080S; GA ČR(CZ) GA19-00121S
Institutional support: RVO:67985823
Keywords : 14-3-3 proteins * protein-protein interactions * phosphorylation * molecular mechanism * scaffolding * adaptor protein
OECD category: Biochemistry and molecular biology
Impact factor: 5, year: 2022
Method of publishing: Open access
https://doi.org/10.3389/fmolb.2022.1016071
Permanent Link: https://hdl.handle.net/11104/0334618 - 7.0556577 - FGÚ 2023 RIV US eng J - Journal Article
Joshi, Rohit - Pohl, Pavel - Strachotová, D. - Herman, P. - Obšil, Tomáš - Obšilová, Veronika
Nedd4-2 binding to 14-3-3 modulates the accessibility of its catalytic site and WW domains.
Biophysical Journal. Roč. 121, č. 7 (2022), s. 1299-1311. ISSN 0006-3495. E-ISSN 1542-0086
R&D Projects: GA ČR(CZ) GA20-00058S
Research Infrastructure: CIISB II - 90127
Institutional support: RVO:67985823
Keywords : Nedd4-2 ubiquitin ligase * 14-3-3 protein * fluorescence spectroscopy * protein structure and function
OECD category: Biochemistry and molecular biology
Impact factor: 3.4, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.bpj.2022.02.025
Permanent Link: http://hdl.handle.net/11104/0330738 - 8.0556576 - FGÚ 2023 RIV US eng J - Journal Article
Mandal, R. - Kohoutová, Klára - Petrvalská, Olivia - Horváth, M. - Srb, Pavel - Veverka, Václav - Obšilová, Veronika - Obšil, Tomáš
FOXO4 interacts with p53 TAD and CRD and inhibits its binding to DNA.
Protein Science. Roč. 31, č. 5 (2022), č. článku e4287. ISSN 0961-8368. E-ISSN 1469-896X
R&D Projects: GA ČR(CZ) GA21-02080S
Research Infrastructure: CIISB II - 90127
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : DNA binding * forkhead box O 4 * nuclear magnetic resonance * protein-protein interaction * senescence * transcription factor p53
OECD category: Biochemistry and molecular biology
Impact factor: 8, year: 2022
Method of publishing: Limited access
https://doi.org/10.1002/pro.4287
Permanent Link: http://hdl.handle.net/11104/0330737 - 9.0551597 - FGÚ 2022 RIV CH eng J - Journal Article
Obšilová, Veronika - Honzejková, K. - Obšil, Tomáš
Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions.
International Journal of Molecular Sciences. Roč. 22, č. 24 (2021), č. článku 13395. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA19-00121S; GA ČR(CZ) GA20-00058S
Institutional support: RVO:67985823
Keywords : ASK1 * phosphorylation * MAP kinase * 14-3-3 * kinase * protein–protein interaction
OECD category: Biochemistry and molecular biology
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1422-0067/22/24/13395
Permanent Link: http://hdl.handle.net/11104/0326849 - 10.0545402 - FGÚ 2022 RIV GB eng J - Journal Article
Horváth, Matej - Petrvalská, Olivia - Herman, P. - Obšilová, Veronika - Obšil, Tomáš
14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites.
Communications Biology. Roč. 4, č. 1 (2021), č. článku 986. E-ISSN 2399-3642
R&D Projects: GA ČR(CZ) GA19-00121S
Research Infrastructure: CIISB II - 90127
Institutional support: RVO:67985823
Keywords : protein structure and function * protein kinase * DAPK * 14-3-3 protein * apoptosis * phosphorylation
OECD category: Biochemistry and molecular biology
Impact factor: 6.548, year: 2021
Method of publishing: Open access
https://doi.org/10.1038/s42003-021-02518-y
Permanent Link: http://hdl.handle.net/11104/0322100