Search results
- 1.0586924 - ÚOCHB 2025 RIV US eng J - Journal Article
Volek, Martin - Kurfürst, Jaroslav - Kožíšek, Milan - Srb, Pavel - Veverka, Václav - Curtis, Edward A.
Apollon: a deoxyribozyme that generates a yellow product.
Nucleic Acids Research. (2024). ISSN 0305-1048. E-ISSN 1362-4962
R&D Projects: GA ČR(CZ) GA24-11210S; GA MŠMT(CZ) EH22_008/0004575
Institutional support: RVO:61388963
Impact factor: 14.9, year: 2022
Method of publishing: Open access
https://doi.org/10.1093/nar/gkae490
Permanent Link: https://hdl.handle.net/11104/0354293File Download Size Commentary Version Access 10.1093nargkae490.pdf 0 2.2 MB Publisher’s postprint open-access - 2.0563164 - ÚOCHB 2023 RIV NL eng J - Journal Article
Radilová, Kateřina - Zima, Václav - Král, Michal - Machara, Aleš - Majer, Pavel - Hodek, Jan - Weber, Jan - Brynda, Jiří - Strmeň, Timotej - Konvalinka, Jan - Kožíšek, Milan
Thermodynamic and structural characterization of an optimized peptide-based inhibitor of the influenza polymerase PA-PB1 subunit interaction.
Antiviral Research. Roč. 208, December (2022), č. článku 105449. ISSN 0166-3542. E-ISSN 1872-9096
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963
Keywords : antiviral peptides * influenza A polymerase * protein-protein interaction * AlphaScreen * isothermal titration calorimetry
OECD category: Biochemistry and molecular biology
Impact factor: 7.6, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.antiviral.2022.105449
Permanent Link: https://hdl.handle.net/11104/0335206File Download Size Commentary Version Access 10.1016j.antiviral.2022.105449.pdf 5 6.4 MB Publisher’s postprint open-access - 3.0544040 - ÚOCHB 2022 RIV CH eng J - Journal Article
Reiberger, Róbert - Radilová, Kateřina - Král, Michal - Zima, Václav - Majer, Pavel - Brynda, Jiří - Dračínský, Martin - Konvalinka, Jan - Kožíšek, Milan - Machara, Aleš
Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors.
International Journal of Molecular Sciences. Roč. 22, č. 14 (2021), č. článku 7735. E-ISSN 1422-0067
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LM2018133
Institutional support: RVO:61388963
Keywords : bio-isosterism * cross-coupling * endonuclease inhibitor * flavonoids * influenza * Mannich reaction * RNA polymerase
OECD category: Biochemistry and molecular biology
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://doi.org/10.3390/ijms22147735
Permanent Link: http://hdl.handle.net/11104/0321100 - 4.0541558 - ÚOCHB 2022 RIV DE eng J - Journal Article
Smola, Miroslav - Gutten, Ondrej - Dejmek, Milan - Kožíšek, Milan - Evangelidis, Thomas - Tehrani, Zahra Aliakbar - Novotná, Barbora - Nencka, Radim - Birkuš, Gabriel - Rulíšek, Lubomír - Bouřa, Evžen
Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein.
Angewandte Chemie - International Edition. Roč. 60, č. 18 (2021), s. 10172-10178. ISSN 1433-7851. E-ISSN 1521-3773
R&D Projects: GA ČR(CZ) GA20-08772S; GA MŠMT(CZ) EF16_019/0000729
Research Infrastructure: e-INFRA CZ - 90140
Institutional support: RVO:61388963
Keywords : conformational analysis * cyclic dinucleotides * entropy * quantum chemistry * strain energy
OECD category: Physical chemistry
Impact factor: 16.823, year: 2021
Method of publishing: Open access
https://doi.org/10.1002/anie.202016805
Permanent Link: http://hdl.handle.net/11104/0319101 - 5.0541489 - ÚOCHB 2022 RIV CH eng J - Journal Article
Gregor, Jiří - Radilová, Kateřina - Brynda, Jiří - Fanfrlík, Jindřich - Konvalinka, Jan - Kožíšek, Milan
Structural and Thermodynamic Analysis of the Resistance Development to Pimodivir (VX-787), the Clinical Inhibitor of Cap Binding to PB2 Subunit of Influenza A Polymerase.
Molecules. Roč. 26, č. 4 (2021), č. článku 1007. E-ISSN 1420-3049
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Research Infrastructure: e-INFRA CZ - 90140
Institutional support: RVO:61388963
Keywords : influenza A polymerase * antivirals * pimodivir * VX-787 * resistance
OECD category: Biochemistry and molecular biology
Impact factor: 4.927, year: 2021
Method of publishing: Open access
https://doi.org/10.3390/molecules26041007
Permanent Link: http://hdl.handle.net/11104/0319054 - 6.0541319 - ÚOCHB 2022 RIV US eng J - Journal Article
Vavřina, Zdeněk - Gutten, Ondrej - Smola, Miroslav - Zavřel, Martin - Tehrani, Zahra Aliakbar - Charvát, Vilém - Kožíšek, Milan - Bouřa, Evžen - Birkuš, Gabriel - Rulíšek, Lubomír
Protein-Ligand Interactions in the STING Binding Site Probed by Rationally Designed Single-Point Mutations: Experiment and Theory.
Biochemistry. Roč. 60, č. 8 (2021), s. 607-620. ISSN 0006-2960
R&D Projects: GA ČR(CZ) GA20-08772S; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : ligand-binding * STING protein * structural biology * QM/MM calculations
OECD category: Biochemistry and molecular biology
Impact factor: 3.321, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.biochem.0c00949
Permanent Link: http://hdl.handle.net/11104/0318895 - 7.0536615 - ÚOCHB 2022 RIV NL eng J - Journal Article
Hejdánek, Jakub - Radilová, Kateřina - Pachl, Petr - Hodek, Jan - Machara, Aleš - Weber, Jan - Řezáčová, Pavlína - Konvalinka, Jan - Kožíšek, Milan
Structural characterization of the interaction between the C-terminal domain of the influenza polymerase PA subunit and an optimized small peptide inhibitor.
Antiviral Research. Roč. 185, Jan (2021), č. článku 104971. ISSN 0166-3542. E-ISSN 1872-9096
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LM2018133
Institutional support: RVO:61388963
Keywords : antiviral peptides * influenza a polymerase * protein-protein interaction * AlphaScreen
OECD category: Biochemistry and molecular biology
Impact factor: 10.103, year: 2021
Method of publishing: Open access
https://doi.org/10.1016/j.antiviral.2020.104971
Permanent Link: http://hdl.handle.net/11104/0316256 - 8.0531977 - ÚOCHB 2021 RIV FR eng J - Journal Article
Zima, Václav - Radilová, Kateřina - Kožíšek, Milan - Berenguer Albiñana, Carlos - Karlukova, Elena - Brynda, Jiří - Fanfrlík, Jindřich - Flieger, Miroslav - Hodek, Jan - Weber, Jan - Majer, Pavel - Konvalinka, Jan - Machara, Aleš
Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors.
European Journal of Medicinal Chemistry. Roč. 208, Dec 15 (2020), č. článku 112754. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) LM2018133; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963 ; RVO:61388971
Keywords : influenza * RNA polymerase * polyphenols * PAN endonuclease inhibitors * RNA polymerase
OECD category: Medicinal chemistry; Microbiology (MBU-M)
Impact factor: 6.514, year: 2020
Method of publishing: Open access
https://doi.org/10.1016/j.ejmech.2020.112754
Permanent Link: http://hdl.handle.net/11104/0310596 - 9.0521013 - ÚOCHB 2021 RIV GB eng J - Journal Article
Began, Jakub - Cordier, B. - Březinová, Jana - Delisle, J. - Hexnerová, Rozálie - Srb, Pavel - Rampírová, Petra - Kožíšek, Milan - Baudet, M. - Couté, Y. - Galinier, A. - Veverka, Václav - Doan, T. - Stříšovský, Kvido
Rhomboid intramembrane protease YqgP licenses bacterial membrane protein quality control as adaptor of FtsH AAA protease.
EMBO Journal. Roč. 39, č. 10 (2020), č. článku e102935. ISSN 0261-4189. E-ISSN 1460-2075
R&D Projects: GA MŠMT LO1302; GA MŠMT(CZ) EF16_019/0000729; GA ČR(CZ) GA18-09556S
Institutional support: RVO:61388963
Keywords : ER-associated degradation * intramembrane protease * membrane transporter * proteostasis * rhomboid
OECD category: Biochemistry and molecular biology
Impact factor: 11.598, year: 2020
Method of publishing: Open access
https://www.embopress.org/doi/full/10.15252/embj.2019102935
Permanent Link: http://hdl.handle.net/11104/0305666 - 10.0505749 - ÚOCHB 2020 RIV GB eng J - Journal Article
Zima, Václav - Berenguer Albiñana, Carlos - Rojíková, Kateřina - Pokorná, Jana - Pachl, Petr - Řezáčová, Pavlína - Hudlický, Jason - Navrátil, Václav - Majer, Pavel - Konvalinka, Jan - Kožíšek, Milan - Machara, Aleš
Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1.
Bioorganic & Medicinal Chemistry. Roč. 27, č. 13 (2019), s. 2935-2947. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : influenza neuraminidase * oseltamivir * click chemistry * crystal structure
OECD category: Biochemistry and molecular biology
Impact factor: 3.073, year: 2019
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0968089619305358?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0297147