Search results
- 1.0571975 - ÚEB 2024 RIV NL eng J - Journal Article
Kovalová, M. - Havlíček, Libor - Djukic, Stefan - Škerlová, Jana - Peřina, M. - Pospíšil, T. - Řezníčková, E. - Řezáčová, Pavlína - Jorda, R. - Kryštof, V.
Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7.
Biomedicine & Pharmacotherapy. Roč. 161, MAY (2023), č. článku 114492. ISSN 0753-3322. E-ISSN 1950-6007
R&D Projects: GA MŠMT LX22NPO5102
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : Cyclin-dependent kinase 7 * Inhibitor * pyrazolo[4,3-d]pyrimidine * Selectivity
OECD category: Medicinal chemistry
Impact factor: 7.5, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.biopha.2023.114492
Permanent Link: https://hdl.handle.net/11104/0342824File Download Size Commentary Version Access 2023_Kovalova_BIOMEDICINE & PHARMACOTHERAPY_114492.pdf 2 3.3 MB Other open-access - 2.0566367 - MBÚ 2023 RIV CH eng J - Journal Article
Kolaříková, Viola - Brodsky, Katerina - Petrásková, Lucie - Pelantová, Helena - Cvačka, Josef - Havlíček, Libor - Křen, Vladimír - Valentová, Kateřina
Sulfation of Phenolic Acids: Chemoenzymatic vs. Chemical Synthesis.
International Journal of Molecular Sciences. Roč. 23, č. 23 (2022), č. článku 15171. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA19-00043S; GA MZd(CZ) NU21-02-00135
Institutional support: RVO:61388971 ; RVO:61388963 ; RVO:61389030
Keywords : sulfation * phenolic acids * aryl sulfotransferase * flavonoid metabolites * biotransformation
OECD category: Organic chemistry; Analytical chemistry (UOCHB-X); Organic chemistry (UEB-Q)
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://www.mdpi.com/1422-0067/23/23/15171
Permanent Link: https://hdl.handle.net/11104/0337718 - 3.0562052 - ÚEB 2023 RIV US eng J - Journal Article
Jorda, R. - Havlíček, Libor - Peřina, M. - Vojáčková, V. - Pospíšil, T. - Djukic, Stefan - Škerlová, Jana - Grúz, J. - Renešová, N. - Klener, P. - Řezáčová, Pavlína - Strnad, Miroslav - Kryštof, V.
3,5,7-Substituted Pyrazolo[4,3- d]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders.
Journal of Medicinal Chemistry. Roč. 65, č. 13 (2022), s. 8881-8896. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA ČR(CZ) GA20-25308S
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : Antineoplastic Agents * Cell Line * Cyclin-Dependent Kinases
OECD category: Organic chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c02184
Permanent Link: https://hdl.handle.net/11104/0334472File Download Size Commentary Version Access 2022_Jorda_JOURNAL OF MEDICINAL CHEMISTRY_8881.pdf 3 9 MB Other require - 4.0545890 - ÚEB 2022 RIV GB eng J - Journal Article
Maková, B. - Mik, V. - Lišková, B. - Gonzalez, G. - Vítek, D. - Medvedíková, M. - Monfort, B. - Ručilová, V. - Kadlecová, A. - Khirsariya, P. - Gándara Barreiro, Z. - Havlíček, Libor - Zatloukal, M. - Soural, M. - Paruch, K. - D'Autréaux, B. - Hajdúch, M. - Strnad, M. - Voller, Jiří
Cytoprotective activities of kinetin purine isosteres.
Bioorganic & Medicinal Chemistry. Roč. 33, MAR 1 (2021), č. článku 115993. ISSN 0968-0896. E-ISSN 1464-3391
Institutional support: RVO:61389030
Keywords : bioisostery – Friedreich́s ataxia * Cytokinin * Kinetin * Mitoprotection – familial dysautonomia * Neuroprotection
OECD category: Pharmacology and pharmacy
Impact factor: 3.461, year: 2021
Method of publishing: Open access
http://doi.org/10.1016/j.bmc.2021.115993
Permanent Link: http://hdl.handle.net/11104/0322516File Download Size Commentary Version Access 2021_Makova_BIOORGANIC & MEDICINAL CHEMISTRY_115993.pdf 1 1.1 MB Other open-access - 5.0545687 - ÚEB 2022 RIV GB eng J - Journal Article
Nisler, Jaroslav - Kopečný, D. - Pěkná, Z. - Končitíková, R. - Koprna, R. - Murvanidze, N. - Werbrouck, S. - Havlíček, Libor - De Diego, N. - Kopečná, M. - Wimmer, Zdeněk - Briozzo, P. - Moréra, S. - Zalabák, D. - Spíchal, L. - Strnad, Miroslav
Diphenylurea-derived cytokinin oxidase/dehydrogenase inhibitors for biotechnology and agriculture.
Journal of Experimental Botany. Roč. 72, č. 2 (2021), s. 355-370. ISSN 0022-0957. E-ISSN 1460-2431
R&D Projects: GA ČR(CZ) GA18-07563S; GA MŠMT(CZ) EF16_019/0000827
Institutional support: RVO:61389030
Keywords : Agriculture * biotechnology * CKX inhibitor * crystal structure * cytokinin * cytokinin oxidase/dehydrogenase * diphenylurea * plant tissue culture * stress * yield
OECD category: Biochemistry and molecular biology
Impact factor: 7.378, year: 2021
Method of publishing: Open access
http://doi.org/10.1093/jxb/eraa437
Permanent Link: http://hdl.handle.net/11104/0322360File Download Size Commentary Version Access 2021_Nisler_Journal of Experimental Botany_355.pdf 3 3.2 MB Other open-access - 6.0505109 - ÚEB 2020 RIV US eng J - Journal Article
Jorda, Radek - Havlíček, Libor - Šturc, Antonín - Tušková, D. - Daumová, L. - Alam, M. - Škerlová, Jana - Nekardová, Michaela - Peřina, Miroslav - Pospíšil, Tomáš - Široká, Jitka - Urbánek, Lubor - Pachl, Petr - Řezáčová, Pavlína - Strnad, Miroslav - Klener, P. - Kryštof, Vladimír
3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.
Journal of Medicinal Chemistry. Roč. 62, č. 9 (2019), s. 4606-4623. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GA17-14007S; GA ČR(CZ) GBP208/12/G016
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : BIOLOGICAL EVALUATION * CELL-CYCLE * ROSCOVITINE
OECD category: Hematology; Medicinal chemistry (UOCHB-X)
Impact factor: 6.205, year: 2019
Method of publishing: Limited access
http://doi.org/10.1021/acs.jmedchem.9b00189
Permanent Link: http://hdl.handle.net/11104/0296627File Download Size Commentary Version Access 2019_Jorda_JOURNAL OF MEDICINAL CHEMISTRY_4606.pdf 4 4.5 MB Other require - 7.0498271 - ÚEB 2019 RIV GB eng J - Journal Article
Buček, J. - Zatloukal, M. - Havlíček, Libor - Plíhalová, Lucie - Pospíšil, T. - Novák, Ondřej - Doležal, Karel - Strnad, Miroslav
Total synthesis of [N-15]-labelled C6-substituted purines from [N-15]-formamide-easy preparation of isotopically labelled cytokinins and derivatives.
Royal Society Open Science. Roč. 5, č. 11 (2018), č. článku 181322. ISSN 2054-5703. E-ISSN 2054-5703
R&D Projects: GA ČR(CZ) GA16-04184S; GA MŠMT(CZ) LO1204; GA MŠMT(CZ) EF16_019/0000738
Institutional support: RVO:61389030
Keywords : cell-division * biological-activity * aromatic cytokinins * plant-tissues * adenine * zeatin * identification * diphosphate * mechanism * thaliana * synthesis * N-15-labelled * purine * cytokinin
OECD category: Biochemical research methods
Impact factor: 2.515, year: 2018
Permanent Link: http://hdl.handle.net/11104/0290663File Download Size Commentary Version Access 2018_Bucek_ROYAL SOCIETY OPEN SCIENCE_181322.pdf 2 993.3 KB Other open-access - 8.0485771 - ÚEB 2018 RIV US eng J - Journal Article
Özdemir, Zülal - Bildziukevich, Uladzimir - Šaman, David - Havlíček, Libor - Rárová, L. - Navrátilová, L. - Wimmer, Zdeněk
Amphiphilic derivatives of (3β,17β)-3-hydroxyandrost-5-ene-17-carboxylic acid.
Steroids. Roč. 128, DEC (2017), s. 58-67. ISSN 0039-128X. E-ISSN 1878-5867
R&D Projects: GA MŠMT LD15012
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : Amphiphile * Antimicrobial activity * Cytotoxicity * Diamine * Polyamine * Steroid
OECD category: Organic chemistry
Impact factor: 2.523, year: 2017
Permanent Link: http://hdl.handle.net/11104/0280714File Download Size Commentary Version Access 2017_Ozdemir_Steroids_58.pdf 0 253.2 KB Other open-access - 9.0463991 - ÚEB 2017 RIV GB eng J - Journal Article
Zhang, S. - Ulrich, M. - Gromnicka, A. - Havlíček, Libor - Kryštof, Vladimír - Jorda, Radek - Strnad, Miroslav - Vollmar, A. M. - Zahler, S.
Anti-angiogenic effects of novel cyclin-dependent kinase inhibitors with a pyrazolo[4,3-d]pyrimidine scaffold.
British Journal of Pharmacology. Roč. 173, č. 17 (2016), s. 2645-2656. ISSN 0007-1188. E-ISSN 1476-5381
R&D Projects: GA ČR GA14-19590S
Institutional support: RVO:61389030
Keywords : CELL-CYCLE * PURINE ANALOGS * CONCISE GUIDE
Subject RIV: FD - Oncology ; Hematology
Impact factor: 5.491, year: 2016
Permanent Link: http://hdl.handle.net/11104/0263079File Download Size Commentary Version Access 2016_Zhang_BRITISH JOURNAL OF PHARMACOLOGY_2645.pdf 0 1.5 MB Other open-access - 10.0459351 - ÚEB 2017 RIV FR eng J - Journal Article
Vymětalová, Ladislava - Havlíček, Libor - Šturc, Antonín - Skrášková, Zuzana - Jorda, Radek - Pospíšil, Tomáš - Strnad, Miroslav - Kryštof, Vladimír
5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases.
European Journal of Medicinal Chemistry. Roč. 110, MAR 3 (2016), s. 291-301. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) LO1204; GA ČR(CZ) GA15-15264S
Institutional support: RVO:61389030
Keywords : Cyclin-dependent kinase * Inhibitor * Selectivity
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.519, year: 2016
Permanent Link: http://hdl.handle.net/11104/0259567File Download Size Commentary Version Access 2016_Vymetalova_EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY_291.pdf 0 1.2 MB Other open-access